Cryptic female choice favours sperm from major histocompatibility complex-dissimilar males

Cryptic female choice may enable polyandrous females to avoid inbreeding or bias offspring variability at key loci after mating. However, the role of these genetic benefits in cryptic female choice remains poorly understood. Female red junglefowl, Gallus gallus, bias sperm use in favour of unrelated males. Here, we experimentally investigate whether this bias is driven by relatedness per se, or by similarity at the major histocompatibility complex (MHC), genes central to vertebrate acquired immunity, where polymorphism is critical to an individual's ability to combat pathogens. Through experimentally controlled natural matings, we confirm that selection against related males' sperm occurs within the female reproductive tract but demonstrate that this is more accurately predicted by MHC similarity: controlling for relatedness per se, more sperm reached the eggs when partners were MHC-dissimilar. Importantly, this effect appeared largely owing to similarity at a single MHC locus (class I minor). Further, the effect of MHC similarity was lost following artificial insemination, suggesting that male phenotypic cues might be required for females to select sperm differentially. These results indicate that postmating mechanisms that reduce inbreeding may do so as a consequence of more specific strategies of cryptic female choice promoting MHC diversity in offspring

Challenges for funders in monitoring compliance with policies on clinical trials registration and reporting: analysis of funding and registry data in the UK

Objectives: To evaluate compliance by researchers with funder requirements on clinical trial transparency, including identifying key areas for improvement; to assess the completeness, accuracy and suitability for annual compliance monitoring of the data routinely collected by a research funding body. / Design: Descriptive analysis of clinical trials funded between February 2011 and January 2017 against funder policy requirements. / Setting: Public medical research funding body in the UK. / Data sources: Relevant clinical trials were identified from grant application details, post-award grant monitoring systems and the International Standard Randomised Controlled Trial Number (ISRCTN) registry. / Main outcome measure: The proportion of all Medical Research Council (MRC)-funded clinical trials that were (a) registered in a clinical trial registry and (b) publicly reported summary results within 2 years of completion. / Results: There were 175 grants awarded that included a clinical trial and all trials were registered in a public trials registry. Of 62 trials completed for over 24 months, 42 (68%) had publicly reported the main findings by 24 months after trial completion; 18 of these achieved this within 12 months of completion. 11 (18%) trials took >24 months to report and 9 (15%) completed trials had not yet reported findings. Five datasets were shared with other researchers. / Conclusions: Compliance with the funder policy requirements on trial registration was excellent. Reporting of the main findings was achieved for most trials within 24 months of completion; however, the number of unreported trials remains a concern and should be a focus for future funder policy initiatives. Identifying trials from grant management and grant monitoring systems was challenging therefore funders should ensure investigators reliably provide trial registries with information and regularly update entries with details of trial publications and protocols

Signatures of Coronal Heating Mechanisms

Alfven waves created by sub-photospheric motions or by magnetic reconnection in the low solar atmosphere seem good candidates for coronal heating. However, the corona is also likely to be heated more directly by magnetic reconnection, with dissipation taking place in current sheets. Distinguishing observationally between these two heating mechanisms is an extremely difficult task. We perform 1.5-dimensional MHD simulations of a coronal loop subject to each type of heating and derive observational quantities that may allow these to be differentiated.Comment: To appear in "Magnetic Coupling between the Interior and the Atmosphere of the Sun", eds. S.S. Hasan and R.J. Rutten, Astrophysics and Space Science Proceedings, Springer-Verlag, Heidelberg, Berlin, 200

Assembling a global health image: ethical and pragmatic tensions through the lenses of photographers

Background: Recently, global health has been confronting its visual culture, historically modulated by colonialism, racism and abusive representation. There have been international calls to promote ethicality of visual practices. However, despite this focus on the history and the institutional use of global health images, little is known about how in practice contemporary images are created in communities, and how consent to be in photographs is obtained. Methods: We conducted semi-structured interviews with 29 global health photographers about the ethical and practical challenges they experience in creating global health images, and thematically analysed the findings. Findings: The following themes were identified: (1) global health photography is undergoing a marketing transformation and images are being increasingly moderated; (2) photographers routinely negotiate stereotypical and abusive tropes purposefully sought by organisations; (3) local scenes are modified, enhanced and staged to achieve a desired marketing effect; (4) ‘empowerment’ is becoming an increasingly prominent dehumanising visual trope; (5) consent to be photographed can be jeopardised by power imbalances, illiteracy, fears and trust; (6) organisations sometimes problematically recycle images. Interpretation/Discussion: This research has identified practical and ethical issues experienced by global health photographers, suggesting that the production cycle of global health images can be easily abused. The detected themes raise questions of responsibility and accountability, and require further transdisciplinary discussion, especially if promoting ethical photojournalism is the goal for 21st century global health

