62 research outputs found

    Utilization of inorganic industrial wastes in producing construction ceramics. Review of Russian experience for the years 2000–2015

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    Β© 2016 Elsevier LtdThis paper analyzes the significant scientific publications worldwide for the last 15Β years concerning construction ceramics (predominantly brick) made with various inorganic industrial wastes added to the ceramic raw material for the improvement of properties and for eco-friendly disposal. The information gap resulting from the lack of mentions of the Russian publications on this subject in English-language reviews is filled. The paper includes brief summaries of 34 dissertations and 29 patents issued in Russia since 2000. The waste additives described in these summaries are grouped by origin type (mining industry waste, ore enrichment waste, metallurgical waste, sludge, ashes, cullet, large-capacity building wastes and waste from various chemical production processes) with the ceramic mixture compositions, molding and firing conditions, final strength, water absorption and other parameters of the final ceramic samples reported. Russian scientists have expanded the nomenclature of each group of wastes significantly upon addition to the list described in English-language reviews for 2000–2015. References to the recent Russian developments in the field of ecological management in ceramic industry are provided

    Magnetic properties of (La<inf>0.7</inf>Sr<inf>0.3</inf>MnO<inf>3</inf>)<inf>x</inf>(CaCu<inf>3</inf>Ti<inf>4</inf>O<inf>12</inf>)<inf>1βˆ’x</inf>nanostructured composites

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    Β© 2017 Elsevier B.V. (La 0.7 Sr 0.3 MnO 3 ) x (CaCu 3 Ti 4 O 12 ) 1βˆ’x (0.01 ≀ x ≀ 0.3) nanostructured composites with La 0.7 Sr 0.3 MnO 3 (LSMO) microinclusions in CaCu 3 Ti 4 O 12 (CCTO) matrix were synthesized using a solid state method. The structural and microstructural details were studied by X-ray diffraction (XRD), X-ray fluorescence (XFA), scaning electron microscope (SEM) and transmission electron microscope (TEM) techniques. The magnetic properties were studied by electron spin resonance (ESR) and magnetometry methods. In the concentration range 0.01Β  < Β xΒ  < Β 0.1 physical properties of composites differ from the properties of the individual components CCTO or LSMO. The Curie temperature of the ferromagnetic phase for all concentrations is T C Β =Β 315Β K, that is less at 50Β K than in pure LSMO. The Weiss constant of the paramagnetic phase has the strong concentration dependance. The observed mutual influence on the magnetic properties of both components can be tentatively attributed to the interface exchange interactions between them, hinting a possible magnetic proximity effect

    Ultrasound-assisted extrusion of construction ceramic samples

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    Β© 2017 Elsevier Ltd and Techna Group S.r.l.The conditions for a decrease in friction during ceramic brick production between a mixture and an extruder die under the influence of 20–30Β kHz ultrasound applied to the die are calculated. An optimum design of a die used to mold 30Β mm diameter cylindrical samples with a resonance in this frequency range is selected using computer modeling. From the results, a titanium die is fabricated and tested on a Verdes–050 (Spain) laboratory extruder using an ultrasonic magnetostrictive transducer with a power of 1.5Β kW (Inlab-Ultrazvuk, Russia). A 12% reduction in extrusion pressure, a 20% acceleration of molding and a positive influence on the properties of the ceramics were found. The surface of the ceramic samples was covered by craters with diameters of approximately 10Β Β΅m due to the boiling of water, and the porosity of the main body of the samples decreased. This technique prevents the undesirable rapid drying of the surface when the samples exit the die and stabilizes the strength of the fired samples. The color remained unchanged, the water absorption decreased, the density, strength and resistance to frost increased. Ultrasonic extrusion increased the accuracy of the strength tests of construction ceramics, indicating the prospect of ultrasonic die development for industrial extruders for bricks, facing tiles and roof tiles

    Markers of kidney damage in the diagnosis of infectious-inflammatory in patients with urolithiasis after contact ureterolithotripsy

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    Currently one of the main methods of treatment of patients with ureteral stones is contact ureterolithotripsy (CUlT). despite the high effectiveness of the method, the problem of early detection and prevention of exacerbation of inflammatory complications of nephrolithiasis remains urgent. To improve the diagnosis of pyelonephritis after CUlT in patients with urolithiasis, a study of the diagnostic efficacy of neutrophil gelatinase-associated lipocalin (NGAl), cystatin C, Ξ²2-microglobulin, and interleukin-18 was performed in 123 patients with ureteral stones. The greatest value in preoperative diagnostics of pyelonephritis was demonstrated for serum NGAl of blood, urine NGAl, and urine Ξ²2-microglobulin. The most significant increase during early term (2 hours) after CUlT was observed for urine Ξ²2-microglobulin and Il-18. The concentration of urine NGAl among all the studied markers remained elevated for a relatively longer period.Одним ΠΈΠ· основных ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² лСчСния ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с камнями ΠΌΠΎΡ‡Π΅Ρ‚ΠΎΡ‡Π½ΠΈΠΊΠΎΠ² Π² настоящСС врСмя являСтся Ρ‚Ρ€Π°Π½ΡΡƒΡ€Π΅Ρ‚Ρ€Π°Π»ΡŒΠ½Π°Ρ контактная урСтСролитотрипсия (ΠšΠ›Π’). НСсмотря Π½Π° Π²Ρ‹ΡΠΎΠΊΡƒΡŽ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΌΠ΅Ρ‚ΠΎΠ΄Π°, остаСтся Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΠΉ ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠ° Ρ€Π°Π½Π½Π΅Π³ΠΎ выявлСния ΠΈ прСдупрСТдСния обострСния Π²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… ослоТнСний Π½Π΅Ρ„Ρ€ΠΎΠ»ΠΈΡ‚ΠΈΠ°Π·Π°. Π‘ Ρ†Π΅Π»ΡŒΡŽ ΡƒΠ»ΡƒΡ‡ΡˆΠ΅Π½ΠΈΡ диагностики ΠΏΠΈΠ΅Π»ΠΎΠ½Π΅Ρ„Ρ€ΠΈΡ‚Π° послС ΠšΠ›Π’ Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ΡƒΡ€ΠΎΠ»ΠΈΡ‚ΠΈΠ°Π·ΠΎΠΌ исслСдованиС диагностичСской эффСктивности Π»ΠΈΠΏΠΎΠΊΠ°Π»ΠΈΠ½Π°, ассоциированного с ΠΆΠ΅Π»Π°Ρ‚ΠΈΠ½Π°Π·ΠΎΠΉ Π½Π΅ΠΉΡ‚Ρ€ΠΎΡ„ΠΈΠ»ΠΎΠ² (НГАЛ), цистатина Π‘, Ξ²2-ΠΌΠΈΠΊΡ€ΠΎΠ³Π»ΠΎΠ±ΡƒΠ»ΠΈΠ½Π° ΠΈ ΠΈΠ½Ρ‚Π΅Ρ€Π»Π΅ΠΉΠΊΠΈΠ½Π°-18 ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Ρƒ 123 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с камнями ΠΌΠΎΡ‡Π΅Ρ‚ΠΎΡ‡Π½ΠΈΠΊΠΎΠ². Наибольшая Ρ†Π΅Π½Π½ΠΎΡΡ‚ΡŒ Π² Π΄ΠΎΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ диагностикС ΠΏΠΈΠ΅Π»ΠΎΠ½Π΅Ρ„Ρ€ΠΈΡ‚Π° продСмонстрирована для НГАЛ ΠΊΡ€ΠΎΠ²ΠΈ, НГАЛ ΠΈ Ξ²2ΠΌΠΈΠΊΡ€ΠΎΠ³Π»ΠΎΠ±ΡƒΠ»ΠΈΠ½Π° ΠΌΠΎΡ‡ΠΈ. Π‘Π°ΠΌΠΎΠ΅ Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ΅ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ Π² Ρ€Π°Π½Π½ΠΈΠ΅ сроки (Ρ‡Π΅Ρ€Π΅Π· 2 часа) послС ΠšΠ›Π’ наблюдалось для Ξ²2ΠΌΠΈΠΊΡ€ΠΎΠ³Π»ΠΎΠ±ΡƒΠ»ΠΈΠ½Π° ΠΈ Π˜Π›-18 ΠΌΠΎΡ‡ΠΈ. концСнтрация НГАЛ ΠΌΠΎΡ‡ΠΈ срСди всСх ΠΈΠ·ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… ΠΌΠ°Ρ€ΠΊΠ΅Ρ€ΠΎΠ² ΠΎΡΡ‚Π°Π²Π°Π»Π°ΡΡŒ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½Π½ΠΎΠΉ ΡΡ€Π°Π²Π½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ Π½Π° Π±ΠΎΠ»Π΅Π΅ Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ срок

    ΠŸΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠ° послСопСрационных ослоТнСний послС Ρ€ΠΎΠ±ΠΎΡ‚-ассистированной Ρ‚Ρ€Π°Π½ΡΠ°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡŒΠ½ΠΎΠΉ ΠΏΡ€Π΅ΠΏΠ΅Ρ€ΠΈΡ‚ΠΎΠ½Π΅Π°Π»ΡŒΠ½ΠΎΠΉ пластики: клиничСский случай

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    Introduction. Inguinal hernia repair is one of the most common elective surgeries today. In our clinic, the majority of inguinal hernia repairs are performed laparoscopically. The most frequent complication after transabdominal preperitoneal inguinal hernia repair is postoperative seroma.Materials and methods. A 35-year-old patient C. with a right-sided inguinal hernia sought medical care in our clinic. He underwent robot-assisted TAPP with fluorescence lymphography using indocyanine green (ICG).Results and discussion. The present paper describes the possible relationship between intraoperative damage of the lymphatic vessels within the spermatic cord induced by robot-assisted transabdominal preperitoneal inguinal hernia repair and postoperative development of inguinal seroma. 5 mg/ml of indocyanine green was injected into the testicle on the side with the hernial bulge to visualize the lymphatic vessels. In this case such procedure is safe and feasible. Due to the tight fusion of the hernia sac with two visualized lymphatic vessels, they were excised during surgery. In the early postoperative period, an ultrasound scan revealed a subclinical seroma in the inguinal region of approximately 10 ml.Conclusion. A case series of ICG fluorescence lymphography during robot-assisted TAPP should be performed further to elucidate the relationship between lymphatic vessel damage and hydrocele.Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅. Одной ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ часто выполняСмых ΠΏΠ»Π°Π½ΠΎΠ²Ρ‹Ρ… ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΉ Π½Π° сСгодня являСтся ΠΏΠ°Ρ…ΠΎΠ²ΠΎΠ΅ грыТСсСчСниС. Π’ нашСй ΠΊΠ»ΠΈΠ½ΠΈΠΊΠ΅ бóльшая Ρ‡Π°ΡΡ‚ΡŒ ΠΏΠ°Ρ…ΠΎΠ²Ρ‹Ρ… грыТСсСчСний выполняСтся лапароскопичСским ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ. НаиболСС частым ослоТнСниСм послС Ρ‚Ρ€Π°Π½ΡΠ°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡŒΠ½ΠΎΠΉ ΠΏΡ€Π΅ΠΏΠ΅Ρ€ΠΈΡ‚ΠΎΠ½Π΅Π°Π»ΡŒΠ½ΠΎΠΉ пластики ΠΏΠ°Ρ…ΠΎΠ²Ρ‹Ρ… Π³Ρ€Ρ‹ΠΆ являСтся Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΠ΅ послСопСрационных сСром.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ нашС ΠΎΡ‚Π΄Π΅Π»Π΅Π½ΠΈΠ΅ обратился ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ Π‘. 35 Π»Π΅Ρ‚ с правостороннСй ΠΏΠ°Ρ…ΠΎΠ²ΠΎΠΉ Π³Ρ€Ρ‹ΠΆΠ΅ΠΉ. Π•ΠΌΡƒ Π±Ρ‹Π»Π° Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½Π° Ρ€ΠΎΠ±ΠΎΡ‚-ассистированная ВАРР с флуорСсцСнтной Π»ΠΈΠΌΡ„ΠΎΠ³Ρ€Π°Ρ„ΠΈΠ΅ΠΉ с ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΈΠ½Π΄ΠΎΡ†ΠΈΠ°Π½ΠΈΠ½Π° Π·Π΅Π»Π΅Π½ΠΎΠ³ΠΎ (ICG).Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ обсуТдСниС. Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ описываСтся возмоТная связь ΠΌΠ΅ΠΆΠ΄Ρƒ ΠΈΠ½Ρ‚Ρ€Π°ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ Ρ‚Ρ€Π°Π²ΠΌΠΎΠΉ лимфатичСских сосудов Π² составС сСмСнного ΠΊΠ°Π½Π°Ρ‚ΠΈΠΊΠ° Π²ΠΎ врСмя выполнСния Ρ€ΠΎΠ±ΠΎΡ‚-ассистированной Ρ‚Ρ€Π°Π½ΡΠ°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡŒΠ½ΠΎΠΉ ΠΏΡ€Π΅ΠΏΠ΅Ρ€ΠΈΡ‚ΠΎΠ½Π΅Π°Π»ΡŒΠ½ΠΎΠΉ пластики ΠΏΠ°Ρ…ΠΎΠ²ΠΎΠΉ Π³Ρ€Ρ‹ΠΆΠΈ ΠΈ Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ΠΌ сСром ΠΏΠ°Ρ…ΠΎΠ²ΠΎΠΉ области Π² послСопСрационном ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π΅. Π‘ Ρ†Π΅Π»ΡŒΡŽ Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈΠΈ лимфатичСских сосудов Π±Ρ‹Π» использован ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ ΠΈΠ½Π΄ΠΎΡ†ΠΈΠ°Π½ΠΈΠ½ Π·Π΅Π»Π΅Π½Ρ‹ΠΉ 5 ΠΌΠ³/ΠΌΠ», ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΉ Π±Ρ‹Π» Π²Π²Π΅Π΄Π΅Π½ Π² яичко Π½Π° сторонС Π³Ρ€Ρ‹ΠΆΠ΅Π²ΠΎΠ³ΠΎ выпячивания. Данная ΠΏΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Π° бСзопасна ΠΈ Π²Ρ‹ΠΏΠΎΠ»Π½ΠΈΠΌΠ° Π² Π΄Π°Π½Π½ΠΎΠΌ случаС. Π’ связи с ΠΏΠ»ΠΎΡ‚Π½Ρ‹ΠΌ сращСниСм Π³Ρ€Ρ‹ΠΆΠ΅Π²ΠΎΠ³ΠΎ мСшка ΠΈ Π΄Π²ΡƒΡ… Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… лимфатичСских сосудов Π² Ρ…ΠΎΠ΄Π΅ ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΈ послСдниС Π±Ρ‹Π»ΠΈ иссСчСны. Π’ Ρ€Π°Π½Π½Π΅ΠΌ послСопСрационном ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π΅ с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΡƒΠ»ΡŒΡ‚Ρ€Π°Π·Π²ΡƒΠΊΠΎΠ²ΠΎΠ³ΠΎ исслСдования выявлСна субклиничСская сСрома Π² ΠΏΠ°Ρ…ΠΎΠ²ΠΎΠΉ области объСмом ΠΎΠΊΠΎΠ»ΠΎ 10 ΠΌΠ».Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π’ качСствС ΡΠ»Π΅Π΄ΡƒΡŽΡ‰Π΅Π³ΠΎ шага для выяснСния связи ΠΌΠ΅ΠΆΠ΄Ρƒ ΠΏΠΎΠ²Ρ€Π΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ΠΌ лимфатичСских сосудов ΠΈ водянкой яичка слСдуСт провСсти ΡΠ΅Ρ€ΠΈΡŽ случаСв флуорСсцСнтной Π»ΠΈΠΌΡ„ΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ ICG Π²ΠΎ врСмя Ρ€ΠΎΠ±ΠΎΡ‚-ассистированной ВАРР

