Equine body weight estimation using three-dimensional images

Includes bibliographical references.2015 Summer.Accurately estimating the body weight (BW) of a horse is important in order to make appropriate management and treatment decisions. Most field equine veterinarians and experienced equine people, however, visually estimate BW because large animal scales are impractical for field use due to the weight (>80 kg), size (length >200 cm), and cost (>$1,000). There are some alternative BW estimation methods such as a weight tape or BW estimation using a combination of heart girth and body length measurements. These methods, however, have 5 - 15% or even higher margin of error. According to human studies, there is a high correlation between BW and body volume (BV). Correlation coefficient (R) between these two variables is 0.996-0.998. Our study was designed to develop methods to estimate the BW of horses by using 3D image based BV measurement. 3D imaging technology allows easy and accurate measurement of diverse indices of an object, including the volume. Recent development of Structure-light 3D scanning technology allows 3D scanning of an object as large as 3 by 3 square meter in a short time. In this study, 3D images of 22 and 11 horses were obtained by using 3D scanning (3DScan) and photogrammetry (2Dto3D), respectively. BV and trunk volume (TV) of the horses were measured from the obtained 3D images. Measurements of BW using five conventional methods (visual estimation, 2 weight tapes (Purina, Shell), estimated BW by using heart girth and body length (Carroll’s formula), and a large animal scale) were also conducted, and the data of body condition score (BCS), sex, coat color, and coat type of the horses were collected. Linear regression models to estimate the BW of the horse based on the volume and other independent variables were developed using regression model stepwise selection procedures (P<0.05). Variables selected in 3DScan method were BV, sex, and coat type, and, in 2Dto3D method, BV (TV) was selected. The coefficient of determination of the developed regression models were 0.95 and 0.78-0.82, respectively, and the average percent errors of the predicted BW compared to the true BW of horses were 2.07 % and 2.67 %, respectively. The accuracy of the 3DScan method was significantly more accurate than WT, Carroll’s formual, and VE (P<0.05). 3D image based BW measurement method had higher accuracy and convenience compared to conventional alternative BW measuring methods. Accurate and easy determination of BW using 3D images will allow for regular BW measurement in the field and allow optimal equine health management by equine stakeholders and practitioners. The 3D images obtained in this study were highly detailed. Further graphical analysis of the obtained 3D images will make it possible to use this technology on automatic evaluation of body condition score, equine conformation evaluation, breed registration, and the study of pharmacokinetics and dynamics of newly developed drugs. This research findings may also have utility for application to wild or zoo animals such as the elephant, rhinoceros, or even the tiger where hands on collection of body weight would be challenging

RankBooster: Visual analysis of ranking predictions

Ranking is a natural and ubiquitous way to facilitate decision-making in various applications. However, different rankings are often used for the same set of entities, with each ranking method placing emphasis on different factors. These factors can also be multi-dimensional in nature, compounding the problem. This complexity can make it challenging for an entity which is being ranked to understand what they can do to improve their rankings, and to analyze the effect of changes in various factors to their overall rank. In this paper, we present RankBooster, a novel visual analytics system to help users conveniently investigate ranking predictions. We take university rankings as an example and focus on helping universities to better explore their rankings, where they can compare themselves to their rivals in key areas as well as overall. Novel visualizations are proposed to enable efficient analysis of rankings, including a Scenario Analysis View to show a high-level summary of different ranking scenarios, a Relationship View to visualize the influence of each attribute on different indicators and a Rival View to compare the ranking of a university and those of its rivals. A case study demonstrates the usefulness and effectiveness of RankBooster in facilitating the visual analysis of ranking predictions and helping users better understand their current situation.Comment: 4 Pages, Accepted as a short paper for EuroVis 202

Concurrent Multilocular Cystic Renal Cell Carcinoma and Leiomyoma in the Same Kidney: Previously Unreported Association

We present an unusual case of concurrent occurrence of a multilocular cystic renal cell carcinoma and a leiomyoma in the same kidney of a patient with no evident clinical symptoms. A 38-year-old man was found incidentally to have a cystic right renal mass on computed tomography. Laparoscopic radical nephrectomy was performed under a preoperative diagnosis of cystic renal cell carcinoma. Histology revealed a multilocular cystic renal cell carcinoma and a leiomyoma. This is the first report of this kind of presentation

Red Ginseng Extract Facilitates the Early Differentiation of Human Embryonic Stem Cells into Mesendoderm Lineage

