10 research outputs found
Genetic Evidence for Involvement of Neuronally Expressed S1P1 Receptor in Nociceptor Sensitization and Inflammatory Pain
- Author
- AJ Pernia-Andrade
- C Forster
- Camilla Benetti
- Cristina E. Constantin
- DJ Cavanaugh
- E Jo
- G van Echten-Deckert
- H Meng
- H Schmidt
- I Dittert
- Ian L. Gibbins
- J Rivera
- J Scholz
- J Vandesompele
- JM Braz
- JS Smolen
- K Hargreaves
- K Mizugishi
- K Takabe
- KA Park
- KB Hagen
- Kenji Hashimoto
- KJ Livak
- M Andratsch
- M Ishii
- M Kitano
- M Koltzenburg
- M Kress
- M Maceyka
- M Zwick
- Manfred Andratsch
- Maria Camprubí-Robles
- ME Goldstein
- MH Graler
- Michael G. Leitner
- Michaela Kress
- MJ Caterina
- ML Allende
- N Agarwal
- N Agarwal
- N Murata
- NM Breese
- Norbert Mair
- O Coste
- O Coste
- O Linhart
- O Obreja
- O Obreja
- P Bandhuvula
- P Mitra
- PH Lindfors
- Q Deng
- R Alemany
- R Ohkawa
- R Rivera
- Rainer V. Haberberger
- Rohini Kuner
- S Dirajlal
- S Pyne
- S Siehler
- S Spiegel
- S Tsunemi
- SE Alvarez
- Serena Quarta
- SG Bourgoin
- SH Le
- SM Hammad
- SP Hunt
- TA Taha
- V Saravanan
- Wolfgang Biasio
- WQ Lai
- Y Liu
- YA Hannun
- YH Zhang
- YH Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Sphingosine-1-phosphate (S1P) is a key regulator of immune response. Immune cells, epithelia and blood cells generate high levels of S1P in inflamed tissue. However, it is not known if S1P acts on the endings of nociceptive neurons, thereby contributing to the generation of inflammatory pain. We found that the S1P1 receptor for S1P is expressed in subpopulations of sensory neurons including nociceptors. Both S1P and agonists at the S1P1 receptor induced hypersensitivity to noxious thermal stimulation in vitro and in vivo. S1P-induced hypersensitivity was strongly attenuated in mice lacking TRPV1 channels. S1P and inflammation-induced hypersensitivity was significantly reduced in mice with a conditional nociceptor-specific deletion of the S1P1 receptor. Our data show that neuronally expressed S1P1 receptors play a significant role in regulating nociceptor function and that S1P/S1P1 signaling may be a key player in the onset of thermal hypersensitivity and hyperalgesia associated with inflammation
Introduction
- Author
- A Mathios
- AM Spence
- BL Egan
- D Sappington
- DP Baron
- DR Patrick
- EE Bailey
- EE Bailey
- EE Zajac
- F Ramsey
- GR Faulhaber
- H Averch
- H Liebenstein
- HK Face
- I Vogelsang
- J Griffin
- J Haring
- J Vickers
- JT Wenders
- KB Levitz
- L Courville
- LJ Mirman
- LL Johnson
- M Harris
- MB Goldman
- National Telecommunications and Information Administration
- Office of Telecommunications
- PB Linhart
- PS Dasgupta
- R Schmalensee
- RG Noll
- RM Spann
- S Atkinson
- S Littlechild
- S Wellisz
- SB Megdal