    Robot-assisted pelvic evisceration for locally advanced cervical cancer. First experience

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    Pelvic evacuation in recent years has ceased to be used as a palliative method and has proved to be an effective method of surgical treatment of locally advanced pelvic tumors. Performing these operations with minimally invasive methods helps to reduce the number of postoperative complications and improve the quality of life. Purpose of the study. demonstrate the feasibility of performing robot-assisted pelvic evisceration and compare perioperative parameters with the experience of open pelvic eviscerations. Materials and methods. A 44-year-old woman with progressive local advanced cervical cancer, with a complication of the tumor process, presented by bilateral hydronephrosis. The patient was provided with an anterior robot-assisted PE with the formation ileoconduit by the Brikker method. Results. The total operation time was 515 min, the time in the console was 430 min. The estimated loss of blood was 600 ml, and the stay in the intensive care unit (ICU) - 1 day, the patient was discharged on the 7th day after the operationΠ’Π²Π΅Π΄Π΅Π½ΠΈΠ΅. ЭвисцСрация ΠΌΠ°Π»ΠΎΠ³ΠΎ Ρ‚Π°Π·Π° Π² послСдниС Π³ΠΎΠ΄Ρ‹ пСрСстала ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Ρ‚ΡŒΡΡ Π² качСствС ΠΏΠ°Π»Π»ΠΈΠ°Ρ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΌΠ΅Ρ‚ΠΎΠ΄Π° ΠΈ Π·Π°Ρ€Π΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°Π»Π° сСбя ΠΊΠ°ΠΊ эффСктивный ΠΌΠ΅Ρ‚ΠΎΠ΄ хирургичСского лСчСния мСстно-распространСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ ΠΌΠ°Π»ΠΎΠ³ΠΎ Ρ‚Π°Π·Π°. Π’Ρ‹ΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ этих ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΉ с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ минимально ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½Ρ‹Ρ… ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² ΠΏΠΎΠΌΠΎΠ³Π°Π΅Ρ‚ ΡΠ½ΠΈΠ·ΠΈΡ‚ΡŒ количСство послСопСрационных ослоТнСний ΠΈ ΡƒΠ»ΡƒΡ‡ΡˆΠΈΡ‚ΡŒ качСство ΠΆΠΈΠ·Π½ΠΈ. ЦСль исслСдования. ΠŸΡ€ΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡ‚Ρ€ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Ρ†Π΅Π»Π΅ΡΠΎΠΎΠ±Ρ€Π°Π·Π½ΠΎΡΡ‚ΡŒ выполнСния роботассистированной эвисцСрации ΠΌΠ°Π»ΠΎΠ³ΠΎ Ρ‚Π°Π·Π° ΠΈ ΡΡ€Π°Π²Π½ΠΈΡ‚ΡŒ ΠΏΠ΅Ρ€ΠΈΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½Ρ‹Π΅ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ с ΠΎΠΏΡ‹Ρ‚ΠΎΠΌ ΠΎΡ‚ΠΊΡ€Ρ‹Ρ‚Ρ‹Ρ… эвисцСраций ΠΌΠ°Π»ΠΎΠ³ΠΎ Ρ‚Π°Π·Π°. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠŸΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΊΠ΅, 44-Π»Π΅Ρ‚Π½Π΅ΠΉ ΠΆΠ΅Π½Ρ‰ΠΈΠ½Π΅ с ΠΏΡ€ΠΎΠ³Ρ€Π΅ΡΡΠΈΡ€ΡƒΡŽΡ‰ΠΈΠΌ мСстно-распространСнным Ρ€Π°ΠΊΠΎΠΌ шСйки ΠΌΠ°Ρ‚ΠΊΠΈ, с ослоТнСниСм ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ процСсса, прСдставлСнным двусторонним Π³ΠΈΠ΄Ρ€ΠΎΠ½Π΅Ρ„Ρ€ΠΎΠ·ΠΎΠΌ, Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½Π° пСрСдняя Ρ€ΠΎΠ±ΠΎΡ‚-ассистированная Π­ΠœΡ‚ с Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈΠ»Π΅ΠΎΠΊΠΎΠ½Π΄ΡƒΠΈΡ‚Π° ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π‘Ρ€ΠΈΠΊΠΊΠ΅Ρ€Π°. Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠΎΠ±Ρ‰Π΅Π΅ врСмя Ρ€Π°Π±ΠΎΡ‚Ρ‹ составляло 515 ΠΌΠΈΠ½, консольноС врСмя составляло 430 ΠΌΠΈΠ½. оцСнСнная потСря ΠΊΡ€ΠΎΠ²ΠΈ составляла 600 ΠΌΠ», Π° ΠΏΡ€Π΅Π±Ρ‹Π²Π°Π½ΠΈΠ΅ Π² ΠΎΡ‚Π΄Π΅Π»Π΅Π½ΠΈΠΈ Ρ€Π΅Π°Π½ΠΈΠΌΠ°Ρ†ΠΈΠΈ ΠΈ интСнсивной Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ – 1 сутки, ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΊΠ° выписана Π½Π° 7 сутки послС ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈ

    КомплСкс ΠΈΠ½Π΄ΠΎΡ†ΠΈΠ°Π½ΠΈΠ½Π° Π·Π΅Π»Π΅Π½ΠΎΠ³ΠΎ с Π°Ρ€Π³ΠΈΠ½ΠΈΠ½-Π³Π»ΠΈΡ†ΠΈΠ½-аспарагиновой кислотой ΠΊΠ°ΠΊ Π½ΠΎΠ²Ρ‹ΠΉ ΠΌΠ΅Ρ‚ΠΎΠ΄ ΠΈΠ½Ρ‚Ρ€Π°ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΏΡ€ΠΈ Ρ€Π΅Π·Π΅ΠΊΡ†ΠΈΠΈ Ρ€Π°ΠΊΠ° ΠΌΠΎΡ‡Π΅Π²ΠΎΠ³ΠΎ пузыря

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    Introduction. Bladder cancer is one of the most common malignancies in humans, causing significant economic and social damage. In the connection, it is proposed to use a highly sensitive bladder cancer detection method, which also detects residual tumours. Additionally, the method can be used to determine the boundaries of the bladder tumour, namely through intraoperative fluorescence molecular imaging. The target agent was synthesised earlier with indocyanine green-arginine-glycine-aspartic acid, which is an integrin avß3-targeted in in vitro and in vivo bladder cancer models.Materials and methods. The toxicity of indocyanine green-arginine-glycine-aspartic acid (Agac-IG) was measured using the MTT-test. Urothelial carcinoma cell lines were introduced in Female BALB/nu and MB49 mice by means of tumour xenografts via injection in the back of the elbow area. Tumour growth was observed on a daily basis and tested by magnetic resonance imaging until it became suitable for in vivo experiments. Then, all the laboratory animals were divided into 2 groups: ig and AGAk-ig (150 ΞΌl, 0.2 mg/ml for all mice). Following this, the tumour was surgically removed. The removed tissue was subjected to a fluorescent microscopy on the basis of infrared-spectrum and histologic studies.Results. Operations carried out on subcutaneous and orthotopic mouse models under the control of fluorescent imaging using AGAk-IG demonstrate the effectiveness of using a targeted tumour sample to achieve consistent and accurate RMP-resection. Operations under the control of BIC-spectrometry have demonstrated that the proposed substance can effectively help surgeons to locate tumours, determine their edges and constantly check the presence of tumour residues during surgery.Conclusion. The findings demonstrated the high efficiency of AGAk-IG as a potential molecular fluorescent agent for tumour-specific intraoperative imaging in bladder cancer resection, as well as offering great potential for further clinical studies.Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅. Π Π°ΠΊ ΠΌΠΎΡ‡Π΅Π²ΠΎΠ³ΠΎ пузыря являСтся ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ распространСнных злокачСствСнных Π½ΠΎΠ²ΠΎΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠΉ, приносящих Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ экономичСский ΠΈ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹ΠΉ ΡƒΡ‰Π΅Ρ€Π± Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΡƒ. Для Ρ€Π΅ΡˆΠ΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡ‹ ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½ΠΎ использованиС Π²Ρ‹ΡΠΎΠΊΠΎΡ‡ΡƒΠ²ΡΡ‚Π²ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Ρ‚ΠΎΠ΄Π° обнаруТСния Ρ€Π°ΠΊΠ° ΠΌΠΎΡ‡Π΅Π²ΠΎΠ³ΠΎ пузыря, выявлСния остаточной ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ ΠΈ опрСдСлСния Π³Ρ€Π°Π½ΠΈΡ† ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ ΠΌΠΎΡ‡Π΅Π²ΠΎΠ³ΠΎ пузыря β€” ΠΈΠ½Ρ‚Ρ€Π°ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ Ρ„Π»ΡŽΠΎΡ€Π΅ΡΡ†Π΅Π½Ρ‚Π½ΠΎΠΉ молСкулярной Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ. Π Π°Π½Π΅Π΅ Π½Π°ΠΌΠΈ синтСзирован Ρ‚Π°Ρ€Π³Π΅Ρ‚Π½Ρ‹ΠΉ Π°Π³Π΅Π½Ρ‚ β€” ΠΈΠ½Π΄ΠΎΡ†ΠΈΠ°Π½ΠΈΠ½Π° Π·Π΅Π»Π΅Π½ΠΎΠ³ΠΎ-Π°Ρ€Π³ΠΈΠ½ΠΈΠ½-Π³Π»ΠΈΡ†ΠΈΠ½-аспарагиновая кислота, которая являСтся ΠΈΠ½Ρ‚Π΅Π³Ρ€ΠΈΠ½ avß3-Ρ†Π΅Π»Π΅Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½ΠΎΠΉ Π² in vitro ΠΈ in vivo модСлях Ρ€Π°ΠΊΠ° ΠΌΠΎΡ‡Π΅Π²ΠΎΠ³ΠΎ пузыря.