Improved fatigue strength of additively manufactured Ti6Al4V by surface post processing

A major challenge for additively manufactured structural parts is the low fatigue strength connected to rough as-built surfaces. In this study, Ti6Al4V manufactured with laser powder bed fusion (L-PBF) and electron beam powder bed fusion (E-PBF) have been subjected to five surface processing methods, shot peening, laser shock peening, centrifugal finishing, laser polishing and linishing, in order to increase the fatigue strength. Shot peened and centrifugal finished L-PBF material achieved comparable fatigue strength to machined material. Moreover, the surface roughness alone was found to be an insufficient indicator on the fatigue strength since subsurface defects were hidden below smooth surfaces.Funding Agencies|Clean Sky 2 joint undertaking under the European Union [738002]; Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research</p

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Genome-wide characterization of the in vivo cellular response to perturbation is fundamental to understanding how cells survive stress. Identifying the proteins and pathways perturbed by small molecules affects biology and medicine by revealing the mechanisms of drug action. We used a yeast chemogenomics platform that quantifies the requirement for each gene for resistance to a compound in vivo to profile 3250 small molecules in a systematic and unbiased manner. We identified 317 compounds that specifically perturb the function of 121 genes and characterized the mechanism of specific compounds. Global analysis revealed that the cellular response to small molecules is limited and described by a network of 45 major chemogenomic signatures. Our results provide a resource for the discovery of functional interactions among genes, chemicals, and biological processes