Human embryonic stem cells (hESCs) have capacities to self-renew and differentiate into all cell types in vitro. Red ginseng (RG) is known to have a wide range of pharmacological effects in vivo; however, the reports on its effects on hESCs are few. In this paper, we tried to demonstrate the effects of RG on the proliferation and differentiation of hESCs. Undifferentiated hESCs, embryoid bodies (EBs), and hESC-derived cardiac progenitors (CPs) were treated with RG extract at 0.125, 0.25, and 0.5 mg/mL. After treatment of undifferentiated hESCs from day 2 to day 6 of culture, BrdU labeling showed that RG treatment increased the proliferation of hESCs, and the expression of Oct4 and Nanog was increased in RG-treated group. To find out the effects of RG on early differentiation stage cells, EBs were treated with RG extract for 10 days and attached for further differentiation. Immunostaining for three germ layer markers showed that RG treatment increased the expressions of Brachyury and HNF3β on EBs. Also, RG treatment increased the expression of Brachyury in early-stage and of Nkx2.5 in late-stage hESC-derived CPs. These results demonstrate facilitating effects of RG extract on the proliferation and early differentiation of hESC

Phylogenetic analysis and characterization of Korean orf virus from dairy goats: case report

An outbreak of orf virus infection in dairy goats in Korea was investigated. Suspected samples of the skin and lip of affected goats were sent to the laboratory for more exact diagnosis. Orf virus was detected by electron microscopy and viral DNA was identified by PCR. To reveal the genetic characteristics of the Korean strain (ORF/09/Korea), the sequences of the major envelope protein (B2L) and orf virus interferon resistance (VIR) genes were determined and then compared with published reference sequences. Phylogenetic analysis revealed that the ORF/09/Korea strain was closest to the isolates (Taiping) from Taiwan. This is believed to be the first report on the molecular characterization of orf virus in Korea

Crystal structure of peroxiredoxin 3 from Vibrio vulnificus

Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidase enzymes. Recently, a new type of Prx, VvPrx3, was identified in the pathogenic bacterium Vibrio vulnificus as being important for survival in macrophages. It employs only one catalytic cysteine residue to decompose peroxides. Here, crystal structures of VvPrx3 representing its reduced and oxidized states have been determined, together with an H2O2-bound structure, at high resolution. The crystal structure representing the reduced Prx3 showed a typical dimeric interface, called the A-type interface. However, VvPrx3 forms an oligomeric interface mediated by a disulfide bond between two catalytic cysteine residues from two adjacent dimers, which differs from the doughnut-like oligomers that appear in most Prxs. Subsequent biochemical studies showed that this disulfide bond was induced by treatment with nitric oxide (NO) as well as with peroxides. Consistently, NO treatment induced expression of the prx3 gene in V. vulnificus, and VvPrx3 was crucial for the survival of bacteria in the presence of NO. Taken together, the function and mechanism of VvPrx3 in scavenging peroxides and NO stress via oligomerization are proposed. These findings contribute to the understanding of the diverse functions of Prxs during pathogenic processes at the molecular level

Incidence of Endocrine-Related Dysfunction in Patients Treated with New Immune Checkpoint Inhibitors: A Meta-Analysis and Comprehensive Review

Background This study investigated the incidence of endocrine immune-related adverse events (irAEs) for recently developed immune checkpoint inhibitor (ICI) drugs. Methods We collected studies on newly developed ICI drugs using PubMed/Medline, Embase, and Cochrane Library from inception through January 31, 2023. Among ICI drugs, nivolumab, pembrolizumab, and ipilimumab were excluded from the new ICI drugs because many papers on endocrine-related side effects have already been published. Results A total of 44,595 patients from 177 studies were included in this analysis. The incidence of hypothyroidism was 10.1% (95% confidence interval [CI], 8.9% to 11.4%), thyrotoxicosis was 4.6% (95% CI, 3.8% to 5.7%), hypophysitis was 0.8% (95% CI, 0.5% to 1.1%), adrenal insufficiency was 0.9% (95% CI, 0.7% to 1.1%), and hyperglycemia was 2.3% (95% CI, 1.6% to 3.4%). Hypothyroidism and thyrotoxicosis occurred most frequently with programmed cell death protein-1 (PD-1) inhibitors (13.7% and 7.5%, respectively). The rate of endocrine side effects for the combination of a programmed death-ligand 1 inhibitor (durvalumab) and cytotoxic T lymphocyte-associated antigen 4 inhibitor (tremelimumab) was higher than that of monotherapy. In a meta-analysis, the combination of tremelimumab and durvalumab had a 9- to 10-fold higher risk of pituitary and adrenal-related side effects than durvalumab alone. Conclusion Newly developed PD-1 inhibitors had a high incidence of thyroid-related irAEs, and combined treatment with durvalumab and tremelimumab increased the risk of pituitary- and adrenal-related irAEs. Based on these facts, it is necessary to predict the endocrine side effects corresponding to each ICI drug, diagnose and treat them appropriately, and try to reduce the morbidity and mortality of patients