- SK Bhattacharyya
- VK Smith
- WJ Baumol
- WJ Baumol
- YK Ng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1991
- Field of study
Detained Male Adolescent Offender’s Emotional, Physical and Sexual Maltreatment Profiles and Their Associations to Psychiatric Disorders and Criminal Behaviors
- Author
- AJ Stewart
- B Plattner
- B Plattner
- Belinda Plattner
- C Armour
- CC Cottle
- CD Scher
- Cornelia Bessler
- CP Carr
- DA Linzer
- DC King
- DJ Higgins
- DP Bernstein
- DP Bernstein
- DV Sheehan
- E Moore
- HA Turner
- Hans-Christoph Steinhausen
- HL MacMillan
- J Huemer
- JD Ford
- JD Ford
- JD Ford
- JD Ford
- JP Ryan
- JV Penn
- K Bader
- K Hermenauab
- KA Pavlov
- KB Nooner
- KC Pears
- KL Nylund
- KM Abram
- KR Merikangas
- KW Spertus
- Leonhard Thun-Hohenstein
- M Forsman
- M Shevlin
- Marcel Aebi
- MC Seto
- MG Maxfield
- MK Krischer
- MR McCart
- O Colins
- PE Mullen
- R Borum
- R Dembo
- R Development Core Team
- R Prentky
- RF Hanson
- S Fazel
- S Rosenman
- SP Becker
- SP Becker
- SR Berzenski
- Susanne Linhart
- T Ford
- TM Achenbach
- VJ Edwards
- Y Benjamini
- ZW Adams
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Infiltrative/storage cardiomyopathies: Clinical assessment and imaging in diagnosis and patient management
- Author
- A Dürr
- A Jaccard
- A Linhart
- A Linhart
- A Lorber
- A Uemura
- AL Klein
- AL Klein
- AL Klein
- AT Ploeg van der
- AV Hoffbrand
- B Guertl
- B Murtagh
- B Ng
- B Radulescu
- B Sachdev
- BA Austin
- BA Mc Ardle
- BJ Maron
- BJ Maron
- BJ Sun
- BK Schaadt
- C Aggeli
- C Aprile
- C Chapelon-Abric
- C Gruner
- C Kampmann
- C Rapezzi
- C Rapezzi
- C Rapezzi
- CC Quarta
- CE Miguel
- D Bellavia
- D Bellavia
- D Guludec Le
- D Holmgren
- D Liu
- D Miani
- D Mohty
- D Morvan
- D Phelan
- D Piotrowska-Kownacka
- D Rigante
- DA Brenner
- DM Sado
- DP Dutka
- DT Kremastinos
- E Fabris
- E Perugini
- E Picano
- ET Alboliras
- F Barbey
- F Cappelli
- F Minutoli
- F Weidemann
- F Weidemann
- F Weidemann
- FL Ruberg
- G Antoni
- G Finocchiaro
- G Finocchiaro
- G Galati
- G Merlini
- G Mundigler
- G Nucifora
- G Youssef
- GH Oliveira
- GY Lee
- H Baccouche
- H Tada
- H Yamagishi
- IS Syed
- J Alexander
- J Koyama
- J Koyama
- J Kramer
- JB Selvanayagam
- JB Seward
- JC Moon
- JC Wood
- JD Carroll
- JE Rahman
- JH Dangel
- JP Smedema
- JP Sun
- JS Child
- JS Kim
- JS Shah
- K Karp
- K Kodama
- K Okayama
- K Saito
- KB Shah
- KJ Silverman
- L Driessche Van
- L Monserrat
- LJ Anderson
- LJ Anderson
- LJ Olson
- LT Cooper
- M Arad
- M Beer
- M Calcagnino
- M Eguchi
- M Hongo
- M Hongo
- M Leone
- M Niemann
- M Niemann
- M Niemann
- M Pieroni
- M Pieroni
- M Puille
- M Sebastiani
- M Tanaka
- MA Seliem
- MGD Bates
- MJ Danon
- MJ Garcia
- MR Patel
- MR Schulze
- N Delahaye
