Melkersson-Rosenthal syndrome in a patient with Hashimoto disease

Introduction: Melkersson-Rosenthal syndrome (MRS) is a rare neurologic disease of unknown etiology. It is characterized by a triad of symptoms: relapsing peripheral facial paralysis; orofacial edema and fissured tongue. The pathological findings are varied but often characterized by the presence of noncaseating granuloma. There are few cases of MRS coexistent with Hashimoto disease in the literature. Purpose: To present a case of MRS coexistent with Hashimoto disease. Case presentation: We report a case of a 32-year-old woman with coexisting MRS and autoimmune thyroiditis, Hashimoto disease. Fissured tongue and recurrent cheilitis of the upper lip were observed. In her medical history, she had facial nerve palsy. Histopathological examination of the upper lips mucose membrane revealed the presence of granulomas confirming the diagnosis. Conclusions: Cooperation between clinicians and histopathologists is vital in diagnosing MRS. The presence of the anti-TPO antibodies in the case reported here could suggest a correlation between immunological alteration characteristics of autoimmune thyroiditis and MRS

Correlation of clinico-pathologic data with inflammatory cells infiltration in colorectal cancer

Introduction: Colorectal cancer (CRC) is the third most common cancer worldwide. At every phase of cancer development, the inflammatory process has an important impact. Accurate assessment inflammatory cells in the tumour environment in conjunction with clinico-pathologic features can be a relevant prognostic or predictive parameter. Purpose: To analyse inflammatory cell infiltration in CRC tumour mass and correlate with chosen clinico-pathologic parameters. Materials and methods: The study group consisted of 160 patients (64 women, 96 men) diagnosed with colorectal cancer who underwent surgery. Tissue material obtained from routine histopathological diagnosis was stained with H&E and used to assess the type of inflammatory cells in the invasive front and centre of the tumour. Results were subjected to statistical analysis with the age and gender of patients, tumour localization, tumour growth and size, TNM stage, adenocarcinoma type, fibrosis, necrosis, metastasis and tumour invasion (by the Spearman’s correlation coefficient test). Results: The presence of neutrophils in the invasive front of tumour mass was associated with fibrosis and inflammatory cell infiltration in the invasive front of tumour. Macrophages in the invasive front of tumour were found to correlate with tumour growth (expanding and infiltrate). Macrophages and eosinophils were associated with inflammatory cell infiltration in the invasive front and in the centre of tumour. Conclusions: The type of inflammatory cells in the invasive front or centre of the tumour may be useful to prognoses clinical features of colorectal cance