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ΠΎΠΊΡΠΈΡ‡Π½ΠΎΡΡ‚ΡŒ ΠΈΠ½Π΄ΠΎΡ†ΠΈΠ°Π½ΠΈΠ½Π° Π·Π΅Π»Π΅Π½ΠΎΠ³ΠΎ-Π°Ρ€Π³ΠΈΠ½ΠΈΠ½Π°-Π³Π»ΠΈΡ†ΠΈΠ½-аспарагиновой кислоты (АГАк-Π˜Π¦Π—) Π±Ρ‹Π»Π° ΠΈΠ·ΠΌΠ΅Ρ€Π΅Π½Π° с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ МВВ-тСста. Π‘Π°ΠΌΠΊΠΈ BALB/nu ΠΈ ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ Π»ΠΈΠ½ΠΈΠΈ MB49 ΡƒΡ€ΠΎΡ‚Π΅Π»ΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ ΠΊΠ°Ρ€Ρ†ΠΈΠ½ΠΎΠΌΡ‹ ΠΌΡ‹ΡˆΠΈ использовали для установки ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²Ρ‹Ρ… ксСнотрансплантатов, ΠΈΠ½ΡŠΠ΅ΠΊΡ†ΠΈΠ΅ΠΉ Π² заднюю Π»ΠΎΠΊΡ‚Π΅Π²ΡƒΡŽ ΠΎΠ±Π»Π°ΡΡ‚ΡŒ. Рост ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ наблюдался Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ ΠΈ провСрялся ΠΌΠ°Π³Π½ΠΈΡ‚Π½ΠΎ-рСзонансной Ρ‚ΠΎΠΌΠΎΠ³Ρ€Π°Ρ„ΠΈΠ΅ΠΉ, ΠΏΠΎΠΊΠ° ΠΎΠ½ Π½Π΅ становился подходящим для экспСримСнтов in vivo. Π”Π°Π»Π΅Π΅ Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Π΅ ΠΆΠΈΠ²ΠΎΡ‚Π½Ρ‹Π΅ Π±Ρ‹Π»ΠΈ Ρ€Π°Π·Π΄Π΅Π»Π΅Π½Ρ‹ Π½Π° 2 Π³Ρ€ΡƒΠΏΠΏΡ‹: Π˜Π¦Π— ΠΈ АГАк-Π˜Π¦Π— (150 ΠΌΠΊΠ», 0,2 ΠΌΠ³/ΠΌΠ» для всСх ΠΌΡ‹ΡˆΠ΅ΠΉ). Π—Π°Ρ‚Π΅ΠΌ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡŒ хирургичСскоС ΡƒΠ΄Π°Π»Π΅Π½ΠΈΠ΅ ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ. Π£Π΄Π°Π»Π΅Π½Π½ΡƒΡŽ Ρ‚ΠΊΠ°Π½ΡŒ ΠΏΠΎΠ΄Π²Π΅Ρ€Π³Π°Π»ΠΈ Ρ„Π»ΡŽΠΎΡ€Π΅ΡΡ†Π΅Π½Ρ‚Π½ΠΎΠΉ микроскопии Π½Π° основС Π±Π»ΠΈΠΆΠ½Π΅Π²ΠΎΠ»Π½ΠΎΠ²ΠΎΠ³ΠΎ инфракрасного спСктра ΠΈ гистологичСскому исслСдованию.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠžΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΈ, ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ‹Π΅ Π½Π° ΠΏΠΎΠ΄ΠΊΠΎΠΆΠ½ΠΎΠΉ ΠΈ ортотопичСской ΠΌΡ‹ΡˆΠΈΠ½Ρ‹Ρ… модСлях ΠΏΠΎΠ΄ ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»Π΅ΠΌ Ρ„Π»ΡŽΠΎΡ€Π΅ΡΡ†Π΅Π½Ρ‚Π½ΠΎΠΉ Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ с использованиСм АГАк-Π˜Π¦Π—, Π΄Π΅ΠΌΠΎΠ½ΡΡ‚Ρ€ΠΈΡ€ΡƒΡŽΡ‚ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ использования ΠΏΡ€ΠΈΡ†Π΅Π»ΡŒΠ½ΠΎΠΉ ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²ΠΎΠΉ ΠΏΡ€ΠΎΠ±Ρ‹ для достиТСния Π°ΠΊΠΊΡƒΡ€Π°Ρ‚Π½ΠΎΠΉ ΠΈ Ρ‚ΠΎΡ‡Π½ΠΎΠΉ РМП Ρ€Π΅Π·Π΅ΠΊΡ†ΠΈΠΈ. ΠžΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΈ ΠΏΠΎΠ΄ ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»Π΅ΠΌ Π‘Π˜Πš-спСктромСтрии продСмонстрировали, Ρ‡Ρ‚ΠΎ ΠΏΡ€Π΅Π΄Π»Π°Π³Π°Π΅ΠΌΠΎΠ΅ вСщСство ΠΌΠΎΠΆΠ΅Ρ‚ эффСктивно ΠΏΠΎΠΌΠΎΡ‡ΡŒ Ρ…ΠΈΡ€ΡƒΡ€Π³Π°ΠΌ Π½Π°ΠΉΡ‚ΠΈ ΠΎΠΏΡƒΡ…ΠΎΠ»ΡŒ, ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΠΈΡ‚ΡŒ ΠΊΡ€Π°ΠΉ ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ ΠΈ постоянно ΠΏΡ€ΠΎΠ²Π΅Ρ€ΡΡ‚ΡŒ Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ остатков ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ Π²ΠΎ врСмя ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΈ.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±Ρ€Π°Π·ΠΎΠΌ, ΠΏΠΎ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌ исслСдования продСмонстрирована высокая ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ АГАк-Π˜Π¦Π— ΠΊΠ°ΠΊ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ молСкулярного Ρ„Π»ΡŽΠΎΡ€Π΅ΡΡ†Π΅Π½Ρ‚Π½ΠΎΠ³ΠΎ Π°Π³Π΅Π½Ρ‚Π° для опухолСспСцифичной ΠΈΠ½Ρ‚Ρ€Π°ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΏΡ€ΠΈ Ρ€Π΅Π·Π΅ΠΊΡ†ΠΈΠΈ Ρ€Π°ΠΊΠ° ΠΌΠΎΡ‡Π΅Π²ΠΎΠ³ΠΎ пузыря ΠΈ большой ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π» для провСдСния Π΄Π°Π»ΡŒΠ½Π΅ΠΉΡˆΠΈΡ… клиничСских исслСдований

