Multicenter questionnaire survey for sporadic inclusion body myositis in Japan

Background: Sporadic inclusion body myositis (sIBM) is the most prevalent acquired muscle disease in the elderly. sIBM is an intractable and progressive disease of unknown cause and without effective treatment. The etiology of sIBM is still unknown; however, genetic factors, aging, lifestyles, and environmental factors may be involved. The purpose of this study is to elucidate the cross-sectional profile of patients affected by sIBM in Japan. Methods: We surveyed patient data for 146 cases diagnosed at a number of centers across Japan. We also issued a questionnaire for 67 patients and direct caregivers to further elucidate the natural history of the disease. Results: The mean age at the onset was 63.4 ± 9.2 years. The mean length of time from the onset to diagnosis was 55.52 ± 49.72 months, suggesting that there is a difficulty in diagnosing this disease with long-term consequences because of late treatment. 73 % described the psychological/mental aspect of the disease. The most popular primary caregiver was the patient’s spouse and 57 % patients mentioned that they were having problems managing the finances. Conclusions: Through these surveys, we described the cross-sectional profiles of sIBM in Japan. Many patients described psychological/mental and financial anxiety because of the aged profile of sIBM patients. The profiles of sIBM patients are similar to those in Western countries

The updated retrospective questionnaire study of sporadic inclusion body myositis in Japan

Background: Sporadic inclusion body myositis (sIBM) is the most prevalent muscle disease in elderly people, affecting the daily activities. sIBM is progressive with unknown cause and without effective treatment. In 2015, sIBM was classified as an intractable disease by the Japanese government, and the treatment cost was partly covered by the government. This study aimed to examine the changes in the number of patients with sIBM over the last 10 years and to elucidate the cross-sectional profile of Japanese patients with sIBM. Methods: The number of sIBM patients was estimated through a reply-paid postcard questionnaire for attending physicians. Only patients diagnosed as “definite” or “probable” sIBM by clinical and biopsy sIBM criteria were included in this study (Lancet Neurol 6:620-631, 2007, Neuromuscul Disord 23:1044-1055, 2013). Additionally, a registered selfadministered questionnaire was also sent to 106 patients who agreed to reply via their attending physician, between November 2016 and March 2017. Results: The number of patients diagnosed with sIBM for each 5-year period was 286 and 384 in 2011 and 2016, respectively. Inability to stand-up, cane-dependent gait, inability to open a plastic bottle, choking on food ingestion, and being wheelchair-bound should be included as sIBM milestones. Eight patients were positive for anti-hepatitis C virus antibody; three of them were administered interferon before sIBM onset. Steroids were administered to 33 patients (31.1%) and intravenous immunoglobulin to 46 patients (43.4%). From 2016 to 2017, total of 70 patients applied for the designated incurable disease medical expenses subsidy program. Although the treatment cost was partly covered by the government, many patients expressed psychological/mental and financial anxieties. Conclusions: We determined the cross-sectional profile of Japanese patients with sIBM. Continuous support and prospective surveys are warranted

Free-Floating planet Mass Function from MOA-II 9-year survey towards the Galactic Bulge

We present the first measurement of the mass function of free-floating planets (FFP) or very wide orbit planets down to an Earth mass, from the MOA-II microlensing survey in 2006-2014. Six events are likely to be due to planets with Einstein radius crossing times, $t_{\rm E}<0.5$days, and the shortest has $t_{\rm E} = 0.057\pm 0.016$days and an angular Einstein radius of $\theta_{\rm E} = 0.90\pm 0.14\mu$as. We measure the detection efficiency depending on both $t_{\rm E}$ and $\theta_{\rm E}$ with image level simulations for the first time. These short events are well modeled by a power-law mass function, $dN_4/d\log M = (2.18^{+0.52}_{-1.40})\times (M/8\,M_\oplus)^{-\alpha_4}$ dex$^{-1}$star$^{-1}$ with $\alpha_4 = 0.96^{+0.47}_{-0.27}$ for $M/M_\odot < 0.02$. This implies a total of $f= 21^{+23}_{-13}$ FFP or very wide orbit planets of mass $0.33<M/M_\oplus < 6660$ per star, with a total mass of $80^{+73}_{-47} M_\oplus$ per star. The number of FFPs is $19_{-13}^{+23}$ times the number of planets in wide orbits (beyond the snow line), while the total masses are of the same order. This suggests that the FFPs have been ejected from bound planetary systems that may have had an initial mass function with a power-law index of $\alpha\sim 0.9$, which would imply a total mass of $171_{-52}^{+80} M_\oplus$ star$^{-1}$. This model predicts that Roman Space Telescope will detect $988^{+1848}_{-566}$ FFPs with masses down to that of Mars (including $575^{+1733}_{ -424}$ with $0.1 \le M/M_\oplus \le 1$). The Sumi(2011) large Jupiter-mass FFP population is excluded.Comment: 17 pages, 7 figures, accepted for publication in A

