A Molecular Orbital Study of the Reduction Mechanism of Monoterpene, p-Mentha -1,3-dien-7-al, with Sodium in Aqueous Ammonia

水溶液中における金属ナトリウムによるテルペン類の還元法は、飽和、不飽和ケトンおよびアルデヒド類に広く適用でき、優れた立体選択性のあることを報告してきたが、還元機構は未だ確立されていない。今回、一つの試みとしてラジカル反応の指標によく用いられる自由原子価指数をHMO法で計算し、実験データとの比較から本還元がラジカル的に進行する裏付けとなる知見を得ることが出来た。Article信州大学農学部紀要 9(2): 83-90(1972)departmental bulletin pape

Activity of Naringinase in the Extracts from Citrus unshiu waste Treated with Brewer's Yeasts and Their Inhibitory Effects on Angiotensin Converting Enzyme

Naringinase activity and inhibitory potency against Angiotensin- converting enzyme were tested in the extract from Citrus unshiu waste treated with various brewer's yeasts. Naringinase activity in the yeasts tested was much smaller than that in some fungi. It was, however, proved that if an appropriate incubation method is adopted, analysis method is effective for this system. Inhibitory effect in the extract, on the contrary, was shown being positive in almost all strains tested. These results suggest that this approach will be a promising method to make a component of functional foods.Article信州大学農学部紀要 25(1): 37-44(1988)departmental bulletin pape

Protocatechuate 3, 4-Dioxygenase from Pseudomonas sp. : Partial Purification and Some Properties

Article信州大学農学部紀要 23(1): 43-49(1986)departmental bulletin pape

Synthesis of Butyl 1-p-Menthene-3-A.zido-4-Hydroxy-7-Carboxylate, the Synthetic Intermediate of Statine Analogue

Protease inhibitor, pepstatin is a pentapeptide which involves two unusual amino acid, statine (3S-hydroxy-4S-amino-6-methylheptanoic acid (I)). Pepstatin is known to inhibit renin in the hypertensive renin-angiotensin system and shown to suppress blood pressure strongly. The present paper deals with the simple and convenient synthesis of butyl 1-p-menthen-3-azido-4-hydroxy-7-carboxy late (III) in which III is one of the important intermediate leading to the isosteric isomer of statin, namely, p-menthan-3-amino-2-hydroxy-7-carboxylic acid (II). Further, the acid-catalysed isomerization is also discussed.Article信州大学農学部紀要 24(2): 141-146(1988)departmental bulletin pape

Studies on Pheromones of Female Eri-Silk Moth, II. Preparation of Some Conjugated C₁₆-C₁₇ Alkadienals and Comparison of Them with the Pheromone by GLC

Article信州大学農学部紀要 20(1): 133-142(1983)departmental bulletin pape

Studies on Pheromones of Female Eri-Silk Moth, I. Preparation of C₆-C₁₁ 2-Alkenyl Triphenyiphosphonium Bromides

Article信州大学農学部紀要 20(1): 127-132(1983)departmental bulletin pape

Activities of Angiotensin-I Converting Enzyme Inhibition in Proteolytic Hydrolyzate of Food Proteins: In View of Development of Physiologically Functional Peptides

ACE inhibitory activity in hydrolyzate of food proteins treated by some proteases was tested. The protein from soybean, when it was hydrolyzed by proteases, had larger ACE inhibitory activity, especially at neutral pH. At lower and higher pH all hydrolyzate did not show high ACE inhibitory activity contrary to our expectations. Without treatment of protease, on the contrary, soybean protein had lower ACE inhibitory activity than those of wheat and corn.Article信州大学農学部紀要 26(1・2): 13-20(1990)departmental bulletin pape

Partial Hydrolysis of Oligopeptide, I. -Partial Hydrolysis of Two Tetrapeptides and Their Separation Patterns of Fragments in Gas Chromatography

Article信州大学農学部紀要 18(2): 183-190(1981)departmental bulletin pape

Studies on Pheromones of Female Eri-Silk Moth, III. Synthesis of (6Z, 11Z)-6,11-Hexadecadienal and Its Activity as Pheromone Mimics toward Male Eri-Silk Moth

Article信州大学農学部紀要 20(2): 213-218(1983)departmental bulletin pape

Synthesis of Some New 2-Tetrafluoroethyl-pseudooxazolones-(5) from the Tfp-Amino Acids

我々のグループでペプチド合成における新しいN-保護基を開発中であるが，その一環として既にTfp(テトラフロロプロピオニル)基の性質およびその応用を報告し，ラセミ化を伴う際の反応中間物であるシュードオキサゾロンを単離，同定した。今回，オキサゾロンにL-アミノ酸又はジペプチドを作用させる場合の不斉誘導因子を究明する目的で一連のオキキゾロンをTfp-アミノ酸から系統的に合成し，それらの構造決定を行なった。合成されたオキサゾロンは4位の置換基がメチル，エチル，n-プロピル，n-ブチル，イソブチル，ベンジルの各物質であり，それらはいずれもシュード型オキサゾロンであることを確認した。Article信州大学農学部紀要 11(1): 87-92(1974)departmental bulletin pape