    ΠœΠΎΡ€Ρ„ΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΠΈΠ΅ аспСкты ΠΏΠΎΠ²Ρ€Π΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΏΡ€ΠΎΠΊΡΠΈΠΌΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΎΡ‚Π΄Π΅Π»Π° ΠΏΠ»Π΅Ρ‡Π΅Π²ΠΎΠΉ кости Ρƒ Ρ€Π°Π·Π½Ρ‹Ρ… возрастных Π³Ρ€ΡƒΠΏΠΏ

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    Introduction. Fracture of the proximal humerus is a common injury that accounts for up to 12 % of all bone fractures and up to 65 % of humeral fractures. 13 % to 16 % of fractures in this segment are multi-fragment with bone impression. This significantly complicates the task of internal fixation. This study aims to analyze the gender and age group distribution of patients with proximal humerus fractures, and morphological aspects of these injuries.Materials and methods. This paper presents a retrospective analysis of the epidemiological and morphological parameters of patients treated surgically for proximal humerus injuries at the Department of Traumatology and Orthopedics of the State Regional Clinical Hospital of the Republic of Bashkortostan β„– 1 in the city of Oktyabrsky in 2010–2016. The total of 191 patients were included in the study, 121 (63.35 %) females and 70 (36.65 %) males.Results and discussions. A signifi cant increase (more than three times) in the number of proximal humerus fractures was recorded in women in the 50–65 age group and in men in the 55–60 age group. The increase in the incidence of this type of injury does not exceed 22.4 % in comparison to the younger age groups. The increase in the number of injuries in question is undoubtedly due to changes in the bone metabolism in women. The analysis of character and morphology of fractures in women of older age groups indicates a greater prevalence of unstable injury of type 1.1.B and 1.1.C according to AO/ASIF classifi cation, which, again, is due to the demineralization of the segment determined by systemic metabolic abnormalities. The fi ndings indicate the need for perioperative monitoring of the bone metabolism parameters.Conclusion.The morphology and types of fractures depend on a patient’s age and bone quality. A signifi cant increase in this pathology in women of perimenopausal age refl ects changes in bone metabolism.Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠŸΠ΅Ρ€Π΅Π»ΠΎΠΌΡ‹ ΠΏΡ€ΠΎΠΊΡΠΈΠΌΠ°Π»ΡŒΠ½ΠΎΠΉ части ΠΏΠ»Π΅Ρ‡Π΅Π²ΠΎΠΉ кости β€” это Ρ‚Ρ€Π°Π²ΠΌΠ°, которая составляСт Π΄ΠΎ 12 % ΠΎΡ‚ числа всСх ΠΏΠ΅Ρ€Π΅Π»ΠΎΠΌΠΎΠ² костСй скСлСта ΠΈ Π΄ΠΎ 65 % ΠΎΡ‚ ΠΏΠ΅Ρ€Π΅Π»ΠΎΠΌΠΎΠ² ΠΏΠ»Π΅Ρ‡Π΅Π²ΠΎΠΉ кости. ΠžΡ‚ 13 Π΄ΠΎ 16 % ΠΏΠ΅Ρ€Π΅Π»ΠΎΠΌΠΎΠ² Π² Π΄Π°Π½Π½ΠΎΠΌ сСгмСнтС ΠΈΠΌΠ΅ΡŽΡ‚ ΠΌΠ½ΠΎΠ³ΠΎΠΎΡΠΊΠΎΠ»ΡŒΡ‡Π°Ρ‚Ρ‹ΠΉ Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ с импрСссиСй костной Ρ‚ΠΊΠ°Π½ΠΈ, Ρ‡Ρ‚ΠΎ Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ услоТняСт Π·Π°Π΄Π°Ρ‡Ρƒ Π²Π½ΡƒΡ‚Ρ€Π΅Π½Π½Π΅ΠΉ фиксации. ЦСль Π΄Π°Π½Π½ΠΎΠ³ΠΎ исслСдования β€” ΠΏΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Π³Π΅Π½Π΄Π΅Ρ€Π½ΡƒΡŽ ΠΈ Π²ΠΎΠ·Ρ€Π°ΡΡ‚Π½ΡƒΡŽ структуру ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ΠΏΠ΅Ρ€Π΅Π»ΠΎΠΌΠ°ΠΌΠΈ ΠΏΡ€ΠΎΠΊΡΠΈΠΌΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΎΡ‚Π΄Π΅Π»Π° ΠΏΠ»Π΅Ρ‡Π΅Π²ΠΎΠΉ кости, Π° Ρ‚Π°ΠΊΠΆΠ΅ морфологичСскиС особСнности Π΄Π°Π½Π½Ρ‹Ρ… ΠΏΠΎΠ²Ρ€Π΅ΠΆΠ΄Π΅Π½ΠΈΠΉ.