Studies on Copper and Aβ1-16-Induced Conformational Changes in CAG/CTG Trinucleotide Repeats Sequence

DNA conformation and stability are critical for the normal cell functions, which control many cellular processes in life, such as replication, transcription, DNA repair, etc. The accumulation of amyloid-β peptide (Aβ) and Copper (Cu) are the etiological factors for neurodegenerative diseases and hypothesized that they can cause DNA instability. In the current investigation, we studied copper and Aβ1-16 induced conformation and stability changes in CAG/CTG sequences and found alterations from B-DNA to altered B-conformation. Further, the interaction of the copper and Aβ1-16 with CAG/CTG sequences was studied by molecular docking modeling and results indicated that the interaction of copper and Aβ1-16 was through the hydrogen bond formation between adenine, guanine, and cytocine. This study illustrates the role of the copper and Aβ1-16 in modulating the DNA conformation and stability.DNA conformation and stability are critical for the normal cell functions, which control many cellular processes in life, such as replication, transcription, DNA repair, etc. The accumulation of amyloid-β peptide (Aβ) and Copper (Cu) are the etiological factors for neurodegenerative diseases and hypothesized that they can cause DNA instability. In the current investigation, we studied copper and Aβ1-16 induced conformation and stability changes in CAG/CTG sequences and found alterations from B-DNA to altered B-conformation. Further, the interaction of the copper and Aβ1-16 with CAG/CTG sequences was studied by molecular docking modeling and results indicated that the interaction of copper and Aβ1-16 was through the hydrogen bond formation between adenine, guanine, and cytocine. This study illustrates the role of the copper and Aβ1-16 in modulating the DNA conformation and stability

XIX sajand – murranguaeg eesti folklooris ja alusterajaja folkloristikas

The article discusses the 19th century as the period of great changes in Estonian folklore, which laid a foundation for folkloristics. The 19th century was characterised by the quick receding and even fading of folk culture; on the other hand, prerequisites emerged for extensive collecting of folklore and establishing foundations for national culture