Hubungan Indeks Massa Tubuh Ibu Dan Peningkatan Berat Badan Saat Kehamilan Dengan Preeklampsia

: Preeclampsia is a health problem that occurs when a pregnancy reaches 20 weeks or more, preeclampsia is accompanied by hypertension and protenuria as main signs. Women with obesity before pregnancy are known to have higher risk to get preeclampsia during pregnancy than those with normal IMT. Excessive weight gain during pregnancy can also increase the risk of preeclampsia in pregnant woman. The purpose of this research is to examine the relationship between maternal body mass index and weight gain during pregnancy with preeclampsia.This research used observasional-analytic method through case-control approach. The number of case group is 38 people and the number of control group is 38 people. The result shows that at risk women were four times more likely to develop preeclampsia during pregnancy than those with normal IMT (OR= 4,32 95% CI= 1,15-16,12), and obese women were five times more likely to develop preeclampsia during pregnancy than those with normal IMT (OR= 5,06 95% CI= 1,46-12,67). The result also shows that women with excessive weight gain during pregnancy were almost three times more likely to develop preeclampsia during preeclampsia than women with normal weight gain during pregnancy (OR=2,53 95% IK= 0,99-31,81). The results show that there is a significant association between maternal IMT and weight gain during pregnancy with preeclampsia

Adiponection Serum Levels in Severe Preeclampsia: Kadar Adiponektin pada Pasien Preeklamsia Berat

Objective : To determine the difference adiponectin serum levels in pregnant patient with severe preeclampsia and normotency in Manado. Methods : This study is a cross sectional study which the number of samples obtained was 52 samples in which the sample was divided into 26 pregnant samples with severe preeclampsia and 26 control samples. Samples were taken from Prof. dr. R. D. Kandou Manado Hospital and network hospitals around Manado within the inclusion and exclusion criteria. All patients were explained about the research procedure and singning the informed consent and take a blood sample by using the ELIZA method. After the data is collected, it is entered into the SPSS version 23.0 program for data analysis. Results : There was a significant relationship between adiponection serum levels with the incidency of severe preeclampsia and normotency. But for body mass index variables there were no significant differences by using T test (independent sample) in each severe preeclampsia and normotency pregnancy group where p=0.903. Body mass index, height, weight, and weight gain during pregnancy showed that there is no difference between cases and controls (p>0.05) which means that body mass index is not related to the stete of the severe preeclampsia and normotency. Conclusions : There was no relationship between BMI, age, parity, smoking, baby outcomes, delivery method and gestational age with the incidence of severe preeclampsia and normotency against adiponectin in this study. Keywords: adiponectin, obstetrics, preeclampsia.   Abstrak Tujuan : Untuk mengetahui perbedaan kadar adiponektin serum pada pasien hamil preeklamsia berat dengan hamil normal di Kota Manado. Metode : Studi ini merupakan studi potong lintang.  Jumlah Sampel yang didapatkan sebesar 52 sampel dimana sampel dibagi menjadi 26 sampel hamil dengan preeklamsia berat dan 26 sampel kontrol. Sampel diambil dari RSUP Prof. dr. R. D. Kandou Manado dan rumah sakit jejaring sekitar manado yang memenuhi kriteria inklusi dan eksklusi. Semua pasien dijelaskan mengenai prosedur penelitian dan penandatanganan inform consent baru dilakukan pengambilan sampel darah untuk dilakukan pemeriksaan laboratorium dengan menggunakan metode ELISA. Setelah data dikumpulkan, maka dimasukkan ke dalam program SPSS versi 23.0 untuk data analisis. Hasil : Perhitungan dengan menggunakan uji statistik Mann - Whitney menunjukkan bahwa terdapat perbedaan bermakna nilai rata-rata kadar adiponektin pada pasien hamil normal dengan pasien PEB     (p = 0,000). Adanya hubungan bermakna kadar adiponektin dengan kejadian preeklamsia berat. Namun untuk variabel IMT yang dilakukan secara uji t (sampel independen) didapatkan kesimpulan tidak terdapat perbedaan bermakna pada masing-masing kelompok normotensi dan kelompok preeklamsia berat di mana p= 0,903, indeks massa tubuh, tinggi badan, berat badan, serta pertambahan berat badan selama kehamilan tidak berbeda antara kasus dan kontrol (p>0,5). Ini berarti bahwa IMT tidak berhubungan dengan keadaan terjadinya preeklamsia berat. Kesimpulan: Tidak didapatkan hubungan antara IMT, usia, paritas, merokok, luaran bayi, cara persalinan dan usia kehamilan dengan kejadian preeklamsia berat dan normotensi  terhadap adiponektin pada penelitian ini. Kata kunci : adiponektin,  obstetri, preeklamsia