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ рСтроспСктивный Π°Π½Π°Π»ΠΈΠ· эпидСмиологичСских ΠΈ морфологичСских ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ² ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ², ΠΏΡ€ΠΎΠΎΠΏΠ΅Ρ€ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρƒ ΠΏΠΎΠ²Ρ€Π΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΏΡ€ΠΎΠΊΡΠΈΠΌΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΎΡ‚Π΄Π΅Π»Π° ΠΏΠ»Π΅Ρ‡Π΅Π²ΠΎΠΉ кости Π½Π° Π±Π°Π·Π΅ отдСлСния Ρ‚Ρ€Π°Π²ΠΌΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΎΡ€Ρ‚ΠΎΠΏΠ΅Π΄ΠΈΠΈ Π“Π‘Π£Π— Π Π‘ Π“Π‘ β„– 1 Π³. ΠžΠΊΡ‚ΡΠ±Ρ€ΡŒΡΠΊΠΈΠΉ Π·Π° ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ с ноября 2010 ΠΏΠΎ Π½ΠΎΡΠ±Ρ€ΡŒ 2016 Π³.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ обсуТдСниС. Π—Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ΅ ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ количСства ΠΏΠ΅Ρ€Π΅Π»ΠΎΠΌΠΎΠ² ΠΏΡ€ΠΎΠΊΡΠΈΠΌΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΎΡ‚Π΄Π΅Π»Π° ΠΏΠ»Π΅Ρ‡Π΅Π²ΠΎΠΉ кости (Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ Π² 3 Ρ€Π°Π·Π°) рСгистрируСтся Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½ Π² возрастной Π³Ρ€ΡƒΠΏΠΏΠ΅ 50–65 Π»Π΅Ρ‚, Ρƒ ΠΌΡƒΠΆΡ‡ΠΈΠ½ Π² возрастной ΠΊΠ°Ρ‚Π΅Π³ΠΎΡ€ΠΈΠΈ 55–60 Π»Π΅Ρ‚. Π£Π²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ количСства ΠΏΠΎΠ²Ρ€Π΅ΠΆΠ΄Π΅Π½ΠΈΠΉ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½, нСсомнСнно, обусловлСно ΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½ΠΎΠΏΠ°ΡƒΠ·Π°Π»ΡŒΠ½Ρ‹ΠΌΠΈ измСнСниями костного ΠΌΠ΅Ρ‚Π°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ°. Анализ Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π° ΠΈ морфологичСских особСнностСй ΠΏΠ΅Ρ€Π΅Π»ΠΎΠΌΠΎΠ² Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½ ΡΡ‚Π°Ρ€ΡˆΠΈΡ… возрастных Π³Ρ€ΡƒΠΏΠΏ ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΠ΅Ρ‚ ΠΎ большСй распространСнности Π½Π΅ΡΡ‚Π°Π±ΠΈΠ»ΡŒΠ½Ρ‹Ρ… ΠΏΠΎΠ²Ρ€Π΅ΠΆΠ΄Π΅Π½ΠΈΠΉ Ρ‚ΠΈΠΏΠ° 1.1.Π’ ΠΈ 1.1.Π‘ ΠΏΠΎ классификации АО/ASIF, Ρ‡Ρ‚ΠΎ ΠΎΠΏΡΡ‚ΡŒ-Ρ‚Π°ΠΊΠΈ обусловлСно Π΄Π΅ΠΌΠΈΠ½Π΅Ρ€Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠ΅ΠΉ сСгмСнта Π½Π° Ρ„ΠΎΠ½Π΅ ΡΠΎΠΏΡƒΡ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… ΠΎΠ±ΠΌΠ΅Π½Π½ΠΎ-мСтаболичСских Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΠΉ систСмного Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π°. ВыявлСнныС особСнности ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΡŽΡ‚ ΠΎ нСобходимости ΠΏΠ΅Ρ€ΠΈΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡ‚ΠΎΡ€ΠΈΠ½Π³Π° ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ² костного ΠΌΠ΅Ρ‚Π°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ°.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. ΠœΠΎΡ€Ρ„ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΈ Ρ‚ΠΈΠΏΡ‹ ΠΏΠ΅Ρ€Π΅Π»ΠΎΠΌΠΎΠ² зависят ΠΎΡ‚ возраста ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π° ΠΈ качСства кости. Π—Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ рост Π΄Π°Π½Π½ΠΎΠΉ ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠΈ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½ ΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½ΠΎΠΏΠ°ΡƒΠ·Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ возраста Π³ΠΎΠ²ΠΎΡ€ΠΈΡ‚ ΠΎΠ± измСнСниях ΠΌΠ΅Ρ‚Π°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Π² костях, вслСдствиС Ρ‡Π΅Π³ΠΎ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌ ΠΌΠΎΠ½ΠΈΡ‚ΠΎΡ€ΠΈΠ½Π³ костного ΠΌΠ΅Ρ‚Π°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Π² ΠΏΠ΅Ρ€ΠΈΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½Ρ‹ΠΉ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄

