PLASMA RENIN ACTIVITY IN PATIENTS WITH CHRONIC RENAL FAILURE BEFORE AND AFTER HEMODIALYSIS

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AUTO-IMMUNITY IN CHRONIC ADRENAL INSUFFICIENCY

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CLINICO-LABORATORY CHARACTERISTICS AND PATHOGENETIC FEATURES OF THE MORGAGNI-STEWART-MOREL SYNDROME

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CHANGES IN THE FUNCTIONAL STATE OF THE LIVER IN THYROTOXICOSIS PATIENTS

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EFFECTIVENESS OF DIABETIC KETOACIDOSIS TREATMENT WITH LOW-DOSIS VENOUS INSULIN INFUSIONS

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IMMUNE RESPONSE IN MALIGNANT GLIOMA

Objective: Malignant gliomas are primary brain tumors with excessive mortality and high resistance to chemotherapy and radiotherapy. The survival time for glioblastoma multi­forme is about 6-12 months. As key pathogenetic mechanisms are recognized the massive necrosis, angiogenesis and hypoxia within the tumor, as well as the resistance to apoptosis. It is also suspected that altered immune response might contribute to the fatal clinical outcome.The aim of the present study was to determine the immune status of patients with malignant gliomas.Material and methods: Peripheral blood lymphocytes were collected preoperatively from 9 patients (aged 57-76) diagnosed as anaplastic astrocytoma grade III (n=4) and glioblastoma multiforme (n=5). The following lymphocyte populations were analyzed by flow cytometry: CD19+, CD3+, CD3+CD4+, CD3+CD8+, CD3-CD56+, CD3+CD56+, CD3+CD25+, CD8-CD11b+, CD8+CD11b+, CD8+CD11b-. The results obtained were compared to reference values for each cell population.Results: No significant alterations were detected in CD19+, CD3+, CD3+CD4+, CD3+CD8+ cells, but the CD4/CD8 ratio was below the reference range in some cases. No obvious decrease in (CD3-CD56+) NK cells and (CD3-CD56+) NKT cells was observed in most patients. A reproducible phenomenon of increased CD8+CD11b+ and decreased CD8+CD11b- cells was noticed. These preliminary results suggest that the immune response in patients with malignant glioma is seriously disregulated. The rapid clinical deterioration, relapses and high mortality could be at least partially explained with the suppressed activity of NK-cells which are the major cytotoxic antitumoral cells. The increase in the population of activated suppressor-effector cells also contributes to the unfavourable outcome in malignant brain tumors.Conclusion: This pilot study reveals the presence of altered immune response in malignant gliomas and opens possibilities for prospective investigations concerning immune status and clinical outcome

Asymptotics for products of characteristic polynomials in classical β\beta-Ensembles

We study the local properties of eigenvalues for the Hermite (Gaussian), Laguerre (Chiral) and Jacobi $\beta$-ensembles of $N\times N$ random matrices. More specifically, we calculate scaling limits of the expectation value of products of characteristic polynomials as $N\to\infty$. In the bulk of the spectrum of each $\beta$-ensemble, the same scaling limit is found to be $e^{p_{1}}{}_1F_{1}$ whose exact expansion in terms of Jack polynomials is well known. The scaling limit at the soft edge of the spectrum for the Hermite and Laguerre $\beta$-ensembles is shown to be a multivariate Airy function, which is defined as a generalized Kontsevich integral. As corollaries, when $\beta$ is even, scaling limits of the $k$-point correlation functions for the three ensembles are obtained. The asymptotics of the multivariate Airy function for large and small arguments is also given. All the asymptotic results rely on a generalization of Watson's lemma and the steepest descent method for integrals of Selberg type.Comment: [v3] 35 pages; this is a revised and enlarged version of the article with new references, simplified demonstations, and improved presentation. To be published in Constructive Approximation 37 (2013

А Меаsuring Method for Gyro-Free Determination of the Parameters of Moving Objects

The paper presents a new method for building measuring instruments and systems for gyro-free determination of the parameters of moving objects. To illustrate the qualities of this method, a system for measuring the roll, pitch, heel and trim of a ship has been developed on its basis. The main concept of the method is based, on one hand, on a simplified design of the base coordinate system in the main measurement channel so as to reduce the instrumental errors, and, on the other hand, on an additional measurement channel operating in parallel with the main one and whose hardware and software platform makes possible performing algorithms intended to eliminate the dynamic error in real time. In this way, as well as by using suitable adaptive algorithms in the measurement procedures, low-cost measuring systems operating with high accuracy under conditions of inertial effects and whose parameters (intensity and frequency of the maximum in the spectrum) change within a wide range can be implemented

A Model of the Dynamic Error as a Measurement Result of Instruments Defining the Parameters of Moving Objects

The present paper considers a new model for the formation of the dynamic error inertial component. It is very effective in the analysis and synthesis of measuring instruments positioned on moving objects and measuring their movement parameters. The block diagram developed within this paper is used as a basis for defining the mathematical model. The block diagram is based on the set-theoretic description of the measuring system, its input and output quantities and the process of dynamic error formation. The model reflects the specific nature of the formation of the dynamic error inertial component. In addition, the model submits to the logical interrelation and sequence of the physical processes that form it. The effectiveness, usefulness and advantages of the model proposed are rooted in the wide range of possibilities it provides in relation to the analysis and synthesis of those measuring instruments, the formulation of algorithms and optimization criteria, as well as the development of new intelligent measuring systems with improved accuracy characteristics in dynamic mode