Biological Stoichiometry in Human Cancer

A growing tumor in the body can be considered a complex ecological and evolutionary system. A new eco-evolutionary hypothesis (the "Growth Rate Hypothesis", GRH) proposes that tumors have elevated phosphorus (P) demands due to increased allocation to P-rich nucleic acids, especially ribosomal RNA, to meet the protein synthesis demands of accelerated proliferation.We determined the elemental (C, N, P) and nucleic acid contents of paired malignant and normal tissues from colon, lung, liver, or kidney for 121 patients. Consistent with the GRH, lung and colon tumors were significantly higher (by approximately two-fold) in P content (fraction of dry weight) and RNA content and lower in nitrogen (N):P ratio than paired normal tissue, and P in RNA contributed a significantly larger fraction of total biomass P in malignant relative to normal tissues. Furthermore, patient-specific differences for %P between malignant and normal tissues were positively correlated with such differences for %RNA, both for the overall data and within three of the four organ sites. However, significant differences in %P and %RNA between malignant and normal tissues were not seen in liver and kidney and, overall, RNA contributed only approximately 11% of total tissue P content.Data for lung and colon tumors provide support for the GRH in human cancer. The two-fold amplification of P content in colon and lung tumors may set the stage for potential P-limitation of their proliferation, as such differences often do for rapidly growing biota in ecosystems. However, data for kidney and liver do not support the GRH. To account for these conflicting observations, we suggest that local environments in some organs select for neoplastic cells bearing mutations increasing cell division rate ("r-selected," as in colon and lung) while conditions elsewhere may select for reduced mortality rate ("K-selected," as in liver and kidney)

Clinical research evidence of cupping therapy in China: a systematic literature review

<p>Abstract</p> <p>Background</p> <p>Though cupping therapy has been used in China for thousands of years, there has been no systematic summary of clinical research on it.</p> <p>This review is to evaluate the therapeutic effect of cupping therapy using evidence-based approach based on all available clinical studies.</p> <p>Methods</p> <p>We included all clinical studies on cupping therapy for all kinds of diseases. We searched six electronic databases, all searches ended in December 2008. We extracted data on the type of cupping and type of diseases treated.</p> <p>Results</p> <p>550 clinical studies were identified published between 1959 and 2008, including 73 randomized controlled trials (RCTs), 22 clinical controlled trials, 373 case series, and 82 case reports. Number of RCTs obviously increased during past decades, but the quality of the RCTs was generally poor according to the risk of bias of the Cochrane standard for important outcome within each trials. The diseases in which cupping was commonly employed included pain conditions, herpes zoster, cough or asthma, etc. Wet cupping was used in majority studies, followed by retained cupping, moving cupping, medicinal cupping, etc. 38 studies used combination of two types of cupping therapies. No serious adverse effects were reported in the studies.</p> <p>Conclusions</p> <p>According to the above results, quality and quantity of RCTs on cupping therapy appears to be improved during the past 50 years in China, and majority of studies show potential benefit on pain conditions, herpes zoster and other diseases. However, further rigorous designed trials in relevant conditions are warranted to support their use in practice.</p

Study of the L-subshell X-ray production cross sections of Au by 20-50 MeV O5+ bombardments

在北京13 MV串列加速器上利用20—50MeV O5+离子研究Au的L壳层X射线产生截面. 实验结果表明σ（Ll）/σ（Lα） ，σ（Lβ）/σ（Lα） 和σ（Lγ）/σ（Lα）与EＣＰSSR理论计算结果符合比较好.在实验中由于较高的能量,在能量点存在能移现象.国家自然科学基金（批准号：10774149）资助的课题

Carbonate secondary porosity development in a polyphase paleokarst from Precambrian system: upper Sinian examples, North Tarim basin, northwest China

Carbonate karst is one of the research highlights in the field of carbonate reservoir geology. High porosity zones can develop in carbonate rocks which are modified by the karst. However, the carbonate porosity development and its evolution process in a polyphase paleokarst are rarely reported in the geological record. Here, the paper focuses on this point from the Precambrian Upper Sinian carbonate in the north Tarim basin, northwest China. Five outcrops and two wells reveal that the karstic porosity development of Upper Sinian carbonate was petrography-controlled of microbial dolostone and grain dolostone. The karstic porosities were in relation to three paleokarst phases: (1) eogenetic karst during depositional environment, (2) telogenetic karst at the end of late Sinian, and (3) hydrothermal karst in the early Permian. Eogenetic karst was related to frequent and short sea-level fluctuation, and was characterized by selective dissolution of intragranular dissolution porosity, moldic porosity, bird’s eye porosity, and intergranular dissolution porosity. Telogenetic karst was related to tectonic uplift, and was characteristic of non-selective dissolution of vugs and cavities with karst intensity increasing upward. Hydrothermal karst was related to geothermal events, and was featured by highly solution-enlarged porosities which mainly overprinted earlier telogenetic and eogenetic karst porosities. The suggested paleokarst model, combined with the related karstic porosity evolution process, will perfectly reveal its porosity development