Chiral π\pi-exchange NN-potentials: Results for diagrams proportional to g_A^4 and g_A^6

We calculate in (two-loop) chiral perturbation theory the local NN-potentials generated by the three-pion exchange diagrams proportional to g_A^4 and g_A^6. Surprisingly, we find that the total isoscalar central $3\pi$-exchange potential vanishes identically. The individually largest $3\pi$-exchange potentials are of isoscalar spin-spin, isovector central and isoscalar tensor type. For these potentials simple analytical expressions can be given. The strength of these dominant $3\pi$-exchange potentials at r=1.0 fm is 4.6 MeV, 2.9 MeV and 1.4 MeV, respectively. Furthermore, we observe that the spin-spin and tensor potentials due to the diagrams proportional to g_A^6 do not exist in the infinite nucleon mass limit.Comment: 8 pages, 5 figure

Substance P regulates puberty onset and fertility in the female mouse

Puberty is a tightly regulated process that leads to reproductive capacity. Kiss1 neurons are crucial in this process by stimulating GnRH, yet how Kiss1 neurons are regulated remains unknown. Substance P (SP), an important neuropeptide in pain perception, induces gonadotropin release in adult mice in a kisspeptin-dependent manner. Here, we assessed whether SP, through binding to its receptor NK1R (neurokinin 1 receptor), participates in the timing of puberty onset and fertility in the mouse. We observed that 1) selective NK1R agonists induce gonadotropin release in prepubertal females; 2) the expression of Tac1 (encoding SP) and Tacr1 (NK1R) in the arcuate nucleus is maximal before puberty, suggesting increased SP tone; 3) repeated exposure to NK1R agonists prepubertally advances puberty onset; and 4) female Tac1-/- mice display delayed puberty; moreover, 5) SP deficiency leads to subfertility in females, showing fewer corpora lutea and antral follicles and leading to decreased litter size. Thus, our findings support a role for SP in the stimulation of gonadotropins before puberty, acting via Kiss1 neurons to stimulate GnRH release, and its involvement in the attainment of full reproductive capabilities in female mice. Copyright © 2015 by the Endocrine Society

An adaptive wavelet-based collocation method for solving multiscale problems in continuum mechanics

Computational multiscale methods are highly sophisticated numerical approaches to predict the constitutive response of heterogeneous materials from their underlying microstructures. However, the quality of the prediction intrinsically relies on an accurate representation of the microscale morphology and its individual constituents, which makes these formulations computationally demanding. Against this background, the applicability of an adaptive wavelet-based collocation approach is studied in this contribution. It is shown that the Hill–Mandel energy equivalence condition can naturally be accounted for in the wavelet basis, (discrete) wavelet-based scale-bridging relations are derived, and a wavelet-based mapping algorithm for internal variables is proposed. The characteristic properties of the formulation are then discussed by an in-depth analysis of elementary one-dimensional problems in multiscale mechanics. In particular, the microscale fields and their macroscopic analogues are studied for microstructures that feature material interfaces and material interphases. Analytical solutions are provided to assess the accuracy of the simulation results.</p

An adaptive wavelet-based collocation method for solving multiscale problems in continuum mechanics

Computational multiscale methods are highly sophisticated numerical approaches to predict the constitutive response of heterogeneous materials from their underlying microstructures. However, the quality of the prediction intrinsically relies on an accurate representation of the microscale morphology and its individual constituents, which makes these formulations computationally demanding. Against this background, the applicability of an adaptive wavelet-based collocation approach is studied in this contribution. It is shown that the Hill–Mandel energy equivalence condition can naturally be accounted for in the wavelet basis, (discrete) wavelet-based scale-bridging relations are derived, and a wavelet-based mapping algorithm for internal variables is proposed. The characteristic properties of the formulation are then discussed by an in-depth analysis of elementary one-dimensional problems in multiscale mechanics. In particular, the microscale fields and their macroscopic analogues are studied for microstructures that feature material interfaces and material interphases. Analytical solutions are provided to assess the accuracy of the simulation results.</p

Chiral Unitary Approach To The N*N*pi, N*N*eta Couplings For The N*(1535) Resonance

Using a chiral unitary model in which the negative parity nucleon resonance $N^\ast \equiv N^\ast(1535)$ is generated dynamically by means of the Bethe Salpeter equation with coupled meson baryon channels in the $S = 0$ sector, we have obtained the $\pi^0 N^\ast N^\ast$ and $\eta N^\ast N^\ast$ couplings. The $\pi^0 N^\ast N^\ast$ coupling has smaller strength and the same sign as the $\pi^0 N N$ coupling. This rules out the mirror assignment of chiral symmetry where the ground state nucleon $N$ and the negative parity resonance $N^\ast$ are envisaged as chiral partners in the baryon sector.Comment: 30 pages, 15 figures (ps files). The new version discusses pi-N scattering around the N*(1535) resonanc

