3 research outputs found
Effects of steady state free precession parameters on cardiac mass, function, and volumes
G0400444/Medical Research Council/United Kingdom
Wellcome Trust/United Kingdo
Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented