8 research outputs found
Precision measurements of the top quark mass from the Tevatron in the pre-LHC era
The top quark is the heaviest of the six quarks of the Standard Model.
Precise knowledge of its mass is important for imposing constraints on a number
of physics processes, including interactions of the as yet unobserved Higgs
boson. The Higgs boson is the only missing particle of the Standard Model,
central to the electroweak symmetry breaking mechanism and generation of
particle masses. In this Review, experimental measurements of the top quark
mass accomplished at the Tevatron, a proton-antiproton collider located at the
Fermi National Accelerator Laboratory, are described. Topologies of top quark
events and methods used to separate signal events from background sources are
discussed. Data analysis techniques used to extract information about the top
mass value are reviewed. The combination of several most precise measurements
performed with the two Tevatron particle detectors, CDF and \D0, yields a value
of \Mt = 173.2 \pm 0.9 GeV/.Comment: This version contains the most up-to-date top quark mass averag
Clinical correlates of early onset antipsychotic treatment resistance
Background:
There is evidence of heterogeneity within treatment-resistant schizophrenia (TRS), with some people not responding to antipsychotic treatment from illness onset and others becoming treatment-resistant after an initial response period. These groups may have different aetiologies.
Aim:
This study investigates sociodemographic and clinical correlates of early onset of TRS.
Method:
Employing a retrospective cohort design, we do a secondary analysis of data from a cohort of people with TRS attending the South London and Maudsley. Regression analyses were conducted to identify the correlates of the length of treatment to TRS. Predictors included the following: gender, age, ethnicity, problems with positive symptoms, problems with activities of daily living, psychiatric comorbidities, involuntary hospitalisation and treatment with long-acting injectable antipsychotics.
Results:
In a cohort of 164 people with TRS (60% were men), the median length of treatment to TRS was 3 years and 8 months. We observed no cut-off on the length of treatment until TRS presentation differentiating between early and late TRS (i.e. no bimodal distribution). Having mild to very severe problems with hallucinations and delusions at the treatment start was associated with earlier TRS (~19 months earlier). In sensitivity analyses, including only complete cases (subject to selection bias), treatment with a long-acting injectable antipsychotic was additionally associated with later TRS (~15 months later).
Conclusion:
Our findings do not support a clear separation between early and late TRS but rather a continuum of the length of treatment before TRS onset. Having mild to very severe problems with positive symptoms at treatment start predicts earlier onset of TRS