KMT-2021-BLG-1150Lb: Microlensing planet detected through a densely covered planetary-caustic signal

Recently, there have been reports of various types of degeneracies in the interpretation of planetary signals induced by planetary caustics. In this work, we check whether such degeneracies persist in the case of well-covered signals by analyzing the lensing event KMT-2021-BLG-1150, for which the light curve exhibits a densely and continuously covered short-term anomaly. In order to identify degenerate solutions, we thoroughly investigate the parameter space by conducting dense grid searches for the lensing parameters. We then check the severity of the degeneracy among the identified solutions. We identify a pair of planetary solutions resulting from the well-known inner-outer degeneracy, and find that interpreting the anomaly is not subject to any degeneracy other than the inner-outer degeneracy. The measured parameters of the planet separation (normalized to the Einstein radius) and mass ratio between the lens components are $(s, q)_{\rm in}\sim (1.297, 1.10\times 10^{-3})$ for the inner solution and $(s, q)_{\rm out}\sim (1.242, 1.15\times 10^{-3})$ for the outer solution. According to a Bayesian estimation, the lens is a planetary system consisting of a planet with a mass $M_{\rm p}=0.88^{+0.38}_{-0.36}~M_{\rm J}$ and its host with a mass $M_{\rm h}=0.73^{+0.32}_{-0.30}~M_\odot$ lying toward the Galactic center at a distance $D_{\rm L} =3.8^{+1.3}_{-1.2}$~kpc. By conducting analyses using mock data sets prepared to mimic those obtained with data gaps and under various observational cadences, it is found that gaps in data can result in various degenerate solutions, while the observational cadence does not pose a serious degeneracy problem as long as the anomaly feature can be delineated.Comment: 9 pages, 8 figure

KMT-2021-BLG-1547Lb: Giant microlensing planet detected through a signal deformed by source binarity

We investigate the previous microlensing data collected by the KMTNet survey in search of anomalous events for which no precise interpretations of the anomalies have been suggested. From this investigation, we find that the anomaly in the lensing light curve of the event KMT-2021-BLG-1547 is approximately described by a binary-lens (2L1S) model with a lens possessing a giant planet, but the model leaves unexplained residuals. We investigate the origin of the residuals by testing more sophisticated models that include either an extra lens component (3L1S model) or an extra source star (2L2S model) to the 2L1S configuration of the lens system. From these analyses, we find that the residuals from the 2L1S model originate from the existence of a faint companion to the source. The 2L2S solution substantially reduces the residuals and improves the model fit by $\Delta\chi^2=67.1$ with respect to the 2L1S solution. The 3L1S solution also improves the fit, but its fit is worse than that of the 2L2S solution by $\Delta\chi^2=24.7$. According to the 2L2S solution, the lens of the event is a planetary system with planet and host masses $(M_{\rm p}/M_{\rm J}, M_{\rm h}/M_\odot)=\left( 1.47^{+0.64}_{-0.77}, 0.72^{+0.32}_{-0.38}\right)$ lying at a distance \D_{\rm L} =5.07^{+0.98}_{-1.50}~kpc, and the source is a binary composed of a subgiant primary of a late G or an early K spectral type and a main-sequence companion of a K spectral type. The event demonstrates the need of sophisticated modeling for unexplained anomalies for the construction of a complete microlensing planet sample.Comment: 9 pages, 4 tables, 7 figure

Systematic KMTNet Planetary Anomaly Search. IX. Complete Sample of 2016 Prime-Field Planets

As a part of the ``Systematic KMTNet Planetary Anomaly Search" series, we report five new planets (namely, OGLE-2016-BLG-1635Lb, MOA-2016-BLG-532Lb, KMT-2016-BLG-0625Lb, OGLE-2016-BLG-1850Lb, and KMT-2016-BLG-1751Lb) and one planet candidate (KMT-2016-BLG-1855), which were found by searching $2016$ KMTNet prime fields. These $buried$ planets show a wide range of masses from Earth--class to Super--Jupiter--class, and are located in both the disk and the bulge. The ultimate goal of this series is to build a complete planet sample. Because our work provides a complementary sample to other planet detection methods, which have different detection sensitivities, our complete sample will help us to obtain a better understanding of planet demographics in our Galaxy.Comment: 38 pages, 17 figures, 12 Tables, submitted to the AAS journa

