2 research outputs found
Sister Mary Joseph's nodule: A case of umbilical cutaneous metastasis with signet ring cell histology
The metastasis of a visceral malignancy to the umbilicus is known as
"Sister Mary Joseph′s nodule". It is a rare clinical sign
indicating advanced, metastasizing intraabdominal cancer. We report a
50-year-old man who developed metastatic skin cancer in the form of
semicircular indurated plaque on top of which was a firm mobile rounded
nodule at the umbilical area. Histopathological examination
demonstrated diastase-resistant periodic acid-Schiff and mucicarmine
positive signet ring cells, suggesting gastric carcinoma.
Immunohistochemical staining showed that these cells were positive for
cytokeratins and epithelial membrane antigen, suggesting epithelial
origin