Primordial black hole production due to preheating

During the preheating process at the end of inflation the amplification of field fluctuations can lead to the amplification of curvature perturbations. If the curvature perturbations on small scales are sufficiently large, primordial black holes (PBHs) will be overproduced. In this paper we study PBH production in the two-field preheating model with quadratic inflaton potential. We show that for many values of the inflaton mass m, and coupling g, small scale perturbations will be amplified sufficiently, before backreaction can shut off preheating, so that PBHs will be overproduced during the subsequent radiation dominated era.Comment: 5 pages, 3 eps figures. Minor changes to match version to appear in PRD as a rapid communicatio

The clinical and biological impact of new pathogen inactivation technologies on platelet concentrates.

Since 1990, several techniques have been developed to photochemically inactivate pathogens in platelet concentrates, potentially leading to safer transfusion therapy. The three most common methods are amotosalen/UVA (INTERCEPT Blood System), riboflavin/UVA-UVB (MIRASOL PRT), and UVC (Theraflex-UV). We review the biology of pathogen inactivation methods, present their efficacy in reducing pathogens, discuss their impact on the functional aspects of treated platelets, and review clinical studies showing the clinical efficiency of the pathogen inactivation methods and their possible toxicity

Photoproduction of the Lambda(1405) on the proton and nuclei

We study the gamma p ---> K^+ Lambda(1405) reaction at energies close to threshold using a chiral unitary model where the resonance is generated dynamically from K^-p interaction with other channels constructed from the octets of baryons and mesons. Predictions are made for cross sections into several channels and it is shown that the detection of the K^+ is sufficient to determine the shape and strength of the Lambda(1405) resonance. The determination of the resonance properties in nuclei requires instead the detection of the resonance decay channels. Pauli blocking effects on the resonance, which have been shown to be very important for the resonance at rest in the nucleus, are irrelevant here where the resonance is produced with a large momentum. The nuclear modifications here would thus offer information on the resonance and K^- nucleus dynamics complementary to the one offered so far by K^- atoms.Comment: 9 pages, 4 postscripts figure

Chiral dynamics of p-wave in K^- p and coupled states

We perform an evaluation of the p-wave amplitudes of meson-baryon scattering in the strangeness S=-1 sector starting from the lowest order chiral Lagrangians and introducing explicitly the Sigma^* field with couplings to the meson-baryon states obtained using SU(6) symmetry. The N/D method of unitarization is used, equivalent, in practice, to the use of the Bethe-Salpeter equation with a cut-off. The procedure leaves no freedom for the p-waves once the s-waves are fixed and thus one obtains genuine predictions for the p-wave scattering amplitudes, which are in good agreement with experimental results for differential cross sections, as well as for the width and partial decay widths of the Sigma^*(1385).Comment: LaTeX, 18 pages, 6 figure

Diversifying selection and color-biased dispersal in the asp viper.

BACKGROUND: The presence of intraspecific color polymorphism can have multiple impacts on the ecology of a species; as a consequence, particular color morphs may be strongly selected for in a given habitat type. For example, the asp viper (Vipera aspis) shows a high level of color polymorphism. A blotched morph (cryptic) is common throughout its range (central and western Europe), while a melanistic morph is frequently found in montane populations, presumably for thermoregulatory reasons. Besides, rare atypical uniformly colored individuals are known here and there. Nevertheless, we found in a restricted treeless area of the French Alps, a population containing a high proportion (&gt;50%) of such specimens. The aim of the study is to bring insight into the presence and function of this color morph by (i) studying the genetic structure of these populations using nine microsatellite markers, and testing for (ii) a potential local diversifying selection and (iii) differences in dispersal capacity between blotched and non-blotched vipers. RESULTS: Our genetic analyses support the occurrence of local diversifying selection for the non-blotched phenotype. In addition, we found significant color-biased dispersal, blotched individuals dispersing more than atypical individuals. CONCLUSION: We hypothesize that, in this population, the non-blotched phenotype possess an advantage over the typical one, a phenomenon possibly due to a better background matching ability in a more open habitat. In addition, color-biased dispersal might be partly associated with the observed local diversifying selection, as it can affect the genetic structure of populations, and hence the distribution of color morphs