10 research outputs found
Diffuse Intracystic Papillary Neoplasm Indistinguishable from Gallbladder Cancer: A Case Report
Development of a Multifunctional Lightweight Membrane with a High Specific Power Generation Capacity
As a lighter power generation system, Japan Aerospace Exploration Agency (JAXA) and Sakase Adtech Corp. are developing a demonstrator component named “Harvesting Energy with Lightweight Integrated Origami Structure” (HELIOS), which is a deployable lightweight membrane structure. HELIOS has solar arrays on its surface and demonstrates the technology which enables higher specific power generation capacity compared to the conventional solar array panels. The membrane also has communication antennas, showing the potency of lightweight membrane’s multifunctionality such as large data transmitting by 5G antennas and high-resolution observation by interferometer antennas. This paper presents the component’s concept and design, and the expected achievements
Feasibility study of motion pre-analysis method for whole-heart magnetic resonance coronary angiography (WH MRCA)
Feasibility study of Global-to-Local Tandem Method for detecting the coronary stationary period in whole-heart magnetic resonance coronary angiography (WH MRCA)
Feasibility study of motion pre-analysis method for whole-heart magnetic resonance coronary angiography (WH MRCA)
Journal of Cardiovascular Magnetic Resonance BioMed Central Poster presentation
Feasibility study of motion pre-analysis method for wholeheart magnetic resonance coronary angiography (WH MRCA
Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging
Abstract Chronic obstructive pulmonary disease (COPD) has been recently characterized as a disease of accelerated lung aging, but the mechanism remains unclear. Tetraspanins have emerged as key players in malignancy and inflammatory diseases. Here, we found that CD9/CD81 double knockout (DKO) mice with a COPD-like phenotype progressively developed a syndrome resembling human aging, including cataracts, hair loss, and atrophy of various organs, including thymus, muscle, and testis, resulting in shorter survival than wild-type (WT) mice. Consistent with this, DNA microarray analysis of DKO mouse lungs revealed differential expression of genes involved in cell death, inflammation, and the sirtuin-1 (SIRT1) pathway. Accordingly, expression of SIRT1 was reduced in DKO mouse lungs. Importantly, siRNA knockdown of CD9 and CD81 in lung epithelial cells additively decreased SIRT1 and Foxo3a expression, but reciprocally upregulated the expression of p21 and p53, leading to reduced cell proliferation and elevated apoptosis. Furthermore, deletion of these tetraspanins increased the expression of pro-inflammatory genes and IL-8. Hence, CD9 and CD81 might coordinately prevent senescence and inflammation, partly by maintaining SIRT1 expression. Altogether, CD9/CD81 DKO mice represent a novel model for both COPD and accelerated senescence