Dusty Universe viewed by AKARI far infrared detector

We present the results of the analysis of multiwavelength Spectral Energy Distributions (SEDs) of far-infrared galaxies detected in the AKARI Deep Field-South (ADF--S) Survey. The analysis uses a carefully selected sample of 186 sources detected at the 90 $\mu$m AKARI band, identified as galaxies with cross-identification in public catalogues. For sources without known spectroscopic redshifts, we estimate photometric redshifts after a test of two independent methods: one based on using mainly the optical -- mid infrared range, and one based on the whole range of ultraviolet -- far infrared data. We observe a vast improvement in the estimation of photometric redshifts when far infrared data are included, compared with an approach based mainly on the optical -- mid infrared range. We discuss the physical properties of our far-infrared-selected sample. We conclude that this sample consists mostly of rich in dust and young stars nearby galaxies, and, furthermore, that almost 25% of these sources are (Ultra)Luminous Infrared Galaxies. Average SEDs normalized at 90 $\mu$m for normal galaxies (138 sources), LIRGs (30 sources), and ULIRGs (18 galaxies) a the significant shift in the peak wavelength of the dust emission, and an increasing ratio between their bolometric and dust luminosities which varies from 0.39 to 0.73.Comment: 8 pages, 7 figures, published in Earth, Planets and Spac

The split between availability and selection. Business models for scientific information, and the scientific process?

The Berlin declaration on Open Access to Knowledge in the Sciences and Humanities has resulted in a strong impetus in the discussion on business models, and in particular the model of open access. A business model is defined as just the organisation of property. Consequently, business models for scientific information are discussed on the premise that any such business model should primarily produce added value for the scientific process next to commercial value for the research institution or intermediary acting as publisher. Furthermore, any business model should be sustainable. Scientific information is thus considered an integral part of the scientific process. It is not an end product but an intermediary product subject to scientific scrutiny. The final goal is to integrate the information into the scientific process. To this end, scientific information should be widely available for selection by the user as common property. Two basic business models emerge: one with the focus on added value as selection by the user known as the ‘subscription model’; and another one with the focus on wide availability known as the ‘open access’ model. Both in the subscription model as in the open access model it is the scientific community that invests. In the subscription model scientific information is more considered as external to the scientific process in a consumer type model, while in the open access model scientific information is more seen as internal, as necessary acquisition costs for the scientific process. In the subscription model there is less incentive for broad availability of information whereas in the open access model there is less incentive to develop and maintain added value services to facilitate the selection by the reader. The organisation of property is a condition sine qua non. Although common property, the information is owned by the author claiming this property by the act of publication. Core to this claim of property is peer review being therefore core to any business model. The author is interested in protecting his moral rights against plagiarism; the publisher is interested in protecting the added value against commercial abuse. It is suggested that open access repositories could boost if repository management would guarantee protection of the moral rights of the author. In this way, the protection to the two main infringements could be split over different stakeholders. This would also allow separating the responsibility for availability coupled with peer review as a basic service from added value services coupled to selection at an optional charge. In the end, any business model has to fulfill the basic idea that scientific information is not there just for the record as a commodity, but is there to be used in research and teaching: scientific information has no value in itself

Knowledge transfer activities of scientists in nanotechnology

In this paper, we present a theory of strategic positioning that explains scientists’ strategic behavior in knowledge transfer from university to industry. The theory is based on the drivers strategic interdependence and organizational autonomy and entails three modes of behavior of scientists: mode1, mode2, and mode3 (the research entrepreneur). The results of an empirical study conducted at a research institute for nanotechnology show that, to increase the likelihood of scientists engaging in knowledge transfer to industry, scientists need to have a high need for autonomy (expressed in decision-making on collaboration with industry and join research projects) and a high need for interdependence (expressed in the need for resources such as knowledge, skills, facilities, etc.). Scientists’ academic and industry orientations do not change the effect of the strategic positioning theory on the likelihood of engagement with industry, nor the likelihood of knowledge transfer. The strategic positioning theory explains 43 % of the variance, i.e. there is a firm foundation for managerial practices for different scientist modes of strategic behavior

Impact of European Integration on the Functioning of the Insurance Market in Poland