Gambaran Persalinan Pada Program Jampersal Di RSU Prof. Dr. R. D Kandou Manado

: Jampersal stand for financing service childbirth is covering to examine the pregnancy, birth aid, the parturition, including family planning service post delivery and newborn service performed by health professionals in health facilities. The purpose of this study was to know description of childbirth on Jampersal program at Prof. Dr. R. D Kandou. This research used retrospective descriptive methods. The sample in this study were all of the birthing mother who used Jampersal at Prof. Dr. R. D Kandou general hospital Manado from April to December 2011. This study has shown indicate that there are 2800 delivery cases was found using the Jampersal program from 3561 total of childbirth. Most childbirth which used Jampersal program is followed by multigravida (55,18%) at the age of 20 to 25 years (29,00%). Most woman came directly to the hospital (71,82%) and treated in hospital for more than 3 days (39,11%). Most labors using the Jampersal program were commonly aided spontaneously (66,93%). Conclusion: Description of childbirth on Jampersal program at Prof. Dr. R. D Kandou General Hospital most was followed by multigravida, at the age of 20-25 years, came directly to the hospital, treated for more than 3 days, and aided spontaneously

Levels of 25 Hydroxyvitamin D in Normotensive Pregnancy and Severe Preeclampsia

Objective: To determine the ratio of 25-hydroxyvitamin D levels in normotensive pregnancy and severe preeclampsia.   Methods: This study was an analytic cross-sectional study with t-test. The subject of this study consists of 17 samples normotensive pregnancy and 17 samples severe preeclampsia. This study was conducted and evaluated from August 2016 until December 2016 at Department of Obstetrics and Gynecology Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado and satellite hospital in Manado. Samples were taken from serum as much as 5 ccs and were analyzed using CLIA at Prodia clinical laboratory. Data were analyzed with SPSS version 20.0.   Results: By using the t- test, there were significant differences in 25-hydroxyvitamin D levels between normotensive pregnancy group (24.771  6.9567ng/ml) and severe preeclamptic group (17.712  3.7513ng/ml), p = 0.001.   Conclusion: Levels of 25-hydroxyvitamin D in normotensive pregnancy significantly higher compared to severe preeclampsia so it can be concluded that the levels of 25-hydroxyvitamin D were associated with preeclampsia.   Keywords: 25-hydroxyvitamin D, normotensive, severe preeclampsi

Heme Oxygenase1 Level in Normotensive Pregnancy and Preeclampsia with Severe Features

Objective: To understand the relationship of heme oxygenase-1 (HO-1) level between normotensive pregnancy and preeclampsia with severe features. Method: The cross sectional study was conducted in the Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R. D. Kandou General Hospital Manado. The subjects consisted of 26 pregnant women with normal blood pressure and 26 women with severe features of preeclampsia. We took the patients’ history, general physical examination, and laboratory assessment. The blood samples were taken from normotensive women more than 20 weeks of pregnancy and preeclamptic women with severe features more than 20 weeks of pregnancy. The data obtained was processed using SPSS 20.0 software. We did the nonparametric Mann-Whitney test to analyze the relationship between heme oxygenase-1 (HO-1) level in normotensive pregnancy and preeclampsia with severe features. Result: The level of heme oxygenase-1 (HO-1) in normotensive pregnant women was at 3.24 (SD 0.58) ng/ml (95% CI 3.00-3.47), and the level of heme oxygenase-1 (HO-1) of preeclamptic women with severe features was 3.92 (SD 0.73) ng/ml (95% CI 3.62-4.21). The result of Mann-Whitney test showed p value of 0.001 which meant that there was significant difference in the level of heme oxygenase- 1 (HO-1) between normotensive women and pre-eclamptic women with severe features. Conclusion: There was the relationship between the level of heme oxygenase-1 (HO-1) and the incidence of preeclampsia with severe features. Keywords: heme oxygenase-1 (HO-1), normotensive pregnancy, preeclampsia with severe feature