- N Funabashi
- N Sharma
- N Tahara
- O Detry
- P Charron
- P Cochat
- P Elliott
- P Kuan
- P Laforêt
- P Palka
- P Palka
- P Suksaranjit
- PD Jensen
- R Anan
- R Bargout
- R Blankstein
- R Fattori
- R Schiffmann
- RA Kyle
- RA Kyle
- RH Falk
- RH Falk
- RJ Kalliokoski
- RP Baughman
- RT Murphy
- S Bokhari
- S Chen
- S Ghio
- S Han
- S Ishimaru
- S Koeppe
- S Vélez-Roa
- SB Tsai
- SJ Buss
- SM Banypersad
- SM Butman
- SW Dubrey
- SW Dubrey
- T Hazirolan
- T Miszalski-Jamka
- T Miszalski-Jamka
- T Palecek
- TD Karamitsos
- WC Roberts
- WS Colucci
- Y Satoh
- Y Shapir
- YA Zarate
- YH Chien
- Z Yousef
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/03/2017
- Field of study
10non/anonenoneMoretti, Michele; Fabris, Enrico; Finocchiaro, Gherardo; Pinamonti, Bruno; Abate, Elena; Vitrella, Giancarlo; Merlo, Marco; Brun, Francesca; Pagnan, Lorenzo; Sinagra, GianfrancoMoretti, Michele; Fabris, Enrico; Finocchiaro, Gherardo; Pinamonti, Bruno; Abate, Elena; Vitrella, Giancarlo; Merlo, Marco; Brun, Francesca; Pagnan, Lorenzo; Sinagra, Gianfranc
Ethical dilemmas concerning autonomy when persons with dementia wish to live at home: a qualitative, hermeneutic study
- Author
- A Barkay
- A Gallagher
- A Jaworska
- A Jones
- A Mol
- A Norberg
- AA Ryan
- AJ Davies
- AJ Vetlesen
- AK Helgesen
- B Dale
- B Dale
- B McCormack
- BJ Collopy
- C Clarke
- C Edwards
- C Edwards
- C Gastmans
- C Gilligan
- CL McWilliam
- CL Twigger-Ross
- D Edvardsson
- D Fetherstonhaugh
- D Pullman
- D Silverman
- DJ Lyttle
- GJ Agich
- H Gilmour
- H Lillehammer
- H Tuokko
- H Wilkensen
- HJ Gadamer
- I Randers
- J Dewing
- J Hays
- J Moriarity
- J Rees
- JC Hughes
- JC Tronto
- JHT Karlawish
- K Lothian
- K Theurer
- K Zingmark
- Kari Lislerud Smebye
- KB Hirschman
- Knut Engedal
- KW Ruyter
- L Witt De
- L Witt De
- LC Manzo
- LW Sørbye
- M Lowe
- M Verkerk
- Marit Kirkevold
- MC Tierney
- MI Linhart
- N Nodding
- NK Denzin
- Patton M Q
- PB Harris
- R Dworkin
- R Dworkin
- R Suhonen
- RK Yin
- S Holm
- S Thorne
- SO Daatland
- SR Kaufman
- T Kitwood
- T Persson
- TL Beauchamp
- VWC Lui
- Å Slettebø
- Ø Kirkevold
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pre-spillover Prevention of Emerging Zoonotic Diseases: What Are the Targets and What Are the Tools?
- Author
- A Abbott
- A Dobson
- A Fornes
- A James
- A Nalca
- A Stegeman
- A Thier
- AB Thiermann
- ADME Osterhaus
- Advisory Committee on Immunization Practices
- AK Delsink
- AM Kilpatrick
- AP Travassos da Rosa
- APHIS Wildlife Services Factsheet
- AR Fooks
- AR Gould
- B Brochier
- B Brochier
- B Hjelle
- B Hjelle
- B Kermode-Scott
- BC La
- BE Cunha
- BH Hahn
- BJ Lamphear
- C Apetrei
- C Fraser
- C Hall
- C Sillero-Zubiri
- C Zepeda
- CA Donnelly
- CA Hanlon
- CA Hanlon
- CA Olson