The transformation process, that has begun 20 years ago, generated significant changes in the structure and organization of Polish economy. It stimulated development of particular market's segments, especially of the insurance sector. Poland's accession to the European Union required conformity to Its regulations, fulfillment of several conditions connected with the membership in the European Community. The purpose of this article is to present the main consequences of Poland's integration with EU in the field of insurance market. Joining the common market was an important challenge for this sector in our country.Rok 1990 stanowił początek procesu transformacji systemu społeczno - gospodarczego i ustrojowego. Ostatnie 20 lat to okres intensywnych przemian o charakterze strukturalnym i organizacyjnym, w wyniku których ukształtowały się warunki rozwoju poszczególnych segmentów systemu finansowego państwa, zwłaszcza sektora ubezpieczeń. Przystąpienie Polski do Unii Europejskiej wymagało wprowadzenia szeregu zmian, dostosowujących polski porządek prawny do uregulowań wspólnotowych regulujących funkcjonowanie rynku ubezpieczeń. Celem artykułu jest zaprezentowanie szans i zagrożeń, jakie wynikają dla tego segmentu gospodarki z przystąpienia Polski do UE. Niewątpliwie proces integracji stanowił poważne wyzwanie dla polskiego rynku ubezpieczeń

Direct on-chip differentiation of intestinal tubules from induced pluripotent stem cells

Intestinal organoids have emerged as the new paradigm for modelling the healthy and diseased intestine with patient-relevant properties. In this study, we show directed differentiation of induced pluripotent stem cells towards intestinal-like phenotype within a microfluidic device. iPSCs are cultured against a gel in microfluidic chips of the OrganoPlate, in which they undergo stepwise differentiation. Cells form a tubular structure, lose their stem cell markers and start expressing mature intestinal markers, including markers for Paneth cells, enterocytes and neuroendocrine cells. Tubes develop barrier properties as confirmed by transepithelial electrical resistance (TEER). Lastly, we show that tubules respond to pro-inflammatory cytokine triggers. The whole procedure for differentiation lasts 14 days, making it an efficient process to make patient-specific organoid tubules. We anticipate the usage of the platform for disease modelling and drug candidate screening

Compensatory Puffing With Lower Nicotine Concentration E-liquids Increases Carbonyl Exposure in E-cigarette Aerosols

Introduction: Article 20 of the European Tobacco Products Directive (EU-TPD) specifies that e-liquids should not contain nicotine in excess of 20 mg/mL, thus many vapers may be compelled to switch to lower concentrations and in so doing, may engage in more intensive puffing. This study aimed to establish whether more intensive puffing produces higher levels of carbonyl compounds in e-cigarette aerosols. Methods: Using the HPLC-UV diode array method, four carbonyl compounds (formaldehyde, acetaldehyde, acetone, and acrolein) were measured in liquids and aerosols from nicotine solutions of 24 and 6 mg/mL. Aerosols were generated using a smoking machine configured to replicate puffing topography data previously obtained from 12 experienced e-cigarette users. Results: Carbonyl levels in aerosols from the puffing regimen of 6 mg/mL were significantly higher (p < .05 using independent samples t tests) compared with those of 24 mg/mL nicotine. For the 6 and 24 mg/mL nicotine aerosols respectively, means ± SD for formaldehyde levels were 3.41 ± 0.94, and 1.49 ± 0.30 μg per hour (μg/h) of e-cigarette use. Means ± SD for acetaldehyde levels were 2.17 ± 0.36 and 1.04 ± 0.13 μg/h. Means ± SD for acetone levels were 0.73 ± 0.20 and 0.28 ± 0.14 μg/h. Acrolein was not detected. Conclusions: Higher levels of carbonyls associated with more intensive puffing suggest that vapers switching to lower nicotine concentrations (either due to the EU-TPD implementation or personal choice), may increase their exposure to these compounds. Based on real human puffing topography data, this study suggests that limiting nicotine concentrations to 20 mg/mL may not result in the desired harm minimalization effect. Implications: More intensive puffing regimens associated with the use of low nicotine concentration e-liquids can lead to higher levels of carbonyl generation in the aerosol. Although in need of replication in a larger sample outside a laboratory, this study provides pragmatic empirical data on the potential risks of compensatory puffing behaviors in vapers, and can help to inform future regulatory decisions on nicotine e-liquid concentrations. The cap on nicotine concentration at 20 mg/mL set by the EU-TPD may therefore have the unintended consequence of encouraging use of lower nicotine concentration e-liquid, in turn increasing exposure to carbonyl compounds through compensatory puffing