    Π Π°Π½Π½ΠΈΠ΅ измСнСния ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Ρ… ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ², ΡƒΠΌΠ΅Ρ€ΡˆΠΈΡ… ΠΎΡ‚ COVID-19

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    261,435,768 COVID-19 infections were detected worldwide, of them 5,207,634 deaths were registered. Identifying markers of the patient severity early in the course of the disease can facilitate the assessment of the risk of adverse outcome.The objective: To compare values of laboratory parameters and their changes during treatment of patients with a complicated course of COVID-19 infection.Subjects and Methods. 56 patients were included in the study, all of them were hospitalized to COVID Hospital of the Clinic of Bashkir State Medical University, Russian Ministry of Health, from September 30, 2021 to November 15, 2021, and their complicated course of the disease necessitated transfer to the intensive care unit (ICU). The laboratory evaluation included the following: a general blood and urine counts, blood chemistry including urea and creatinine, liver transaminases, and blood coagulogram (prothrombin time (PTT), prothrombin index (PTI), thrombin time, fibrinogen, and blood clotting time).Results. In the group of patients with a fatal outcome on the day of transfer to ICU, lymphocytopenia, eosinopenia, elevated values of creatinine, total bilirubin, transaminases, C-reactive protein, D-dimer, and ferritin were noted. Also on this day, microscopic hematuria, proteinuria and cylindruria were detected in the urine tests of most patients in this group during treatment.Conclusion. Critical deviations in the results of hematological and biochemical tests were revealed. Particular attention should be paid to such parameters as the level of erythrocytes, lymphocytes, eosinophils, glucose, urea, creatinine, total bilirubin, aspartate aminotransferase, alanine aminotransferase, creatine kinase, C-reactive protein, D-dimer, and ferritin.По Π΄Π°Π½Π½Ρ‹ΠΌ Π½Π° 01.12.2021 Π³., Π²ΠΎ всСм ΠΌΠΈΡ€Π΅ выявлСно 261 435 768 Π·Π°Π±ΠΎΠ»Π΅Π²ΡˆΠΈΡ… COVID-19, ΠΈΠ· ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… 5 207 634 ΡƒΠΌΠ΅Ρ€Π»ΠΈ. ВыявлСниС ΠΌΠ°Ρ€ΠΊΠ΅Ρ€ΠΎΠ² тяТСсти состояния ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² Π½Π° Ρ€Π°Π½Π½ΠΈΡ… сроках заболСвания ΠΌΠΎΠΆΠ΅Ρ‚ ΠΎΠ±Π»Π΅Π³Ρ‡ΠΈΡ‚ΡŒ ΠΎΡ†Π΅Π½ΠΊΡƒ риска нСблагоприятного исхода.ЦСль: ΡΡ€Π°Π²Π½ΠΈΡ‚ΡŒ значСния Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Ρ… ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ ΠΈ ΠΈΡ… Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡƒ Π² процСссС лСчСния ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ослоТнСнным Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ΠΌ COVID-19.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π» ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹: Π² исслСдовании приняли участиС 56 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ², госпитализированных Π² ΠΊΠΎΠ²ΠΈΠ΄-Π³ΠΎΡΠΏΠΈΡ‚Π°Π»ΡŒ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΈ Π€Π“Π‘ΠžΠ£ Π’Πž Β«Π‘Π“ΠœΠ£Β» ΠœΠΈΠ½Π·Π΄Ρ€Π°Π²Π° России с 30.09.2021 Π³. ΠΏΠΎ 15.11.2021 Π³., ослоТнСнноС Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ заболСвания ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… Π²Ρ‹Π·Π²Π°Π»ΠΎ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ ΠΏΠ΅Ρ€Π΅Π²ΠΎΠ΄Π° Π² ΠΎΡ‚Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Ρ€Π΅Π°Π½ΠΈΠΌΠ°Ρ†ΠΈΠΈ ΠΈ интСнсивной Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ (ОРИВ). ОбъСм Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½ΠΎΠ³ΠΎ обслСдования: ΠΎΠ±Ρ‰ΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΊΡ€ΠΎΠ²ΠΈ ΠΈ ΠΌΠΎΡ‡ΠΈ, биохимичСский Π°Π½Π°Π»ΠΈΠ· ΠΊΡ€ΠΎΠ²ΠΈ с ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ ΡƒΡ€ΠΎΠ²Π½Π΅ΠΉ ΠΌΠΎΡ‡Π΅Π²ΠΈΠ½Ρ‹ ΠΈ ΠΊΡ€Π΅Π°Ρ‚ΠΈΠ½ΠΈΠ½Π°, ΠΏΠ΅Ρ‡Π΅Π½ΠΎΡ‡Π½Ρ‹Ρ… трансаминаз, ΠΊΠΎΠ°Π³ΡƒΠ»ΠΎΠ³Ρ€Π°ΠΌΠΌΠ° ΠΊΡ€ΠΎΠ²ΠΈ (ΠΏΡ€ΠΎΡ‚Ρ€ΠΎΠΌΠ±ΠΈΠ½ΠΎΠ²ΠΎΠ΅ врСмя, ΠΏΡ€ΠΎΡ‚Ρ€ΠΎΠΌΠ±ΠΈΠ½ΠΎΠ²Ρ‹ΠΉ индСкс, Ρ‚Ρ€ΠΎΠΌΠ±ΠΈΠ½ΠΎΠ²ΠΎΠ΅ врСмя, Ρ„ΠΈΠ±Ρ€ΠΈΠ½ΠΎΠ³Π΅Π½, врСмя свСртывания ΠΊΡ€ΠΎΠ²ΠΈ).Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π»Π΅Ρ‚Π°Π»ΡŒΠ½Ρ‹ΠΌ исходом Π² дСнь ΠΏΠ΅Ρ€Π΅Π²ΠΎΠ΄Π° Π² ОРИВ ΠΎΡ‚ΠΌΠ΅Ρ‡Π΅Π½Ρ‹ лимфоцитопСния, эозинопСния, ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½Π½Ρ‹Π΅ значСния ΠΊΡ€Π΅Π°Ρ‚ΠΈΠ½ΠΈΠ½Π°, ΠΎΠ±Ρ‰Π΅Π³ΠΎ Π±ΠΈΠ»ΠΈΡ€ΡƒΠ±ΠΈΠ½Π°, трансаминаз, Π‘-Ρ€Π΅Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ°, D-Π΄ΠΈΠΌΠ΅Ρ€Π° ΠΈ Ρ„Π΅Ρ€Ρ€ΠΈΡ‚ΠΈΠ½Π°. Π’Π°ΠΊΠΆΠ΅ Π² этот дСнь Π² Π°Π½Π°Π»ΠΈΠ·Π°Ρ… ΠΌΠΎΡ‡ΠΈ Ρƒ Π±ΠΎΠ»ΡŒΡˆΠΈΠ½ΡΡ‚Π²Π° ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² Π΄Π°Π½Π½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΡ‹ Π² Ρ…ΠΎΠ΄Π΅ лСчСния Π±Ρ‹Π»ΠΈ ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Ρ‹ микроскопичСская гСматурия, протСинурия ΠΈ цилиндрурия.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. ВыявлСны критичСскиС отклонСния Π² Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°Ρ… гСматологичСских, биохимичСских Π°Π½Π°Π»ΠΈΠ·ΠΎΠ². ОсобоС Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π΄ΠΎΠ»ΠΆΠ½ΠΎ Π±Ρ‹Ρ‚ΡŒ ΡƒΠ΄Π΅Π»Π΅Π½ΠΎ Ρ‚Π°ΠΊΠΈΠΌ показатСлям, ΠΊΠ°ΠΊ ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ эритроцитов, Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ², эозинофилов, Π³Π»ΡŽΠΊΠΎΠ·Ρ‹, ΠΌΠΎΡ‡Π΅Π²ΠΈΠ½Ρ‹, ΠΊΡ€Π΅Π°Ρ‚ΠΈΠ½ΠΈΠ½Π°, ΠΎΠ±Ρ‰Π΅Π³ΠΎ Π±ΠΈΠ»ΠΈΡ€ΡƒΠ±ΠΈΠ½Π°, аспартатаминотрансфСразы, аланинаминотрансфСразы, ΠΊΡ€Π΅Π°Ρ‚ΠΈΠ½ΠΊΠΈΠ½Π°Π·Ρ‹, Π‘-Ρ€Π΅Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ°, D-Π΄ΠΈΠΌΠ΅Ρ€Π°, Ρ„Π΅Ρ€Ρ€ΠΈΡ‚ΠΈΠ½Π°
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