- CA Russell
- CA Russell
- CD Blair
- CD Macinnes
- CD Paddock
- CE Mills
- CE Rupprecht
- CE Rupprecht
- CE Rupprecht
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- CH Calisher
- CJ Luke
- CJ Wu
- CM Barker
- CO Tacket
- CS Kolar
- CT Sabeta
- CW Lee
- D Bell
- D Calavas
- D Castle
- D Chen
- D Heim
- D Slate
- DA Talan
- DE Roscoe
- DE Stallknecht
- DE Swayne
- DG Constantine
- DJ Leprince
- DL Heymann
- DL Heymann
- DL Smith
- DM Custer
- DS Melville
- DT Haydon
- DW Hayne
- E Check
- E Gormley
- EC Claas
- ED Moreira Jr
- EM Leroy
- EM Leroy
- ER Gordon
- ER Gordon
- ES Williams
- F Bourliere
- F Mayen
- F Mostashari
- FA Leighton
- G Wobeser
- G Xu
- GA Mount
- GA Polis
- GC Fraser
- GC Smith
- GE Glass
- GE Glass
- GE Glass
- GF Gensini
- GH Olsen
- GJ Chang
- GJ Moran
- GJ Weiler
- GS Birkhead
- H Chen
- H Field
- H Furguson
- HD Song
- HE Field
- HG Steelman
- J Guarner
- J Heerden Van
- J Martinez-Burnes
- J Muller
- J Overbeck Von
- J Parry
- J Shaman
- J Speakman
- J Tappero
- J Watts
- J Watts
- J Zhuang
- JA Kellar
- JD Verlinde
- JE Childs
- JE Childs
- JE Childs
- JE Childs
- JE Childs
- JE Childs
- JE Childs
- JE Childs
- JE Childs
- JE Whitby
- JF Day
- JF Kirkpatrick
- JG Debbie
- JI Tsao
- JJ Root
- JL Rasgon
- JM Griffin
- JM Lockhart
- JM Lockhart
- JN Mills
- JN Mills
- JN Mills
- JN Mills
- JP Duff
- JR Stephenson
- JS Duchin
- JS Mencher
- JS Oxford
- JS Smith
- JS Tam
- JW Buehler
- JW Krebs
- JW LeDuc
- K Ahmad
- K Halpin
- K LoGiudice
- K Stohr
- KB Chua
- KE Olson
- KF Shortridge
- KL Warfield
- KM Sturm-Ramirez
- KS Li
- L Campitelli
- L Yiming
- LA Miller
- LA Selvey
- LE Real
- LJ King
- M Eidson
- M Eidson
- M Eidson
- M Enserink
- M Larkin
- M Pastor-Anglada
- M Stefanak
- M Theiler
- MA Guerra
- MA Marco De
- MC Garvin
- MD Salman
- MD Salman
- ME Jones
- ME Summa
- ME Torrence
- ME Woolhouse
- MFA Aubert
- MG Fearneyhough
- MH Chew
- MJ Coyne
- MJ Turell
- ML Wilson
- N Duzgunes
- N Komar
- N Ueba
- N Zhong
- ND Wolfe
- NI Paton
- NJ Cox
- O Tomori
- P Daszak
- P Foroutan
- PC White
- PD Crook
- PD Walsh
- PK Uppal
- PM Kitala
- PT Hooper
- PT Hooper
- PW Kat
- PW Lurz
- R Bradley
- R Burrows
- RA Fayrer-Hosken
- RA Fouchier
- RB Tesh
- RC Chapman
- RC Rosatte
- RD Slemons
- RD Thompson
- RF Crespo
- RG Webster
- RJ Cox
- RJ Delahay
- RJ Huebner
- RJ Huebner
- RL Moolenaar
- RM Anderson
- RM Anderson
- RM Bennett
- RS Lanciotti
- RS Ostfeld
- RS Ostfeld
- RT Bryan
- S Cleaveland
- S Krauss
- SB Linhart
- SB Linhart
- SB Thacker
- SC Farry
- SC Gascoyne
- SC Gascoyne
- SC Guptill
- SC Weaver
- SE Little
- SE Shaw
- SK Lam
- SL Messenger
- SM Teutsch
- ST Nichol
- T Koss
- T Mörner
- T Mörner
- TE Rocke
- TF Hatchette
- TG Ksiazek
- TH Tran
- TJ Daniels
- TJ Myers
