380 research outputs found
Rietveld refinement of KLaTiO4 from X-ray powder data
Potassium lanthanum titanate(IV), KLaTiO4, has been synthesized by conventional solid-state reaction. It crystallizes isotypically with the NaLnTiO4 (Ln = La, Pr, Nd, Sm, Eu, Gd, Y and Lu) family. Five of the six atoms in the asymmetric unit (one K, one La, one Ti and two O atoms) are situated on sites with 4mm symmetry, whereas one O atom has 2mm. site symmetry. The crystal structure can be described as being composed of single layers of distorted corner-sharing TiO6 octaÂhedra extending parallel to (001). The layers are alternately separated by K+ and La3+ cations along [001]. The coordination number of both K+ and La3+ cations is nine, resulting in distorted KO9 and LaO9 polyhedra
Li2Ca1.5Nb3O10 from X-ray powder data
Lithium calcium niobium oxide (2/1.5/3/10), Li2Ca1.5Nb3O10, has been synthesized by conventional solid-state reaction. Its structure consists of triple-layer perovskite slabs of corner-sharing NbO6 octaÂhedra interÂleaved with lithium ions; Ca cations partially occupy the perovskite A sites at 75% occupancy probability. All eight atoms in the asymmetric unit are on special positions: one Nb atom has site symmetry 4/mmm; the second Nb, both K, the Sr and two O atoms have site symmetry 4mm; the remaining two O atoms have site symmetries 2mm. and mmm., respectively
Autonomous Vehicle Battery State-of-Charge Prognostics Enhanced Mission Planning
Most mission planning algorithms are designed for healthy systems. When faults occur in a system, it is advantageous to optimize the mission plan by taking the system health condition into consideration. In this paper, a mission planning scheme is proposed to integrate real-time prognostics in a receding horizon path planning framework to accommodate the system fault. In this scheme, the state-of-charge of a battery is monitored and predicted by a particle-filtering based prognostic algorithm. The predicted state-of-charge and remaining useful life of the battery are used in the mission planning to minimize mission failure risk. A series of experiments are presented on a robotic platform, which is powered by a Lithium-ion battery, to demonstrate and verify the proposed scheme
RbCa2Nb3O10 from X-ray powder data
Rubidium dicalcium triniobate(V), RbCa2Nb3O10, has been synthesized by solid-state reaction and its crystal structure refined from X-ray powder diffraction data using Rietveld analysis. The compound is a three-layer perovskite Dion–Jacobson phase with the perovskite-like slabs derived by termination of the three-dimensional CaNbO3 perovskite structure along the ab plane. The rubidium ions (4/mmm symmetry) are located in the interÂstitial space
Plasmoid ejection and secondary current sheet generation from magnetic reconnection in laser-plasma interaction
Reconnection of the self-generated magnetic fields in laser-plasma
interaction was first investigated experimentally by Nilson {\it et al.} [Phys.
Rev. Lett. 97, 255001 (2006)] by shining two laser pulses a distance apart on a
solid target layer. An elongated current sheet (CS) was observed in the plasma
between the two laser spots. In order to more closely model magnetotail
reconnection, here two side-by-side thin target layers, instead of a single
one, are used. It is found that at one end of the elongated CS a fan-like
electron outflow region including three well-collimated electron jets appears.
The ( MeV) tail of the jet energy distribution exhibits a power-law
scaling. The enhanced electron acceleration is attributed to the intense
inductive electric field in the narrow electron dominated reconnection region,
as well as additional acceleration as they are trapped inside the rapidly
moving plasmoid formed in and ejected from the CS. The ejection also induces a
secondary CS
Anapole mediated giant photothermal nonlinearity in nanostructured silicon
Featured with a plethora of electric and magnetic Mie resonances, high index
dielectric nanostructures offer a versatile platform to concentrate
light-matter interactions at the nanoscale. By integrating unique features of
far-field scattering control and near-field concentration from radiationless
anapole states, here, we demonstrate a giant photothermal nonlinearity in
single subwavelength-sized silicon nanodisks. The nanoscale energy
concentration and consequent near-field enhancements mediated by the anapole
mode yield a reversible nonlinear scattering with a large modulation depth and
a broad dynamic range, unveiling a record-high nonlinear index change up to 0.5
at mild incident light intensities on the order of MW/cm2. The observed
photothermal nonlinearity showcases three orders of magnitude enhancement
compared with that of unstructured bulk silicon, as well as nearly one order of
magnitude higher than that through the radiative electric dipolar mode. Such
nonlinear scattering can empower distinctive point spread functions in confocal
reflectance imaging, offering the potential for far-field localization of
nanostructured Si with an accuracy approaching 40 nm. Our findings shed new
light on active silicon photonics based on optical anapoles
Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer
AbstractStatins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) inhibitors decreasing serum cholesterol and have shown promise in cancer prevention. In this study, we demonstrated the oncogenic role of HMGR in colorectal cancer (CRC) by disclosing increased HMGR activity in CRC patients and its enhancement of anti-apoptosis and stemness. Our previous studies showed that statins containing carboxylic acid chains possessed activity against histone deacetylases (HDACs), and strengthened their anti-HDAC activity through designing HMGR-HDAC dual inhibitors, JMF compounds. These compounds exerted anti-cancer effect in CRC cells as well as in AOM-DSS and ApcMin/+ CRC mouse models. JMF mostly regulated the genes related to apoptosis and inflammation through genome-wide ChIP-on-chip analysis, and Ingenuity Pathways Analysis (IPA) predicted their respective regulation by NR3C1 and NF-κB. Furthermore, JMF inhibited metastasis, angiogenesis and cancer stemness, and potentiated the effect of oxaliplatin in CRC mouse models. Dual HMGR-HDAC inhibitor could be a potential treatment for CRC
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