Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Reducing Potential Sources of Sampling Bias When Quantifying the Diet of the African Wild Dog Through Scat Analysis

To develop guidelines for the collection of independent field samples of scats for the quantification of wild dog (Lycaon pictus) diet we determined the passage rates of different wild dog prey items from feeding trials on a captive pack held at Marakele National Park, Limpopo Province. The minimum time to first detection was 5.5 hours after feeding (S.E. ± 1.52, n = 5) and prey items remained in the gut for an average of 79.4 hours (S.E. ± 6.00, n = 3). Differential passage rates of prey species were not pronounced. Observed passage rates were used to devise a sampling protocol for scats collected during a field study where scats were separated by a minimum period of 120 hours to ensure independence of samples. Comparison of the percentage occurrence of prey species in field-collected scats with the percentage occurrence from direct observations of kills illustrated the tendency for small prey to be underrepresented in the latter. However, the strong correlation between percentage occurrences in diet as determined by the two methods (rs = 0.85, P < 0.01, 13 d.f.) suggests that both methods can reliably determine the relative importance of prey in the diets of obligate carnivores such as wild dogs.The determination of maximum passage rates and subsequent guidelines for collection of independent faecal samples in the field could be a valuable tool for reducing inherent biases in carnivore diet studies

Power, inequality and identification: exploring diversity and intersectionality amongst older LGB adults

This article explores how theories of diversity and intersectionality can improve our understandings of the lives of older lesbian, gay and bisexual (LGB) adults. In so doing, it argues that theories of diversity help us to understand both the structural constraints and the advantages that may arise from being an older LGB adult. However, these theories are unable to fully account for differences that may exist within this social group. In order to address this omission, we argue that we need to move beyond a focus on diversity per se, to incorporate the multiplicity of identities suggested by intersectionality theory. We conclude by assessing the implications of this debate for policy and research. Throughout the article we draw on existing research as well as our own empirical studies with older LGB adults