- TJ Roper
- TL Yates
- TM Ellis
- TM Ellis
- TM Tumpey
- TP Monath
- TW Scott
- VA Ferro
- VF Nettles
- W Li
- W Li
- WB Ballard
- WG Winkler
- WI Butler Jr
- WR Davidson
- X Lu
- Y Guan
- Y Guan
- Y Guan
- Y Guan
- Y Guan
- Y Guan
- Y Huang
- Y Matsuoka
- YK Choi
- YL Lau
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
The role of echocardiographic deformation imaging in hypertrophic myopathies
- Author
- A Baltabaeva
- A D'Andrea
- A D'Andrea
- A Ganau
- A Linhart
- A Marciniak
- A Marciniak
- A Mehta
- A Van Der Toorn
- A. J. Teske
- AA Geisterfer-Lowrance
- AC Ng
- AK Rutz
- AL Klein
- AM Maceira
- AO Conrady
- B Bijnens
- B Ng
- B Schwartzkopff
- Bart H. Bijnens
- BH Bijnens
- BJ Maron
- BJ Maron
- BJ Maron
- BJ Maron
- BM Pluim
- BM van Dalen
- C Rajiv
- CG Blomqvist
- CM Eng
- CM Eng
- D Bellavia
- D Vinereanu
- DA Brenner
- DP Dutka
- E Abergel
- E Donal
- E Eroglu
- EP Hoffman
- F Cappelli
- F Jamal
- F Weidemann
- F Weidemann
- F Weidemann
- F Weidemann
- F Weidemann
- F Weidemann
- F Weidemann
- F Weidemann
- G Buyse
- G Derumeaux
- G Perseghin
- G Piella
- G Shimizu
- George R. Sutherland
- GP Aurigemma
- GR Sutherland
- H Ardehali
- H Niimura
- H Thibault
- H Yang
- I Medugorac
- J Bogaert
- J Chan
- J Ganame
- J Korinek
- J Koyama
- J Koyama
- J Koyama
- J Lumens
- J Morganroth
- JC Moon
- JC Moon
- JJ Sandstede
- JL Bradley
- JM Strotmann
- JP Sun
- JR Wright
- JS Child
- JU Voigt
- K Saito
- K Serri
- KA Connelly
- KB Shah
- L Herbots
- L Mertens
- LC Palmon
- LH Opie
- Lisa J. Anderson
- LM Shapiro
- M Beer
- M Hatford
- M Kowalski
- M Kowalski
- M Pieroni
- M Przewlocka-Kosmala
- M Stuber
- MA Robbins
- Maja Cikes
- MK Heng
- OA Breithardt
- P Caso
- P Charron
- P Charron
- P Claus
- P Elliott
- P Elliott
- P Palka
- P Richardson
- P Rustin
- P Westermark
- PJ Meikle
- PP Sengupta
- PP Sengupta
- R Beyar
- R Hewer
- RA Greenbaum
- RA Kyle
- RH Falk
- RL Moore
- RM Lang
- S Carasso
- S Hein
- S Langeland
- S Orlando
- S Severino
- SA Chang
- SF Nagueh
- SH Poulsen
- SJ Dong
- SJ Park
- SW Dubrey
- T Ito
- TS Kato
- TS Kato
- V Richand
- W Grossman
- W Kosmala
- WD Biggar
- WJ Karlon
- YJ Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Reactive Carbonyl Species Scavengers—Novel Therapeutic Approaches for Chronic Diseases
- Author
- A Boldyrev
- A Kheradmand
- A Kirabo
- AF Aydin
- AJ Townsend
- AMD Watson
- AN Fonteh
- AR Hipkiss
- AR Hipkiss
- B Courten de
- B Gualano
- BE Brown
- BI Freedman
- C Lambert
- C Lombardi
- C-H Wang
- CD Aluise
- CD Charvet
- CJ Brame
- CK Davis
- D Foreman
- D Rindgen
- D Sullivan
- D Thotala
- DE Maessen
- E Brinkmann
- E Brinkmann
- E DiFranco
- EJ Carrier
- EJ Lewis
- EM Yazlovitskaya
- ER Yilmaz
- F Chronidou
- H Esterbauer
- H Yan
- I Allaman