Observation of An Evolving Magnetic Flux Rope Prior To and During A Solar Eruption

Explosive energy release is a common phenomenon occurring in magnetized plasma systems ranging from laboratories, Earth's magnetosphere, the solar corona and astrophysical environments. Its physical explanation is usually attributed to magnetic reconnection in a thin current sheet. Here we report the important role of magnetic flux rope structure, a volumetric current channel, in producing explosive events. The flux rope is observed as a hot channel prior to and during a solar eruption from the Atmospheric Imaging Assembly (AIA) telescope on board the Solar Dynamic Observatory (SDO). It initially appears as a twisted and writhed sigmoidal structure with a temperature as high as 10 MK and then transforms toward a semi-circular shape during a slow rise phase, which is followed by fast acceleration and onset of a flare. The observations suggest that the instability of the magnetic flux rope trigger the eruption, thus making a major addition to the traditional magnetic-reconnection paradigm.Comment: 13 pages, 3 figure

Susceptible Workload Evaluation and Protection using Selective Fault Tolerance

Low power fault tolerance design techniques trade reliability to reduce the area cost and the power overhead of integrated circuits by protecting only a subset of their workload or their most vulnerable parts. However, in the presence of faults not all workloads are equally susceptible to errors. In this paper, we present a low power fault tolerance design technique that selects and protects the most susceptible workload. We propose to rank the workload susceptibility as the likelihood of any error to bypass the logic masking of the circuit and propagate to its outputs. The susceptible workload is protected by a partial Triple Modular Redundancy (TMR) scheme. We evaluate the proposed technique on timing-independent and timing-dependent errors induced by permanent and transient faults. In comparison with unranked selective fault tolerance approach, we demonstrate a) a similar error coverage with a 39.7% average reduction of the area overhead or b) a 86.9% average error coverage improvement for a similar area overhead. For the same area overhead case, we observe an error coverage improvement of 53.1% and 53.5% against permanent stuck-at and transition faults, respectively, and an average error coverage improvement of 151.8% and 89.0% against timing-dependent and timing-independent transient faults, respectively. Compared to TMR, the proposed technique achieves an area and power overhead reduction of 145.8% to 182.0%