Secretory Leukocyte Protease Inhibitor in Preterm Labor and Pregnancy

Objective: To investigate the levels of secretory leukocyte protease inhibitor (SLPI) in women with preterm labor and pregnancy.   Methods: SLPI level examination conducted to 32 samples of pregnant women who meet the inclusion and exclusion criteria, consists of 16 preterm labor and 16 preterm pregnancy. Sample analysis carried out in Prodia Laboratory Jakarta. SLPI level examination used ELISA method. The obtained data processed by SPSS software version 20.0 and discussed with existing literature theory.   Results: Mean plasma SLPI level in patients with preterm labor is 30.319 ng/ml and median: 29.950 ng/ml with p value: 0.652, while the mean on preterm pregnancy is 45.975 ng/ml and median: 41.600 ng/ml with p value: 0.005.   Conclusion: There are significant differences of SLPI level between preterm labor and preterm pregnancy. Keywords: preterm labor, preterm pregnancy, SLP

Maternal Serum Interleukin6 Level in Correlation with Preterm Delivery

Objective: To determine the correlation between maternal serum Interleukin-6 (IL-6) serum level with preterm delivery. Methods: We performed an observational cross-sectional study of 30 pregnant women between 21 to 36 week gestational age with and wthout labour (delivery) in Prof. Dr. RD. Kandou Hospital Manado. Samples were collected with consecutive sampling method. Data was analyzed using Mann-Whitney test with significance level of

Creatinine clearance levels are associated with the incidence of preeclampsia

Abstract Objective: Determine thecorrelation between creatinine clearance relationship with preeclampsia incidence. Method: Cross sectional research. Result: Creatinine clearance examination conducted on 60 sample of pregnant women > 20 weeks,30 normotensive samples and 30 preeclampsia samples. The obtained data analyzed using SPSS software version 22.0 and discussed using the existing literature theory. Creatinine clearance average level in normotensive pregnancy 124.650 ± 14.3699ml/minutes/1,73m2and preeclampsia 74.003 ± 23.169ml/minutes/1,73m2. After Mann-Whitney statistical test obtained p value = 0,000. From ROC curve analysis for creatinine clearance obtained sensitivityvalue 100% and specificity 99,53%. Conclusion:There is a significant correlation between the creatinine clearance levels with preeclampsia. Keywords: creatinine clearance, normotensive, preeclampsia.   Abstrak Tujuan: Menentukan hubungan antara creatinine clearance dengan kejadian preeklamsia. Metode: Penelitian potong lintang. Hasil:Dilakukan pemeriksaan creatinine clearance pada 60 sampel ibuhamil > 20 minggu, 30 sampel darah normal dan 30 sampel preeklamsia. Data yang diperoleh dianalisa dengan menggunakan software SPSS versi 22.0 dan dibahas dengan menggunakan  teori literatur yang ada. Kadar rerata creatinine clearance pada kehamilan normotensi 124,650 ± 14,3699 ml / menit / 1,73m2 dan preeklampsia 74,003 ± 23,169 ml / menit / 1,73m2. Setelah uji statistik Mann-Whitney diperoleh nilai p = 0,000. Dari analisis kurva ROC untuk creatinine clearance diperoleh nilai sensitivitas 100% dan spesifisitas 99,53%. Kesimpulan: Ada hubungan yang signifikan  antara creatinine clearance dengan kejadian preeklamsia. Kata kunci: creatinine clearance, normotensi, preeklampsia

The status of probiotics supplementation during pregnancy

Probiotics have been known for their use in medical field for quite a long time. Strong evidences are now available for the use of probiotics in clinical setting. One of the current issues on this topic is the use of probiotics in pregnancy. Recent studies showed that probiotics may be safe and beneficial for prenatal supplementation. In this review, we highlighted several proven use of probiotics supplementation in pregnant women. A few selected strains of probiotics showed promising outcome to prevent preterm labor and preeclampsia, and to reduce atopic eczema but not asthma and wheezing, in offspring of women who had prenatal probiotics supplementation. The mechanism of action responsible for this effect is closely related to the regulation of T cells, although the exact pathways are not defined yet.</p