- I Chipinda
- I Everaert
- I Triantafyllidis
- I Zagol-Ikapite
- I Zagol-Ikapitte
- I Zagol-Ikapitte
- I Zagol-Ikapitte
- J Gu
- J Hayslip
- J Min
- J Wu
- J Zhao
- JF Stevens
- JJ Galligan
- JM Vose
- JN Baraniuk
- JN Pearson
- JP Kehrer
- JR Kouvaris
- K Amirshahrokhi
- K Fukuda
- K Itakura
- K Sakae
- K Uchida
- K Uchida
- KA Tacka
- KA Zemski Berry
- KB Linhart
- KS Chio
- L Aerts
- L Guo
- L Guo
- L Kabasakal
- L Regazzoni
- LD Marchette
- LJ Marnett
- LM Sayre
- M Colzani
- M Corradi
- M Frischmann
- M Fukuoka
- M Guichardant
- M Jalali
- M Orioli
- M Sakurai
- M Tanimoto
- MA Babizhayev
- MA Babizhayev
- ME Williams
- MR Brodeur
- MR McCall
- MSS Alhamdani
- MU Ahmed
- N Brock
- N Rabbani
- N Rabbani
- N Vidal
- NI Skrypnyk
- O Boutaud
- OA Barski
- ON Bae
- P Fuchs
- PA Boyden
- PJ Quinn
- Q Zhu
- R Liu
- R Mastrocola
- R Zieba
- RC Harris
- RG Salomon
- RG Salomon
- RG Salomon
- RH Nagaraj
- S Menini
- S Menini
- S Menini
- S Zhou
- SC Shuck
- SH Lee
- SS Davies
- SS Davies
- SS Davies
- T Arai
- T Nagasawa
- T Nakajima
- T Oe
- TN Sidorova
- TP Degenhardt
- TW Lo
- U Cornelli
- U Ludwig
- V Amarnath
- V Amarnath
- V Peters
- V Peters
- VS Bispo
- W Bi
- W Cao
- W Liu
- WA Pryor
- WH Zhang
- WK Bolton
- X Li
- X Zhang
- Y Liu
- Y Yang
- YT Lee
- Z Dong
- ZY Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
- Author
- A Amabile
- A Di Ruscio
- A Dong
- A Jeltsch
- A Jeltsch
- A Miura
- A Molaro
- A Termanis
- A Timinskas
- A Tsumura
- A Vojta
- A Zemach
- AA Aravin
- AD Riggs
- AJ Bewick
- AK Maunakea
- AM Deaton
- AY Maslov
- BH Ramsahoye
- C Falckenhayn
- C Holz-Schietinger
- C Legrand
- C Stresemann
- C Wijmenga
- CA Gifford
- CE Duymich
- CG Spruijt
- CJ Klein
- CL Keown
- CP Walsh
- CR Wilkinson
- D Bourc'his
- D Bourc'his
- D Jia
- D Schubeler
- DA Russler-Germain
- DH Spencer
- E Li
- F Lu
- F Lyko
- F Neri
- F Sorm
- F Tuorto
- F Tuorto
- Frank Lyko
- G Fan
- G Raddatz
- G Raddatz
- G Zhang
- GA Challen
- GC Hon
- GL Xu
- H Hashimoto
- H Heyn
- H Lei
- H Leonhardt
- H Sasaki
- H Wu
- H Zhu
- HG Linhart
- HW Gabel
- J Arand
- J Baets
- J Barau
- J Du
- J He
- J Kiani
- J Liao
- J Liu
- J Posfai
- J Ren
- J Sharif
- J Song
- J Wang
- JA Law
- JA Yoder
- JC Wu
- JC Wu
- JT Huff
- K Dennis
- K Tatton-Brown
- KA Gray
- KB Chiappinelli
- KD Rasmussen
- KD Robertson
- KR Ostler
- L Chen
- L Ponger
- L Rinaldi
- M Bostick
- M Boulard
- M Ehrlich
- M Iurlaro
- M Iurlaro
- M Jeong
- M Morselli
- M Okano
- M Okano
- M Okano
- M Schaefer
- MA Sanchez-Romero
- MG Goll
- MG Goll
- MJ Koziol
- MR Rountree
- N Ahuja
- P Stepper
- PA Jones
- PA Jones
- PA Jones
- PE Thijssen
- PO Esteve
- PO Esteve
- PW Laird
- Q Du
- R Bonasio
- R Deplus
- R Holliday
- R Kucharski
- R Lister
- R Lister
- R Shanmugam