Scalability approaches for causal multicast: a survey

The final publication is available at Springer via http://dx.doi.org/10.1007/s00607-015-0479-0Many distributed services need to be scalable: internet search, electronic commerce, e-government... In order to achieve scalability, high availability and fault tolerance, such applications rely on replicated components. Because of the dynamics of growth and volatility of customer markets, applications need to be hosted by adaptive, highly scalable systems. In particular, the scalability of the reliable multicast mechanisms used for supporting the consistency of replicas is of crucial importance. Reliable multicast might propagate updates in a pre-determined order (e.g., FIFO, total or causal). Since total order needs more communication rounds than causal order, the latter appears to be the preferable candidate for achieving multicast scalability, although the consistency guarantees based on causal order are weaker than those of total order. This paper provides a historical survey of different scalability approaches for reliable causal multicast protocols.This work was supported by European Regional Development Fund (FEDER) and Ministerio de Economia y Competitividad (MINECO) under research Grant TIN2012-37719-C03-01.Juan Marín, RD.; Decker, H.; Armendáriz Íñigo, JE.; Bernabeu Aubán, JM.; Muñoz Escoí, FD. (2016). Scalability approaches for causal multicast: a survey. Computing. 98(9):923-947. https://doi.org/10.1007/s00607-015-0479-0S923947989Adly N, Nagi M (1995) Maintaining causal order in large scale distributed systems using a logical hierarchy. In: IASTED Intnl Conf on Appl Inform, pp 214–219Aguilera MK, Chen W, Toueg S (1997) Heartbeat: a timeout-free failure detector for quiescent reliable communication. In: 11th Intnl Wshop on Distrib Alg (WDAG), Saarbrücken, pp 126–140Almeida JB, Almeida PS, Baquero C (2004) Bounded version vectors. In: 18th Intnl Conf Distrib Comput (DISC), Amsterdam, pp 102–116Almeida PS, Baquero C, Fonte V (2008) Interval tree clocks. In: 12th Intnl Conf Distrib Syst (OPODIS), Luxor, pp 259–274Almeida S, Leitão J, Rodrigues LET (2013) ChainReaction: a causal+ consistent datastore based on chain replication. In: 8th EuroSys Conf, Czech Republic, pp 85–98Álvarez A, Arévalo S, Cholvi V, Fernández A, Jiménez E (2008) On the interconnection of message passing systems. Inf Process Lett 105(6):249–254Amir Y, Stanton J (1998) The Spread wide area group communication system. Tech. rep., CDNS-98-4, The Center for Networking and Distributed Systems, The Johns Hopkins UnivAmir Y, Dolev D, Kramer S, Malki D (1992) Transis: a communication subsystem for high availability. In: 22nd Intnl Symp Fault-Tolerant Comp (FTCS), Boston, pp 76–84Anastasi G, Bartoli A, Spadoni F (2001) A reliable multicast protocol for distributed mobile systems: design and evaluation. IEEE Trans Parallel Distrib Syst 12(10):1009–1022Bailis P, Ghodsi A, Hellerstein JM, Stoica I (2013) Bolt-on causal consistency. In: Intnl Conf Mgmnt Data (SIGMOD), New York, pp 761–772Baldoni R, Raynal M, Prakash R, Singhal M (1996) Broadcast with time and causality constraints for multimedia applications. In: 22nd Intnl Euromicro Conf, Prague, pp 617–624Baldoni R, Friedman R, van Renesse R (1997) The hierarchical daisy architecture for causal delivery. In: 17th Intnl Conf Distrib Comput Syst (ICDCS), Maryland, pp 570–577Ban B (2002) JGroups—a toolkit for reliable multicast communication. http://www.jgroups.orgBaquero C, Almeida PS, Shoker A (2014) Making operation-based CRDTs operation-based. In: 14th Intnl Conf Distrib Appl Interop Syst (DAIS), Berlin, pp 126–140Benslimane A, Abouaissa A (2002) Dynamical grouping model for distributed real time causal ordering. Comput Commun 25:288–302Birman KP, Joseph TA (1987) Reliable communication in the presence of failures. ACM Trans Comput Syst 5(1):47–76Birman KP, Schiper A, Stephenson P (1991) Lightweigt causal and atomic group multicast. ACM Trans Comput Syst 9(3):272–314Cachin C, Guerraoui R, Rodrigues LET (2011) Introduction to reliable and secure distributed programming, 2nd edn. Springer, BerlinChandra P, Gambhire P, Kshemkalyani AD (2004) Performance of the optimal causal multicast algorithm: a statistical analysis. IEEE Trans Parall Distr 15(1):40–52Chandra TD, Toueg S (1996) Unreliable failure detectors for reliable distributed systems. J ACM 43(2):225–267de Juan-Marín R, Cholvi V, Jiménez E, Muñoz-Escoí FD (2009) Parallel interconnection of broadcast systems with multiple FIFO channels. In: 11th Intnl Symp on Distrib Obj, Middleware and Appl (DOA), Vilamoura, LNCS, vol 5870, pp 