57 research outputs found
Electronic Structures of Porous Nanocarbons
We use large scale ab-initio calculations to describe electronic structures
of graphene, graphene nanoribbons, and carbon nanotubes periodically perforated
with nanopores. We disclose common features of these systems and develop a
unified picture that permits us to analytically predict and systematically
characterize metal-semiconductor transitions in nanocarbons with superlattices
of nanopores of different sizes and types. These novel materials with highly
tunable band structures have numerous potential applications in electronics,
light detection, and molecular sensing.Comment: 7 pages, 8 figure
A Conserved Role for SNX9-Family Members in the Regulation of Phagosome Maturation during Engulfment of Apoptotic Cells
Clearance of apoptotic cells is of key importance during development, tissue homeostasis and wound healing in multi-cellular animals. Genetic studies in the nematode Caenorhabditis elegans have identified a set of genes involved in the early steps of cell clearance, in particular the recognition and internalization of apoptotic cells. A pathway that orchestrates the maturation of phagosomes containing ingested apoptotic cells in the worm has recently been described. However, many steps in this pathway remain elusive. Here we show that the C. elegans SNX9-family member LST-4 (lateral signaling target) and its closest mammalian orthologue SNX33 play an evolutionary conserved role during apoptotic cell corpse clearance. In lst-4 deficient worms, internalized apoptotic cells accumulated within non-acidified, DYN-1-positive but RAB-5-negative phagosomes. Genetically, we show that LST-4 functions at the same step as DYN-1 during corpse removal, upstream of the GTPase RAB-5. We further show that mammalian SNX33 rescue C. elegans lst-4 mutants and that overexpression of truncated SNX33 fragments interfered with phagosome maturation in a mammalian cell system. Taken together, our genetic and cell biological analyses suggest that LST-4 is recruited through a combined activity of DYN-1 and VPS-34 to the early phagosome membrane, where it cooperates with DYN-1 to promote recruitment/retention of RAB-5 on the early phagosomal membrane during cell corpse clearance. The functional conservation between LST-4 and SNX33 indicate that these early steps of apoptotic phagosome maturation are likely conserved through evolution
Quantification of left ventricular functional parameter values using 3D spiral bSSFP and through-time Non-Cartesian GRAPPA
Synthesis of submicron sized silver powder for metal deposition via laser sintered inkjet printing
Electrical Property and Surface Morphology of Silver Nanoparticles After Thermal Sintering
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