23 research outputs found
Production of a chromium Bose-Einstein condensate
The recent achievement of Bose-Einstein condensation of chromium atoms [1]
has opened longed-for experimental access to a degenerate quantum gas with
long-range and anisotropic interaction. Due to the large magnetic moment of
chromium atoms of 6 {}B, in contrast to other Bose- Einstein condensates
(BECs), magnetic dipole-dipole interaction plays an important role in a
chromium BEC. Many new physical properties of degenerate gases arising from
these magnetic forces have been predicted in the past and can now be studied
experimentally. Besides these phenomena, the large dipole moment leads to a
breakdown of standard methods for the creation of a chromium BEC. Cooling and
trapping methods had to be adapted to the special electronic structure of
chromium to reach the regime of quantum degeneracy. Some of them apply
generally to gases with large dipolar forces. We present here a detailed
discussion of the experimental techniques which are used to create a chromium
BEC and alow us to produce pure condensates with up to {} atoms in an
optical dipole trap. We also describe the methods used to determine the
trapping parameters.Comment: 17 pages, 9 figure
Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk
Breast cancer incidence and birth weight are higher among Caucasian than Asian women, and birth size has been positively associated with breast cancer risk. Pregnancy hormone levels, however, have been generally lower in Caucasian than Asian women. We studied components of the insulin-like growth factor (IGF) system in cord blood from 92 singleton babies born in Boston, USA, and 110 born in Shanghai, China, in 1994â1995. Cord blood IGF-1 was significantly higher among Caucasian compared with Chinese babies (P<10â6). The opposite was noted for IGF-2 (PâŒ10â4). IGF-1 was significantly positively associated with birth weight and birth length in Boston, but not Shanghai. In contrast, stronger positive, though statistically non-significant, associations of IGF-2 with birth size were only evident in Shanghai. The associations of birth weight and birth length were positive and significant in taller women (for IGF-1 in Boston PâŒ0.003 and 0.03, respectively; for IGF-2 in Shanghai PâŒ0.05 and âŒ0.04, respectively), among whom maternal anthropometry does not exercise strong constraints in foetal growth. The documentation of higher cord blood levels of IGF-1, a principal growth hormone that does not cross the placenta, among Caucasian than in Asian newborns is concordant with breast cancer incidence in these populations
Complexity Theory for a New Managerial Paradigm: A Research Framework
In this work, we supply a theoretical framework of how organizations
can embed complexity management and sustainable development into their policies
and actions. The proposed framework may lead to a new management paradigm,
attempting to link the main concepts of complexity theory, change management,
knowledge management, sustainable development, and cybernetics. We highlight
how the processes of organizational change have occurred as a result of the move to
adapt to the changes in the various global and international business environments
and how this transformation has led to the shift toward the present innovation
economy. We also point how organizational change needs to deal with sustainability,
so that the change may be consistent with present needs, without compromising
the future
Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis
The authors would like to thank members of OBD Reference Facility Benjamin Foulkes, Chloe Bird, Emily Corfeld and Matthew Salter for expedient processing of clinical samples on the EpiSwitchâą platform and Magdalena Jeznach and Willem Westra for help with preparation of the manuscript. The study employed samples from the SERA Biobank used with permission and approval of the SERA Approval Group. We gratefully acknowledge the invaluable contribution of the clinicians and operating team in SERA. We would also like to thank Prof. Raju Kucherlapati (Harvard Medical School), and Prof. Jane Mellor (Oxford Univ.), Prof. John OâShea (National Institute of Health) and Prof. John Isaacs (New Castle Univ.) for their independent and critical review of our study. A list of Scottish Early Rheumatoid Arthritis (SERA) inception cohort investigators is provided in Additional fle 1: Additional Note. Funding This work was funded by Oxford BioDynamics.Peer reviewedPublisher PD