449–466Défago X, Schiper A, Urbán P (2004) Total order broadcast and multicast algorithms: taxonomy and survey. ACM Comput Surv 36(4):372–421Demers AJ, Greene DH, Hauser C, Irish W, Larson J, Shenker S, Sturgis HE, Swinehart DC, Terry DB (1987) Epidemic algorithms for replicated database maintenance. In: 6th ACM Symp on Princ of Distrib Comput (PODC), Canada, pp 1–12Du J, Elnikety S, Roy A, Zwaenepoel W (2013) Orbe: scalable causal consistency using dependency matrices and physical clocks. In: ACM Symp on Cloud Comput (SoCC), Santa Clara, pp 11:1–11:14Fernández A, Jiménez E, Cholvi V (2000) On the interconnection of causal memory systems. In: 19th Annual ACM Symp on Princ of Distrib Comput (PODC), Portland, pp 163–170Fidge CJ (1988) Timestamps in message-passing systems that preserve the partial ordering. In: 11th Australian Comput Conf, pp 56–66Friedman R, Vitenberg R, Chockler G (2003) On the composability of consistency conditions. Inf Process Lett 86(4):169–176Gilbert S, Lynch N (2002) Brewer’s conjecture and the feasibility of consistent, available, partition-tolerant web services. SIGACT News 33(2):51–59Gray J, Helland P, O’Neil PE, Shasha D (1996) The dangers of replication and a solution. In: SIGMOD Conf, pp 173–182Hadzilacos V, Toueg S (1993) Fault-tolerant broadcasts and related problems. In: Mullender S (ed) Distributed systems, chap 5, 2nd edn. ACM Press, pp 97–145Johnson S, Jahanian F, Shah J (1999) The inter-group router approach to scalable group composition. In: 19th Intnl Conf on Distrib Comput Syst (ICDCS), Austin, pp 4–14Kalantar MH, Birman KP (1999) Causally ordered multicast: the conservative approach. In: 19th Intnl Conf on Distrib Comput Syst (ICDCS), Austin, pp 36–44Kawanami S, Enokido T, Takizawa M (2004) A group communication protocol for scalable causal ordering. In: 18th Intnl Conf on Adv Inform Netw Appl (AINA), Fukuoka, pp 296–302Kawanami S, Nishimura T, Enokido T, Takizawa M (2005) A scalable group communication protocol with global clock. In: 19th Intnl Conf on Adv Inform Netw Appl (AINA), Taipei, pp 625–630Kshemkalyani AD, Singhal M (1998) Necessary and sufficient conditions on information for causal message ordering and their optimal implementation. Distrib Comput 11(2):91–111Kshemkalyani AD, Singhal M (2011) Distributed computing: principles, algorithms, and systems, 2nd edn. Cambridge University Press, New YorkLadin R, Liskov B, Shrira L, Ghemawat S (1992) Providing high availability using lazy replication. ACM Trans Comput Syst 10(4):360–391Lamport L (1978) Time, clocks, and the ordering of events in a distributed system. Commun ACM 21(7):558–565Laumay P, Bruneton E, de Palma N, Krakowiak S (2001) Preserving causality in a scalable message-oriented middleware. In: Intnl Conf on Distrib Syst Platf (Middleware), pp 311–328Liu N, Liu M, Cao J, Chen G, Lou W (2010) When transportation meets communication: V2P over VANETs. In: 30th Intnl Conf Distrib Comput Syst (ICDCS), GenovaLwin CH, Mohanty H, Ghosh RK (2004) Causal ordering in event notification service systems for mobile users. In: Intnl Conf Inform Tech: Coding Comput (ITCC), Las Vegas, pp 735–740Mahajan P, Alvisi L, Dahlin M (2011) Consistency, availability and covergence. Tech. rep., UTCS TR-11-22, The University of Texas at AustinMatos M, Sousa A, Pereira J, Oliveira R, Deliot E, Murray P (2009) CLON: overlay networks and gossip protocols for cloud environments. In: 11th Intnl Symp on Dist Obj, Middleware and Appl (DOA), Vilamoura, LNCS, vol 5870, pp 549–566Mattern F (1989) Virtual time and global states of distributed systems. In: Parallel and distributed algorithms, North-Holland, pp 215–226Mattern F, Fünfrocken S (1994) A non-blocking lightweight implementation of causal order message delivery. Lect Notes Comput Sci 938:197–213Meldal S, Sankar S, Vera J (1991) Exploiting locality in maintaining potential causality. In: 10th ACM Symp on Princ of Distrib Comp (PODC), Montreal, pp 231–239Meling H, Montresor A, Helvik BE, Babaoglu Ö (2008) Jgroup/ARM: a distributed object group platform with autonomous replication management. Softw Pract Exp 38(9):885–923Mosberger D (1993) Memory consistency models. Oper Syst Rev 27(1):18–26Mostéfaoui A, Raynal M (1993) Causal multicast in overlapping groups: towards a low cost approach. In: 4th Intnl Wshop on Future Trends of Distrib Comp Syst (FTDCS), Lisbon, pp 136–142Mostéfaoui A, Raynal M, Travers C, Patterson S, Agrawal D, El Abbadi A (2005) From static distributed systems to dynamic systems. In: 24th Symp on Rel Distrib Syst (SRDS), Orlando, pp 109–118Nishimura T, Hayashibara N, Takizawa M, Enokido T (2005) Causally ordered delivery