The Determinants of Knowability

Many propositions are not known to be true or false, andmany phenomena are not understood. What determineswhat propositions and phenomena are perceived asknowable or unknowable? We tested whether factorsrelated to scientific methodology (a proposition’sreducibility and falsifiability), its intrinsic metaphysics (themateriality of the phenomena and its scope ofapplicability), and its relation to other knowledge (itscentrality to one’s other beliefs and values) influenceknowability. Across a wide range of naturalistic scientificand pseudoscientific phenomena (Studies 1 and 2), as wellas artificial stimuli (Study 3), we found that reducibilityand falsifiability have strong direct effects on knowability,that materiality and scope have strong indirect effects (viareducibility and falsifiability), and that belief and valuecentrality have inconsistent and weak effects onknowability. We conclude that people evaluate theknowability of propositions consistently with principlesproposed by epistemologists and practicing scientists

Near-Limb Zeeman and Hanle Diagnostics

"Weak" magnetic-field diagnostics in faint objects near the bright solar disk are discussed in terms of the level of non-object signatures, in particular, of the stray light in telescopes. Calculated dependencies of the stray light caused by diffraction at the 0.5-, 1.6-, and 4-meter entrance aperture are presented. The requirements for micro-roughness of refractive and reflective primary optics are compared. Several methods for reducing the stray light (the Lyot coronagraphic technique, multiple stages of apodizing in the focal and exit pupil planes, apodizing in the entrance aperture plane with a special mask), and reducing the random and systematic errors are noted. An acceptable level of stray light in telescopes is estimated for the V-profile recording with a signal-to-noise ratio greater than three. Prospects for the limb chromosphere magnetic measurements are indicated.Comment: 11 pages, 3 figure

A Fresh Look at Axions and SN 1987A

We re-examine the very stringent limits on the axion mass based on the strength and duration of the neutrino signal from SN 1987A, in the light of new measurements of the axial-vector coupling strength of nucleons, possible suppression of axion emission due to many-body effects, and additional emission processes involving pions. The suppression of axion emission due to nucleon spin fluctuations induced by many-body effects degrades previous limits by a factor of about 2. Emission processes involving thermal pions can strengthen the limits by a factor of 3-4 within a perturbative treatment that neglects saturation of nucleon spin fluctuations. Inclusion of saturation effects, however, tends to make the limits less dependent on pion abundances. The resulting axion mass limit also depends on the precise couplings of the axion and ranges from 0.5x10**(-3) eV to 6x10**(-3) eV.Comment: 32 latex pages, 13 postscript figures included, uses revtex.sty, submitted to Physical Review

Chiral symmetry and strangeness at SIS energies

In this talk we review the consequences of the chiral SU(3) symmetry for strangeness propagation in nuclear matter. Objects of crucial importance are the meson-baryon scattering amplitudes obtained within the chiral coupled-channel effective field theory. Results for antikaon and hyperon-resonance spectral functions in cold nuclear matter are presented and discussed. The importance of the Sigma(1385) resonance for the subthreshold antikaon production in heavy-ion reaction at SIS is pointed out. The in-medium properties of the latter together with an antikaon spectral function based on chiral SU(3) dynamics suggest a significant enhancement of the pi \Lambda -> bar K N reaction in nuclear matter.Comment: 10 pages, 2 figures, invited talk at Erice 200

A probabilistic threshold model: Analyzing semantic categorization data with the Rasch model

According to the Threshold Theory (Hampton, 1995, 2007) semantic categorization decisions come about through the placement of a threshold criterion along a dimension that represents items' similarity to the category representation. The adequacy of this theory is assessed by applying a formalization of the theory, known as the Rasch model (Rasch, 1960; Thissen & Steinberg, 1986), to categorization data for eight natural language categories and subjecting it to a formal test. In validating the model special care is given to its ability to account for inter- and intra-individual differences in categorization and their relationship with item typicality. Extensions of the Rasch model that can be used to uncover the nature of category representations and the sources of categorization differences are discussed

Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling

Mutations of NPHS1 or NPHS2, the genes encoding nephrin and podocin, as well as the targeted disruption of CD2-associated protein (CD2AP), lead to heavy proteinuria, suggesting that all three proteins are essential for the integrity of glomerular podocytes, the visceral glomerular epithelial cells of the kidney. It has been speculated that these proteins participate in common signaling pathways; however, it has remained unclear which signaling proteins are actually recruited by the slit diaphragm protein complex in vivo. We demonstrate that both nephrin and CD2AP interact with the p85 regulatory subunit of phosphoinositide 3-OH kinase (PI3K) in vivo, recruit PI3K to the plasma membrane, and, together with podocin, stimulate PI3K-dependent AKT signaling in podocytes. Using two-dimensional gel analysis in combination with a phosphoserine-specific antiserum, we demonstrate that the nephrin-induced AKT mediates phosphorylation of several target proteins in podocytes. One such target is Bad; its phosphorylation and inactivation by 14-3-3 protects podocytes against detachment-induced cell death, suggesting that the nephrin-CD2AP-mediated AKT activity can regulate complex biological programs. Our findings reveal a novel role for the slit diaphragm proteins nephrin, CD2AP, and podocin and demonstrate that these three proteins, in addition to their structural functions, initiate PI3K/AKT-dependent signal transduction in glomerular podocytes

Constraints on Axion Models

Two particular classes of axion models are presented, each one yielding a lower bound on the axion decay constant, based though on different considerations. In the first class only some, and not all, of the right-handed quarks have PQ charges, whereas in the second one the left-handed sector of the same quarks is taken into account as well. In the first case we find that bounds coming from astrophysics are significantly relaxed compared with those for the DFSZ. As for the second class, the astrophysical constraints proved to be less severe (with one exception), than those coming from FCNC processes.Comment: Talk given at the 5th IFT Workshop: Axions, U. of Florida, Gainesville, Florida, USA, 13-15 Mar 1998. Based on hep-ph/9708281 and hep-ph/9807363. 5pp, 1 eps fig, uses espcrc2 and graphics style

Constraints on Axion Models from K+→π+aK^+\to\pi^+ a

We explore a new class of axion models in which some, but not all, of the left-handed quarks have a Peccei-Quinn symmetry. These models are potentially afflicted by flavour changing neutral currents. We derive the bounds on the Peccei-Quinn symmetry-breaking scale from bounds on the $K^+\to \pi^+ a$ branching ratio, showing that in some cases they are even stronger than the astrophysical ones, but still not strong enough to kill off the models.Comment: 15pp RevTeX, 1 eps fig, uses graphics style. Expanded discussion on massive scalars and pseudoscalars, typos. To appear in Physical Review

NOMPC, a Member of the TRP Channel Family, Localizes to the Tubular Body and Distal Cilium of Drosophila Campaniform and Chordotonal Receptor Cells

Mechanoreception underlies the senses of touch, hearing and balance. An early event in mechanoreception is the opening of ion channels in response to mechanical force impinging on the cell. Here, we report antibody localization of NOMPC, a member of the transient receptor potential (TRP) ion channel family, to the tubular body of campaniform receptors in the halteres and to the distal regions of the cilia of chordotonal neurons in Johnston's organ, the sound-sensing organ of flies. Because NOMPC has been shown to be associated with the mechanotransduction process, our studies suggest that the transduction apparatus in both types of sensory cells is located in regions where a specialized microtubule-based cytoskeleton is in close proximity to an overlying cuticular structure. This localization suggests a transmission route of the mechanical stimulus to the cell. Furthermore, the commonality of NOMPC locations in the two structurally different receptor types suggests a conserved transduction apparatus involving both the intracellular cytoskeleton and the extracellular matrix. © 2010 Wiley-Liss, Inc

The Physics of Kondo Impurities in Graphene

This article summarizes our understanding of the Kondo effect in graphene, primarily from a theoretical perspective. We shall describe different ways to create magnetic moments in graphene, either by adatom deposition or via defects. For dilute moments, the theoretical description is in terms of effective Anderson or Kondo impurity models coupled to graphene's Dirac electrons. We shall discuss in detail the physics of these models, including their quantum phase transitions and the effect of carrier doping, and confront this with existing experimental data. Finally, we point out connections to other quantum impurity problems, e.g., in unconventional superconductors, topological insulators, and quantum spin liquids.Comment: 27 pages, 8 figs. Review article prepared for Rep. Prog. Phys. ("key issues" section). (v2) Final version as publishe