Optimized Variables of the Study of Λb\Lambda_b Polarization

The value of the $b$-baryon polarization can be extracted from inclusive data at LEP with better than 10\% precision based on current statistics. We present a new variable by which to measure the polarization, which is the ratio of the average electron energy to the average neutrino energy. This variable is both sensitive to polarization and insensitive to fragmentation uncertainties.Comment: 10 pages (LaTeX), 2 figures, MIT-CTP-2270, CERN-PPE/94-0

Quantum Andreev Oscillations in normal-superconducting-normal nanostructures

We show that the voltage drop of specially prepared normal-superconducting-normal nanostructures show quantum Andreev oscillations as a function of magnetic field or input current. These oscillations are due to the interference of the electron wave function between the normal parts of the structure that act as reflective interfaces, i.e. our devices behave as a Fabry-Perot interferometer for conduction electrons. The observed oscillations and field periods are well explained by theory.Comment: 5 pages and 4 figure

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

IC80 1.5 to 34.5 nanograms per milliliter). We define the structural and functional determinants of binding for all four VOC-targeting antibodies and show that combinations of two antibodies decrease the in vitro generation of escape mutants, suggesting their potential in mitigating resistance development.The emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) that are resistant to therapeutic antibodies highlights the need for continuing discovery of broadly reactive antibodies. We identified four receptor binding domain-targeting antibodies from three early-outbreak convalescent donors with potent neutralizing activity against 23 variants, including the B.1.1.7, B.1.351, P.1, B.1.429, B.1.526, and B.1.617 VOCs. Two antibodies are ultrapotent, with subnanomolar neutralization titers [half-maximal inhibitory concentration (IC50) 0.3 to 11.1 nanograms per millilite