High purity mesoporous gamma-al(2)o(3) from kano kaolin in the presence of polyethylene glycol 6000 (peg-6000) surfactant

Mesoporous gamma-Al2O3 with large surface area and narrow pore size was synthesized from acid-leachates of calcined kaolin in the presence of polyethylene glycol 6000 (PEG-6000) surfactant at room temperature. The synthesized alumina was characterized by X-ray diffraction (XRD), Nitrogen adsorption-desorption, Fourier transform infra-red spectroscopy (FTIR), field emission scanning electron microscopy (FESEM) with energy-dispersive X-ray analysis (EDX), and thermogravimetric-Derivative thermal analysis (TG-DTA). High-purity mesoporous gamma-Al2O3 with large surface area of 365.1 m(2)/g, narrow pore size distribution centred at 5.3 nm and pore volume of 0.46 cm(3)/g was obtained at 500 degrees C. When the calcination temperature has increased to 700 degrees C, the surface area decreased to 272.9 m(2)/g. Crystallite size calculated using Scherer's equation revealed the average size of 4.33 and 4.12 nm for alumina calcined at 500 and 700 degrees C, respectively. The excellent pore structural properties (high surface area and large pore volume) of the synthesized mesoporous gamma-alumina in the present study will allow for higher loading of active catalytic phases, as such it can be used as catalyst support

Evaluating the protective effects of Aurodox in a murine model of Shiga toxin-producing Escherichia coli

Shiga Toxin-Producing E. coli (STEC) are a group of acute small intestine pathogens responsible for foodborne outbreaks of bloody diarrhoea. The expression of Shiga toxins (Stx) carried by STEC can initiate Haemolytic Uremic Syndrome (HUS), a major cause of acute renal failure in children. Here, we investigate the anti-virulence potential of Aurodox - a natural product of Streptomyces goldiniensis. Previously, we have shown that Aurodox downregulates the expression of the T3SS, inhibiting epithelial cell colonisation in vitro. Here, we use the Citrobacter rodentium DBS770 (Cr Stx2dact) model of STEC infection to demonstrate that Aurodox protects mice against Citrobacter rodentium-associated colonic hyperplasia and Stx-mediated renal injury. Given antibiotic-associated dysbiosis of the gut is associated with inflammation and the emergence of opportunistic pathogens, we examined the effect of Aurodox on the faecal bacteriome. We show that although the microbial community is altered following Aurodox treatment, changes are distinct from those associated with traditional antibiotic therapies

Evaluating the protective effects of Aurodox in a murine model of Shiga toxin-producing Escherichia coli

Shiga Toxin-Producing E. coli (STEC) are a group of acute small intestine pathogens responsible for foodborne outbreaks of bloody diarrhoea. The expression of Shiga toxins (Stx) carried by STEC can initiate Haemolytic Uremic Syndrome (HUS), a major cause of acute renal failure in children. Here, we investigate the anti-virulence potential of Aurodox - a natural product of Streptomyces goldiniensis. Previously, we have shown that Aurodox downregulates the expression of the T3SS, inhibiting epithelial cell colonisation in vitro. Here, we use the Citrobacter rodentium DBS770 (Cr Stx2dact) model of STEC infection to demonstrate that Aurodox protects mice against Citrobacter rodentium-associated colonic hyperplasia and Stx-mediated renal injury. Given antibiotic-associated dysbiosis of the gut is associated with inflammation and the emergence of opportunistic pathogens, we examined the effect of Aurodox on the faecal bacteriome. We show that although the microbial community is altered following Aurodox treatment, changes are distinct from those associated with traditional antibiotic therapies

Influence of Water Immersion on Stability of AC-WC Mixed with Gondorukem Additional Material

Abstract One of the treatments that can be given to asphalt mixtures to determine the durability of the mixture is by water immersion. This study aims to analyze the stability value of Marshall mixture of AC-WC (Asphalt Concrete Wearing Course) by using modified Asbuton as a binder and gondorukem as added material due to water immersion. The method used in this research is experimental in the laboratory. AC-WC mixture is produced using modified Asbuton as a binder (Retona Blend 55) at optimum asphalt content of 6.25% and gondorukem as an additive at 0.0% and 2.5% content. The treatment given to the mixture is by soaking water for 0, 1, 3 and 7 days. The treatment given to the mixture is by soaking water for 0, 1, 3 and 7 days. The results showed that the Marshall stability value decreased with increasing water immersion time. Decrease in Marshall stability values that occur in specimens with immersion time of 1, 3 and 7 days for specimens without immersion are 21.34%, 25.56% and 28.25%, respectively.</jats:p