- RJ Gibbons
- RJ Klose
- RL Tiedemann
- RR Dev
- RS Hansen
- S Alvarado
- S Domcke
- S Feng
- S Henikoff
- S Klimasauskas
- SA Manakov
- SB Baylin
- SJ Kim
- SK Ooi
- T Baubec
- T Bestor
- T Chen
- TH Bestor
- TJ Ley
- TP Jurkowski
- TP Jurkowski
- U Aapola
- W Reik
- W Xie
- X Cao
- X Guo
- X Zhang
- XS Liu
- Y Bergman
- Y Gruenbaum
- Y Yin
- Z Durdevic
- Z Sun
- ZD Smith
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
- Abramson B
- Abrantes J
- Achilli A
- Adams A
- Adams K
- Adamus J
- Addington J
- Adgey A
- Adjei A
- Agarwal J
- Aggarwal A
- Aggarwal K
- Aggarwal R
- Agocha A
- Agraou B
- Aguirre O
- Ahmed A
- Ahmed O
- Ahsan A
- Airaksinen J
- Airoldi F
- Aji J
- Akkad H
- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
- Albirini A
- Albuquerque A
- Albuquerque D
- Alcasena S
- Alexander J
- Alfonso F
- Ali MI
- Alings MA
- Allall O
- Allen J
- Allen RP
- Allred S
- Almeira AS
- Alonso L
- Alsagheer S
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- Altschuller A
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- Alvarez J
- Alvarez Y
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- Amidon T
- Amos M
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- Artaecheverria J
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- Walters B
- Wang Y
- Wanitschek M
- Ward P
- Ward U
- Warlits B
- Warnica J
- Washam M
- Watkins K
- Watson R
- Wead J
- Wechselberger T
- Weeks A
- Weidinger F
- Weihs W
- Weil J
- Weiss A
- Weller C
- Werner G
- Werter CJ
- Wertheimer J
- Wesley D
- Westecott B
- Westenburg J
- Wheeler M
- Wheeler M
- Whitaker T
- Whitcomb C
- White D
- White H
- White H
- White J
- White J
- White J
- White Jennifer A.
- Wiegman P
- Wiemer M
- Wikström P
- Wilhelm J
- Wilhelm M
- Wilks J
- Willems FF
- Williams P
- Williams S
- Williams V
- Wilson S
- Wilson V
- Wilson V
- Winestock J
- Winther-Friis B
- Wirtemburg P
- Wiseman A
- Withagen AJ
- Witsaman S
- Witt N
- Witzling V
- Wiviott Stephen D.
- Wohns D
- Wojciechowska C
- Wong A
- Wong B
- Wong G
- Wong S
- Wong Y
- Woodhead G
- Worner F
- Worthley S
- Wright L
- Wright T
- Wright W
- Wrzosek B
- Wu C
- Wu L
- Wu W
- Wyman P
- Yalcin R
- Yanez L
- Yedinak S
- Yeh H
- Yen M
- Yeo D
- Yigit Z
- Yildirir A
- Yildiz Z
- Yoon J
- Yoon M
- Young C
- Yovaniniz P
- Yu C
- Yu W
- Yuval R
- Zahn R
- Zakhary B
- Zaluska R
- Zambahari R
- Zanini R
- Zanini R
- Zanolin D
- Zapata M
- Zarandon R
- Zeiher A
- Zeltser D
- Zeman K
- Zemberova A
- Zemour G
- Zender H
- Zeymer U
- Zhukova Y
- Ziegler B
- Zimlichman R
- Zimmerman T
- Zimmermann R
- Zingarelli A
- Zirkle J
- Zucchetti C
- Zughaib M
- Zuidgeest JA
- Zuppiroli A
- Zwart PA
- Zweiker R
- Ångman K
- Édes I
- Östberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit