Response to sunitinib (Sutent) in chemotherapy refractory clear cell ovarian cancer

• Case describes a response to sunitinib in clear cell ovarian cancer. • Discussion of unique molecular characteristics of clear cell ovarian cancers; • Practical points regarding dosing and toxicity when using sunitinib discussed

Fluorogenic and bioorthogonal modification of rna using photoclick chemistry

A bromoaryltetrazole-modified uridine was synthesized as a new RNA building block for bioorthogonal, light-activated and postsynthetic modification with commercially available fluorescent dyes. It allows “photoclick”-type modifications by irradiation with light (300 nm LED) at internal and terminal positions of presynthesized RNA with maleimide-conjugated fluorophores in good yields. The reaction was evidenced for three different dyes. During irradiation, the emission increases due to the formation of an intrinsically fluorescent pyrazoline moiety as photoclick product. The fluorogenecity of the photoclick reaction was significantly enhanced by energy transfer between the pyrazoline as the reaction product (poor emitter) and the photoclicked dye as the strong emitter. The RNA-dye conjugates show remarkable fluorescent properties, in particular an up to 9.4 fold increase of fluorescence, which are important for chemical biology and fluorescent imaging of RNA in cells

Studies on new antifreeze protein from the psychrophilic diatom, Fragilariopsis cylindrus

Antifreeze proteins (AFPs) are found in a wide range of species including fishes, plants, etc. They have very characteristic feature that inhibit the growth and recrystallization of ice that forms in intercellular spaces. Two expressed sequence tags (ESTs) were previously identified from salt stress cDNA library in Fragilariopsis cylindrus to have similarities with snow mold AFP. Using bioinformatics tools, we analysed these two AFP-ESTs. Accordingly, by using specially designed primers, the open reading frames (ORFs) subcloned into bacterial and plant expression vectors. The predicted gene product, AfpA, had a molecular mass of 27 kDa. Expression of afpA in Escherichia coli yielded an intracellular 27-kDa protein modified with His-tag. According to bioinformatics data, a comparison between AFP-A and carrot AFP has been carried out.Key words: Antifreeze protein, Fragilariopsis cylindrus, recrystallization inhibition

Modellkosten in der Weichkäserei

Die Serie von Modellabteilungsrechnungen wird mit der Untersuchung des Kostenverlaufs in der Abteilung Weichkäse fortgefuhrt, um einen weiteren Baustein zur Bestimmung optimaler Produktionsstrukturen zu erhalten. Als Ausgangsposition dieser Themenstellung soll im folgenden die Modellabteilung Weichkäse Gestalt annehmen. Dazu sind drei Arbeitsschritte notwendig: die Festlegung des zu untersuchenden Produktes, die inhaltliche Abgrenzung der zu bildenden Modellabteilung und die Auswahl des Fertigungsverfahrens

Perceptions of Illegitimate Power in IT Projects

When IT projects are initiated because of personal benefits then the initiator acts contrary the legitimate power of their organisational position. Due to their expertise and technical knowledge, IT managers may believe that during the initiation of an IT project power boundaries were crossed and hence, develop perceptions of power misuse, or as termed in the literature, perceptions of illegitimate power. Building on existing work in the area of organisational power and resistance, we examine the extent to which four factors (IT project complexity, IT project benefit creation ability, top management commitment, and formal project management) influence an IT manager’s perceptions of illegitimate power in IT projects. Our empirical analysis confirmed that three of four factors affect perceptions of illegitimate power; only the hypothesis between formal project management and perceived illegitimate power was not significant. This paper contributes to IS research because it is an initial attempt to capture factors that trigger perceived illegitimate power. The research has practical implications because it demonstrates how illegitimate power perceptions emerge

Early-season management of bean leaf beetle and bean pod mottle virus

During the past three summers, bean leaf beetles have reached historically high populations. At the same time, we learned that the insects are transmitting a disease called bean pod mottle virus. The occurrence of both of these pests in Iowa soybean has dramatically affected yields. Because the beetles are spreading the virus in soybean, we must rethink how we are going to manage these two pests

Investigating the benefits of molecular profiling of advanced non-small cell lung cancer tumors to guide treatments.

In this study we utilized data on patient responses to guided treatments, and we evaluated their benefit for a non-small cell lung cancer cohort. The recommended therapies used were predicted using tumor molecular profiles that involved a range of biomarkers but primarily used immunohistochemistry markers. A dataset describing 91 lung non-small cell lung cancer patients was retrospectively split into two. The first group's drugs were consistent with a treatment plan whereby all drugs received agreed with their tumor's molecular profile. The second group each received one or more drug that was expected to lack benefit. We found that there was no significant difference in overall survival or mortality between the two groups. Patients whose treatments were predicted to be of benefit survived for an average of 402 days, compared to 382 days for those that did not (P = 0.7934). In the matched treatment group, 48% of patients were deceased by the time monitoring had finished compared to 53% in the unmatched group (P = 0.6094). The immunohistochemistry biomarker for the ERCC1 receptor was found to be a marker that could be used to predict future survival; ERCC1 loss was found to be predictive of poor survival

Residencia universitaria en la Universidad de Lausana, Suiza

This university residence consists, basically, of two main blocks. One contains the bedrooms, and operates in a manner that is similar to that of a hotel. The other is occupied by the hexagonally shaped restaurant, and its lower height provides a pleasant contrast to the total design. Both blocks are linked by a platform that serves as roof for the commercial zone, the offices and the laboratories. The residence has 150 bedrooms, 3 apartments, a restaurant, a cafeteria, a music room, a reading room and the usual services. The external and internal aspect is satisfying and correct, very simple, and is expressed in long lasting textures that are easy to maintain.Esta residencia universitaria consta, esencialmente, de dos cuerpos de edificio: uno aloja las habitaciones y funciona con régimen similar al de un hotel; y otro, ocupado por un restaurante con planta hexagonal, cuyo volumen más bajo aporta una nota graciosa al conjunto. Ambos cuerpos están unidos por una plataforma que sirve de techo a los locales comerciales, despachos y laboratorios creados. La residencia comprende: 150 habitaciones, 3 apartamentos, un restaurante y una cafetería, sala de música, sala de lectura, etc., y los servicios generales correspondientes. Sus tratamientos exterior e interior son correctos, de elegante sencillez, textura duradera y de fácil entretenimiento

The Time He Loves The Best

Photo of woman and babyhttps://scholarsjunction.msstate.edu/cht-sheet-music/1536/thumbnail.jp