with global clock in hierarchical group. In: ICPADS (2), Fukuoka, pp 560–564Parker DS Jr, Popek GJ, Rudisin G, Stoughton A, Walker BJ, Walton E, Chow JM, Edwards DA, Kiser S, Kline CS (1983) Detection of mutual inconsistency in distributed systems. IEEE Trans Softw Eng 9(3):240–247Pascual-Miret L (2014) Consistency models in modern distributed systems. An approach to eventual consistency. Master’s thesis, Depto. de Sistemas Informáticos y Computación, Univ. Politècnica de ValènciaPascual-Miret L, González de Mendívil JR, Bernabéu-Aubán JM, Muñoz-Escoí FD (2015) Widening CAP consistency. Tech. rep., IUMTI-SIDI-2015/003, Univ. Politècnica de València, ValenciaPeterson LL, Buchholz NC, Schlichting RD (1989) Preserving and using context information in interprocess communication. ACM Trans Comput Syst 7(3):217–246Pomares Hernández S, Fanchon J, Drira K, Diaz M (2001) Causal broadcast protocol for very large group communication systems. In: 5th Intnl Conf on Princ of Distrib Syst (OPODIS), Manzanillo, pp 175–188Prakash R, Baldoni R (2004) Causality and the spatial-temporal ordering in mobile systems. Mobile Netw Appl 9(5):507–516Prakash R, Raynal M, Singhal M (1997) An adaptive causal ordering algorithm suited to mobile computing environments. J Parallel Distrib Comput 41(2):190–204Raynal M, Schiper A, Toueg S (1991) The causal ordering abstraction and a simple way to implement it. Inf Process Lett 39(6):343–350Rodrigues L, Veríssimo P (1995a) Causal separators and topological timestamping: An approach to support causal multicast in large-scale systems. Tech. Rep. AR-05/95, Instituto de Engenharia de Sistemas e Computadores (INESC), LisbonRodrigues L, Veríssimo P (1995b) Causal separators for large-scale multicast communication. In: 15th Intnl Conf on Distrib Comput Syst (ICDCS), Vancouver, pp 83–91Schiper A, Eggli J, Sandoz A (1989) A new algorithm to implement causal ordering. In: 3rd Intnl Wshop on Distrib Alg (WDAG), Nice, pp 219–232Schiper N, Pedone F (2010) Fast, flexible and highly resilient genuine FIFO and causal multicast algorithms. In: 25th ACM Symp on Applied Comp (SAC), Sierre, pp 418–422Shapiro M, Preguiça NM, Baquero C, Zawirski M (2011) Convergent and commutative replicated data types. Bull EATCS 104:67–88Shen M, Kshemkalyani AD, Hsu TY (2015) Causal consistency for geo-replicated cloud storage under partial replication. In: Intnl Paral Distrib Proces Symp (IPDPS) Wshop, Hyderabad, pp 509–518Singhal M, Kshemkalyani AD (1992) An efficient implementation of vector clocks. Inf Process Lett 43(1):47–52Sotomayor B, Montero RS, Llorente IM, Foster IT (2009) Virtual infrastructure management in private and hybrid clouds. IEEE Internet Comput 13(5):14–22Stephenson P (1991) Fast ordered multicasts. PhD thesis, Dept. of Comp. Sc., Cornell Univ., IthacaStonebraker M (1986) The case for shared nothing. IEEE Database Eng Bull 9(1):4–9Vogels W (2009) Eventually consistent. Commun ACM 52(1):40–44Wischhof L, Ebner A, Rohling H (2005) Information dissemination in self-organizing intervehicle networks. IEEE Trans Intell Transp 6(1):90–101Yavatkar R (1992) MCP: a protocol for coordination and temporal synchronization in multimedia collaborative applications. In: 12th Intnl Conf on Distrib Comput Syst (ICDCS), Yokohama, pp 606–613Yen LH, Huang TL, Hwang SY (1997) A protocol for causally ordered message delivery in mobile computing systems. Mobile Netw Appl 2(4):365–372Zawirski M, Preguiça N, Duarte S, Bieniusa A, Balegas V, Shapiro M (2015) Write fast, read in the past: causal consistency for client-side applications. In: 16th Intnl Middleware Conf, VancouverZhou S, Cai W, Turner SJ, Lee BS, Wei J (2007) Critical causal order of events in distributed virtual environments. ACM Trans Mult Comp Commun Appl 3(3):1

ASCOT: a text mining-based web-service for efficient search and assisted creation of clinical trials

Clinical trials are mandatory protocols describing medical research on humans and among the most valuable sources of medical practice evidence. Searching for trials relevant to some query is laborious due to the immense number of existing protocols. Apart from search, writing new trials includes composing detailed eligibility criteria, which might be time-consuming, especially for new researchers. In this paper we present ASCOT, an efficient search application customised for clinical trials. ASCOT uses text mining and data mining methods to enrich clinical trials with metadata, that in turn serve as effective tools to narrow down search. In addition, ASCOT integrates a component for recommending eligibility criteria based on a set of selected protocols