1,759 research outputs found
Core pinning by intragranular nanoprecipitates in polycrystalline MgCNi_3
The nanostructure and magnetic properties of polycrystalline MgCNi_3 were
studied by x-ray diffraction, electron microscopy, and vibrating sample
magnetometry. While the bulk flux-pinning force curve F_p(H) indicates the
expected grain-boundary pinning mechanism just below T_c = 7.2 K, a systematic
change to pinning by a nanometer-scale distribution of core pinning sites is
indicated by a shift of F_p(H) with decreasing temperature. The lack of scaling
of F_p(H) suggests the presence of 10 to 20% of nonsuperconducting regions
inside the grains, which are smaller than the diameter of fluxon cores 2xi at
high temperature and become effective with decreasing temperature when xi(T)
approaches the nanostructural scale. Transmission electron microscopy revealed
cubic and graphite nanoprecipitates with 2 to 5 nm size, consistent with the
above hypothesis since xi(0) = 6 nm. High critical current densities, more than
10^6 A/cm^2 at 1 T and 4.2 K, were obtained for grain colonies separated by
carbon. Dirty-limit behavior seen in previous studies may be tied to electron
scattering by the precipitates, indicating the possibility that strong core
pinning might be combined with a technologically useful upper critical field if
versions of MgCNi_3 with higher T_c can be found.Comment: 5 pages, 6 figures, submitted to PR
A Novel Approach for Ellipsoidal Outer-Approximation of the Intersection Region of Ellipses in the Plane
In this paper, a novel technique for tight outer-approximation of the
intersection region of a finite number of ellipses in 2-dimensional (2D) space
is proposed. First, the vertices of a tight polygon that contains the convex
intersection of the ellipses are found in an efficient manner. To do so, the
intersection points of the ellipses that fall on the boundary of the
intersection region are determined, and a set of points is generated on the
elliptic arcs connecting every two neighbouring intersection points. By finding
the tangent lines to the ellipses at the extended set of points, a set of
half-planes is obtained, whose intersection forms a polygon. To find the
polygon more efficiently, the points are given an order and the intersection of
the half-planes corresponding to every two neighbouring points is calculated.
If the polygon is convex and bounded, these calculated points together with the
initially obtained intersection points will form its vertices. If the polygon
is non-convex or unbounded, we can detect this situation and then generate
additional discrete points only on the elliptical arc segment causing the
issue, and restart the algorithm to obtain a bounded and convex polygon.
Finally, the smallest area ellipse that contains the vertices of the polygon is
obtained by solving a convex optimization problem. Through numerical
experiments, it is illustrated that the proposed technique returns a tighter
outer-approximation of the intersection of multiple ellipses, compared to
conventional techniques, with only slightly higher computational cost
Brief of Corporate Law Professors as Amici Curie in Support of Respondents
The Supreme Court has looked to the rights of corporate shareholders in determining the rights of union members and non-members to control political spending, and vice versa. The Court sometimes assumes that if shareholders disapprove of corporate political expression, they can easily sell their shares or exercise control over corporate spending. This assumption is mistaken. Because of how capital is saved and invested, most individual shareholders cannot obtain full information about corporate political activities, even after the fact, nor can they prevent their savings from being used to speak in ways with which they disagree. Individual shareholders have no “opt out” rights or practical ability to avoid subsidizing corporate political expression with which they disagree. Nor do individuals have the practical option to refrain from putting their savings into equity investments, as doing so would impose damaging economic penalties and ignore conventional financial guidance for individual investors
The effect of tumour necrosis factor-α (TNF-α) muteins on human neutrophils in vitro
