Hammerhead, an ultrahigh resolution ePix camera for wavelength-dispersive spectrometers

Wavelength-dispersive spectrometers (WDS) are often used in synchrotron and FEL applications where high energy resolution (in the order of eV) is important. Increasing WDS energy resolution requires increasing spatial resolution of the detectors in the dispersion direction. The common approaches with strip detectors or small pixel detectors are not ideal. We present a novel approach, with a sensor using rectangular pixels with a high aspect ratio (between strips and pixels, further called "strixels"), and strixel redistribution to match the square pixel arrays of typical ASICs while avoiding the considerable effort of redesigning ASICs. This results in a sensor area of 17.4 mm x 77 mm, with a fine pitch of 25 $\mu$m in the horizontal direction resulting in 3072 columns and 176 rows. The sensors use ePix100 readout ASICs, leveraging their low noise (43 e$^-$, or 180 eV rms). We present results obtained with a Hammerhead ePix100 camera, showing that the small pitch (25 $\mu$m) in the dispersion direction maximizes performance for both high and low photon occupancies, resulting in optimal WDS energy resolution. The low noise level at high photon occupancy allows precise photon counting, while at low occupancy, both the energy and the subpixel position can be reconstructed for every photon, allowing an ultrahigh resolution (in the order of 1 $\mu$m) in the dispersion direction and rejection of scattered beam and harmonics. Using strixel sensors with redistribution and flip-chip bonding to standard ePix readout ASICs results in ultrahigh position resolution ($\sim$1 $\mu$m) and low noise in WDS applications, leveraging the advantages of hybrid pixel detectors (high production yield, good availability, relatively inexpensive) while minimizing development complexity through sharing the ASIC, hardware, software and DAQ development with existing versions of ePix cameras.Comment: 8 pages, 6 figure

Ongoing Gas Stripping in the Virgo Cluster Spiral NGC 4522

The Virgo cluster galaxy NGC 4522 is one of the best spiral candidates for ICM-ISM stripping in action. Optical broadband and H-alpha images from the WIYN telescope of the highly inclined galaxy reveal a relatively undisturbed stellar disk and a peculiar distribution of H-alpha emission. Ten percent of the H-alpha emission arises from extraplanar HII regions which appear to lie within filamentary structures >3 kpc long above one side of the disk. The filaments emerge from the outer edge of a disk of bright H-alpha emission which is abruptly truncated beyond 0.35R(25). Together the truncated H-alpha disk and extraplanar H-alpha filaments are reminiscent of a bow shock morphology, which strongly suggests that the interstellar medium (ISM) of NGC 4522 is being stripped by the gas pressure of the intracluster medium (ICM). The galaxy has a line-of-sight velocity of 1300 km/sec with respect to the mean Virgo cluster velocity, and thus is expected to experience a strong interaction with the intracluster gas. The existence of HII regions apparently located above the disk plane suggests that star formation is occuring in the stripped gas, and that newly formed stars will enter the galaxy halo and/or intracluster space. The absence of HII regions in the disk beyond 0.35R(25), and the existence of HII regions in the stripped gas suggest that even molecular gas has been effectively removed from the disk of the galaxy.Comment: to appear in The Astronomical Journal, 16 pages, 5 figures, 1 tabl

Hubble Space Telescope Imaging of the Ultra-Compact High Velocity Cloud AGC 226067: A stripped remnant in the Virgo Cluster

We analyze the optical counterpart to the ultra-compact high velocity cloud AGC 226067, utilizing imaging taken with the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope. The color magnitude diagram of the main body of AGC 226067 reveals an exclusively young stellar population, with an age of $\sim$7--50 Myr, and is consistent with a metallicity of [Fe/H]$\sim$$-$0.3 as previous work has measured via HII region spectroscopy. Additionally, the color magnitude diagram is consistent with a distance of $D$$\approx$17 Mpc, suggesting an association with the Virgo cluster. A secondary stellar system located $\sim$1.6' ($\sim$8 kpc) away in projection has a similar stellar population. The lack of an old red giant branch ($\gtrsim$5 Gyr) is contrasted with a serendipitously discovered Virgo dwarf in the ACS field of view (Dw J122147+132853), and the total diffuse light from AGC~226067 is consistent with the luminosity function of the resolved $\sim$7--50 Myr stellar population. The main body of AGC~226067 has a $M_{V}$=$-$11.3$\pm$0.3, or $M_{stars}$=5.4$\pm$1.3$\times$10$^4$ $M_{\odot}$ given the stellar population. We searched 20 deg$^2$ of imaging data adjacent to AGC~226067 in the Virgo Cluster, and found two similar stellar systems dominated by a blue stellar population, far from any massive galaxy counterpart -- if this population has similar star formation properties as AGC~226067, it implies $\sim$0.1 $M_{\odot}$ yr$^{-1}$ in Virgo intracluster star formation. Given its unusual stellar population, AGC~226067 is likely a stripped remnant and is plausibly the result of compressed gas from the ram pressure stripped M86 subgroup ($\sim$350 kpc away in projection) as it falls into the Virgo Cluster.Comment: 9 pages, 4 figures, 1 table. Accepted by the Astrophysical Journa