KMT-2022-BLG-0440Lb: A New q<10−4q < 10^{-4} Microlensing Planet with the Central-Resonant Caustic Degeneracy Broken

We present the observations and analysis of a high-magnification microlensing planetary event, KMT-2022-BLG-0440, for which the weak and short-lived planetary signal was covered by both the KMTNet survey and follow-up observations. The binary-lens models with a central caustic provide the best fits, with a planet/host mass ratio, $q = 0.75$--$1.00 \times 10^{-4}$ at $1\sigma$. The binary-lens models with a resonant caustic and a brown-dwarf mass ratio are both excluded by $\Delta\chi^2 > 70$. The binary-source model can fit the anomaly well but is rejected by the ``color argument'' on the second source. From Bayesian analyses, it is estimated that the host star is likely a K or M dwarf located in the Galactic disk, the planet probably has a Neptune-mass, and the projected planet-host separation is $1.9^{+0.6}_{-0.7}$ or $4.6^{+1.4}_{-1.7}$ au, subject to the close/wide degeneracy. This is the third $q < 10^{-4}$ planet from a high-magnification planetary signal ($A \gtrsim 65$). Together with another such planet, KMT-2021-BLG-0171Lb, the ongoing follow-up program for the KMTNet high-magnification events has demonstrated its ability in detecting high-magnification planetary signals for $q < 10^{-4}$ planets, which are challenging for the current microlensing surveys.Comment: MNRAS accepte

KMT-2023-BLG-1431Lb: A New q<10−4q < 10^{-4} Microlensing Planet from a Subtle Signature

The current studies of microlensing planets are limited by small number statistics. Follow-up observations of high-magnification microlensing events can efficiently form a statistical planetary sample. Since 2020, the Korea Microlensing Telescope Network (KMTNet) and the Las Cumbres Observatory (LCO) global network have been conducting a follow-up program for high-magnification KMTNet events. Here, we report the detection and analysis of a microlensing planetary event, KMT-2023-BLG-1431, for which the subtle (0.05 magnitude) and short-lived (5 hours) planetary signature was characterized by the follow-up from KMTNet and LCO. A binary-lens single-source (2L1S) analysis reveals a planet/host mass ratio of $q = (0.72 \pm 0.07) \times 10^{-4}$, and the single-lens binary-source (1L2S) model is excluded by $\Delta\chi^2 = 80$. A Bayesian analysis using a Galactic model yields estimates of the host star mass of $M_{\rm host} = 0.57^{+0.33}_{-0.29}~M_\odot$, the planetary mass of $M_{\rm planet} = 13.5_{-6.8}^{+8.1}~M_{\oplus}$, and the lens distance of $D_{\rm L} = 6.9_{-1.7}^{+0.8}$ kpc. The projected planet-host separation of $a_\perp = 2.3_{-0.5}^{+0.5}$ au or $a_\perp = 3.2_{-0.8}^{+0.7}$, subject to the close/wide degeneracy. We also find that without the follow-up data, the survey-only data cannot break the degeneracy of central/resonant caustics and the degeneracy of 2L1S/1L2S models, showing the importance of follow-up observations for current microlensing surveys.Comment: PASP submitted. arXiv admin note: text overlap with arXiv:2301.0677

OGLE-2019-BLG-0825: Constraints on the Source System and Effect on Binary-lens Parameters arising from a Five Day Xallarap Effect in a Candidate Planetary Microlensing Event

We present an analysis of microlensing event OGLE-2019-BLG-0825. This event was identified as a planetary candidate by preliminary modeling. We find that significant residuals from the best-fit static binary-lens model exist and a xallarap effect can fit the residuals very well and significantly improves $\chi^2$ values. On the other hand, by including the xallarap effect in our models, we find that binary-lens parameters like mass-ratio, $q$, and separation, $s$, cannot be constrained well. However, we also find that the parameters for the source system like the orbital period and semi major axis are consistent between all the models we analyzed. We therefore constrain the properties of the source system better than the properties of the lens system. The source system comprises a G-type main-sequence star orbited by a brown dwarf with a period of $P\sim5$ days. This analysis is the first to demonstrate that the xallarap effect does affect binary-lens parameters in planetary events. It would not be common for the presence or absence of the xallarap effect to affect lens parameters in events with long orbital periods of the source system or events with transits to caustics, but in other cases, such as this event, the xallarap effect can affect binary-lens parameters.Comment: 19 pages, 7 figures, 6 tables. Accepted by A