Giant Cell Reparative Granuloma in the Maxilla and Mandibula

Giant cell reparative granuloma is a disease with an unknown etiology, characterized of benign locally aggressive lesions invading mandible and maxilla in the head and neck region. These lesions usually present as a mass and cause deformities at bony structures. The use of various medical and surgical procedures in the treatment of the disease with its rare occurrence makes these lesions interesting. In this case report we present a 47 years old female patient who had a painful swelling in the left lower left jaw and oral cavity since 8 months. After her complaints proceeded despite medical therapy, she has been operated and pathology report confirmed a giant cell reparative granuloma. We also discuss differential diagnosis and the achievements in treatment procedures

Normative values for semicircular canal function with the video head impulse test (vHIT) in healthy adolescents

Background: The vHIT device, which has a mechanism based on measuring the VOR gain, helps us to quickly evaluate six semicircular canals. Aims/Objectives: The aim of this study was to establish normative values for semicircular canal function with the video head impulse test (vHIT) battery in normal adolescents. Material and methods: 100 (50 females, 50 males) individuals aged 11–18 years, with a mean age of 14.99 years, were included in the study. Results: As a result of the vHIT evaluations performed with vHIT Otometrics ICS Impulse A/S Taastrup, Denmark, the mean lateral canal vestibulo-ocular reflex (VOR) gain value was 0.96, the mean anterior canal VOR gain value was 0.89, and the mean posterior canal VOR gain value was 0.87, all of which were within the normal value range. Conclusion and significance: While the VOR gain values and asymmetry values are within the normal value range and are similar to the literature, no statistically significant correlation was observed between these values and age. As a result, the vHIT battery is an easy, fast, and practical test method that can be used in adolescents

Gene Expression Profiles of Tumor Necrosis Factor-alpha and Endothelin-1 in Obstructive Sleep Apnea

Background/Aims: The aim of this study was to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-alpha and endothelin (EDN)-1 and obstructive sleep apnea (OSA). Methods: A prospective, cross-sectional study performed at a tertiary-care academic center; 108 patients with snoring and day-time sleeplessness were included in this study carried out in the Otolaryngology Department. All patients were evaluated with 1-night polysomnography (PSG). There were 63 patients with OSA and 45 patients without OSA. In the OSA group, the median apnea hypopnea index (AHI) was 29.1; in the non-OSA group, the median AHI was 2.1. Blood samples were obtained from all 108 patients for the genetic analysis of the expression of TNF-alpha and EDN-1. PSG findings and gene expression levels were evaluated in both groups. Results: The median (range) age was 46 (20-81) years, BMI 24.9 (15-49), EDN-1 gene expression 0.45 (0.02-67.88) pg/mu L, and TNF-alpha gene expression 1.71 (0.08-59.52) pg/mu L. We found that EDN-1 and TNF-alpha gene expression levels were significantly higher in the OSA group than in the control group (p = 0.009 vs. p < 0.001). Conclusion: EDN-1 and TNF-alpha gene expression levels were associated with the occurrence of OSA. (C) 2018 S. Karger AG, Base