Static Pressure of Hot Gas: Its Effect on the Gas Disks of Galaxies

The static pressure of the hot gas that fills clusters and groups of galaxies can affect significantly the volume density and thickness of the gas disks in galaxies. In combination with the dynamic pressure, the static pressure allows several observed peculiarities of spiral galaxies surrounded by a hot medium to be explained.Comment: 9 pages, 2 figures. This is a slightly modified version of the paper published in Astronomy Letters 2008, Vol. 34, No 11, p. 73

Epstein-Barr Virus Immediate-Early Protein BRLF1 Induces the Lytic Form of Viral Replication through a Mechanism Involving Phosphatidylinositol-3 Kinase Activation

Expression of the Epstein-Barr virus (EBV) immediate-early (IE) protein BRLF1 induces the lytic form of viral replication in most EBV-positive cell lines. BRLF1 is a transcriptional activator that binds directly to a GC-rich motif present in some EBV lytic gene promoters. However, BRLF1 activates transcription of the other IE protein, BZLF1, through an indirect mechanism which we previously showed to require activation of the stress mitogen-activated protein kinases. Here we demonstrate that BRLF1 activates phosphatidylinositol-3 (PI3) kinase signaling in host cells. We show that the specific PI3 kinase inhibitor, LY294002, completely abrogates the ability of a BRLF1 adenovirus vector to induce the lytic form of EBV infection, while not affecting lytic infection induced by a BZLF1 adenovirus vector. Furthermore, we demonstrate that the requirement for PI3 kinase activation in BRLF1-induced transcriptional activation is promoter dependent. BRLF1 activation of the SM early promoter (which occurs through a direct binding mechanism) does not require PI3 kinase activation, whereas activation of the IE BZLF1 and early BMRF1 promoters requires PI3 kinase activation. Thus, there are clearly two separate mechanisms by which BRLF1 induces transcriptional activation

The SKA Particle Array Prototype: The First Particle Detector at the Murchison Radio-astronomy Observatory

We report on the design, deployment, and first results from a scintillation detector deployed at the Murchison Radio-astronomy Observatory (MRO). The detector is a prototype for a larger array -- the Square Kilometre Array Particle Array (SKAPA) -- planned to allow the radio-detection of cosmic rays with the Murchison Widefield Array and the low-frequency component of the Square Kilometre Array. The prototype design has been driven by stringent limits on radio emissions at the MRO, and to ensure survivability in a desert environment. Using data taken from Nov.\ 2018 to Feb.\ 2019, we characterize the detector response while accounting for the effects of temperature fluctuations, and calibrate the sensitivity of the prototype detector to through-going muons. This verifies the feasibility of cosmic ray detection at the MRO. We then estimate the required parameters of a planned array of eight such detectors to be used to trigger radio observations by the Murchison Widefield Array.Comment: 17 pages, 14 figures, 3 table

Tetrabenazine as anti-chorea therapy in Huntington Disease: an open-label continuation study. Huntington Study Group/TETRA-HD Investigators

<p>Abstract</p> <p>Background</p> <p>Tetrabenazine (TBZ) selectively depletes central monoamines by reversibly binding to the type-2 vesicular monoamine transporter. A previous double blind study in Huntington disease (HD) demonstrated that TBZ effectively suppressed chorea, with a favorable short-term safety profile (<it>Neurology </it>2006;66:366-372). The objective of this study was to assess the long-term safety and effectiveness of TBZ for chorea in HD.</p> <p>Methods</p> <p>Subjects who completed the 13-week, double blind protocol were invited to participate in this open label extension study for up to 80 weeks. Subjects were titrated to the best individual dose or a maximum of 200 mg/day. Chorea was assessed using the Total Maximal Chorea (TMC) score from the Unified Huntington Disease Rating Scale.</p> <p>Results</p> <p>Of the 75 participants, 45 subjects completed 80 weeks. Three participants terminated due to adverse events (AEs) including depression, delusions with associated previous suicidal behavior, and vocal tics. One subject died due to breast cancer. The other 26 subjects chose not to continue on with each ensuing extension for various reasons. When mild and unrelated AEs were excluded, the most commonly reported AEs (number of subjects) were sedation/somnolence (18), depressed mood (17), anxiety (13), insomnia (10), and akathisia (9). Parkinsonism and dysphagia scores were significantly increased at week 80 compared to baseline. At week 80, chorea had significantly improved from baseline with a mean reduction in the TMC score of 4.6 (SD 5.5) units. The mean dosage at week 80 was 63.4 mg (range 12.5-175 mg).</p> <p>Conclusions</p> <p>TBZ effectively suppresses HD-related chorea for up to 80 weeks. Patients treated chronically with TBZ should be monitored for parkinsonism, dysphagia and other side effects including sleep disturbance, depression, anxiety, and akathisia.</p> <p>Trial Registration</p> <p>Clinicaltrials.gov registration number (initial study): NCT00219804</p