Tumour necrosis factor-α (TNF-α) has been implicated as an important inflammatory mediator. In vitro, TNF-α is reported to activate human polymorphonuclear neutrophils (PMN), inducing responses such as phagocytic activity, degranulation and oxidative metabolism. Biological responses to TNF-α are initiated by its binding to specific cell surface receptors, and various studies have shown that the major TNF receptor species on PMN is the 75 kDa receptor. To verify the suggestion that the receptor binding domain includes the region close to the N-terminus of the TNF-α molecule, four TNF-α derivatives termed muteins were constructed, using a synthetic cDNA fragment substituting the N-terminal 3–7 selected hydrophilic or hydrophobic amino acids in the original TNF-α genomic DNA. Binding of muteins to PMN was assessed using monoclonal antibodies recognizing either the 55 kDa (p55) or the 75 kDa (p75) TNF receptor subtypes. Blocking by muteins of anti-p75 antibody binding to PMN was as expected from their N-terminal amino acid composition and hydrophilic properties. Hydrophilic muteins competed well with anti-TNF receptor antibodies for binding to the p75 receptor. In contrast, hydrophobic muteins were unable to block anti-p75 binding. Similarly, degranulation, chemiluminescence or enhancement of the PMN response to specific stimuli by the muteins correlated with the hydrophilic properties of the muteins. The significance of these observations in relation to the molecular structure of TNF-α is discussed
Future aspects of renal transplantation
New and exciting advances in renal transplantation are continuously being made, and the horizons for organ transplantation are bright and open. This article reviews only a few of the newer advances that will allow renal transplantation to become even more widespread and successful. The important and exciting implications for extrarenal organ transplantation are immediately evident. © 1988 Springer-Verlag
On the construction of high-order force gradient algorithms for integration of motion in classical and quantum systems
A consequent approach is proposed to construct symplectic force-gradient
algorithms of arbitrarily high orders in the time step for precise integration
of motion in classical and quantum mechanics simulations. Within this approach
the basic algorithms are first derived up to the eighth order by direct
decompositions of exponential propagators and further collected using an
advanced composition scheme to obtain the algorithms of higher orders. Contrary
to the scheme by Chin and Kidwell [Phys. Rev. E 62, 8746 (2000)], where
high-order algorithms are introduced by standard iterations of a force-gradient
integrator of order four, the present method allows to reduce the total number
of expensive force and its gradient evaluations to a minimum. At the same time,
the precision of the integration increases significantly, especially with
increasing the order of the generated schemes. The algorithms are tested in
molecular dynamics and celestial mechanics simulations. It is shown, in
particular, that the efficiency of the new fourth-order-based algorithms is
better approximately in factors 5 to 1000 for orders 4 to 12, respectively. The
results corresponding to sixth- and eighth-order-based composition schemes are
also presented up to the sixteenth order. For orders 14 and 16, such highly
precise schemes, at considerably smaller computational costs, allow to reduce
unphysical deviations in the total energy up in 100 000 times with respect to
those of the standard fourth-order-based iteration approach.Comment: 23 pages, 2 figures; submitted to Phys. Rev.
Clinical applications of magnetic resonance imaging based functional and structural connectivity
Advances in computational neuroimaging techniques have expanded the armamentarium of imaging tools available for clinical applications in clinical neuroscience. Non-invasive, in vivo brain MRI structural and functional network mapping has been used to identify therapeutic targets, define eloquent brain regions to preserve, and gain insight into pathological processes and treatments as well as prognostic biomarkers. These tools have the real potential to inform patient-specific treatment strategies. Nevertheless, a realistic appraisal of clinical utility is needed that balances the growing excitement and interest in the field with important limitations associated with these techniques. Quality of the raw data, minutiae of the processing methodology, and the statistical models applied can all impact on the results and their interpretation. A lack of standardization in data acquisition and processing has also resulted in issues with reproducibility. This limitation has had a direct impact on the reliability of these tools and ultimately, confidence in their clinical use. Advances in MRI technology and computational power as well as automation and standardization of processing methods, including machine learning approaches, may help address some of these issues and make these tools more reliable in clinical use. In this review, we will highlight the current clinical uses of MRI connectomics in the diagnosis and treatment of neurological disorders; balancing emerging applications and technologies with limitations of connectivity analytic approaches to present an encompassing and appropriate perspective
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