Okul çağındaki çocuklarda vitamin B12, folat ve demir eksikliği prevalansının değerlendirilmesi

Amaç: Demir, vitamin B12 ve folat eksikliği tüm dünyada özellikle çocuklarda sık görülen mikrobesineksikliklerindendir. Demir, vitamin B12 ve folat birçok enzimin yapısına girerek vücut metabolizması,hücre bölünme ve farklılaşması, immun sistemin düzenlenmesi, kemik gelişimi, algılama ve zekâfonksiyonunda rol oynamaktadır. Çalışmada, çocuklarda serum demir, vitamin B12 ve folat eksikliğiprevalansını araştırdık.Gereç ve Yöntem: Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesi Hastanesi Genel ÇocukPolikliniği’ne başvuran 6-14 yaş arası toplam 392 çocukta serum demir düzeyi, demir bağlamakapasitesi, ferritin, vitamin B12, folat düzeyi ve tam kan sayımı çalışıldı. Sosyoekonomik düzey,beslenme şekli, fiziksel gelişimi, eğitim düzeyi gibi çeşitli parametreleri içeren anket düzenlendi.Bulgular: Çalışmamız 223 kız, 169 erkek toplam 392 çocukla yapıldı. Olguların %60,5’inde demireksikliği (DE), %33,4’ünde vitamin B12 eksikliği, %7,6’sında folat eksikliği ve yetersizliği saptandı.Olgular 6-10 yaş (n=211) ve 11-14 yaş (n=181) olarak iki grupta incelendiğinde vitamin B12 eksikliğiningörülme sıklığında adölesanlarda istatistiksel olarak anlamlı fark saptandı (p<0,001). DE olan olguların%10,2’sinde folat yetersizliği ve eksikliği saptanırken, DE olmayanlarda folat yetersizliği ve eksikliği%3,9 oranında bulundu. Bu fark istatistiksel olarak anlamlı idi (p=0,037).Sonuç: Nutrisyonel eksikliklerin her zaman klinik yakınmaları olmayabilir. Çalışmamızda çocuklardabu eksikliklerin yaygın olduğunu gördük. Amaç klinik bulgular ortaya çıkmadan eksiklikleri saptamakolmalıdır.Aim: Iron, vitamin B12 and folate deficiency are common micronutrient deficiencies all over the world especially in children. Iron, vitamin B12 and folate play a role in body metabolism, cell division and differentiation, regulation of the immune system, bone development, perception and intelligence function by entering the structure of many enzymes. In the study, we investigated the prevalence of serum iron, vitamin B12 and folate deficiency in children. Materials and Methods: Serum iron level, iron binding capacity, ferritin, vitamin B12, folate level and complete blood count were studied in a total of 392 children aged 6-14 years who applied to the General Pediatric Polyclinic of Zonguldak Bulent Ecevit University Medical Faculty Hospital. A questionnaire including various parameters such as socioeconomic level, diet, physical development, education level was organized. Results: Our study was done with 223 girls and 169 boys, a total of 392 children. Iron deficiency (ID) was found in 60.5% of the cases, vitamin B12 deficiency in 33.4%, folate deficiency and insufficiency in 7.6%. When the cases were examined in two groups as 6-10 years (n = 211) and 11-14 years (n = 181), a statistically significant difference was found in the prevalence of vitamin B12 deficiency in adolescents (p <0.001). While folate deficiency and insufficiency were found in 10.2% of the cases with ID, it was found at a rate of 3.9% in those without ID. This difference was statistically significant (p = 0.037). Conclusion: Nutritional deficiencies may not always have clinical complaints. In our study, we found that these deficiencies were common in children. The aim should be to detect deficiencies before clinical findings appear

Comparison of Hemogram Parameters in Febrile Seizures Types

Aim: Febrile seizures (FS) are among the most common neurological emergencies duringchildhood and clinically classified into two types, being simple febrile seizures (SFS) andcomplicated febrile seizures (CFS). The differentiation between FS types is important, in thatthey are associated with different morbidity and mortality risks and it is based on the clinicalcharacteristics of each seizure, however there is currently no laboratory test that can guide thisdifferentiation. In this study, the relationship between FS types and hemogram parameters wasevaluated and potential use of these parameters in differential diagnosis was investigated.Material and Methods: This retrospective study included a total of 133 patients whose firstFS met the criteria of an FS, and whose hemogram results were available. The AmericanAcademy of Pediatrics criteria were used to confirm the diagnosis. The patients were dividedinto two groups as SFS and CFS.Results: Hemoglobin (Hb), hematocrit (HCT), mean platelet volume (MPV), neutrophillymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) differed significantly betweentwo groups (p<0.001, p=0.002, p=0.033, p<0.001, p<0.001, respectively), while no significantdifference was identified in total blood count parameters. Moreover, MPV was significantlyhigher in CFS group than in SFS group.Conclusion: This is one of the few studies investigating the potential relationship betweenhemogram parameters and FS types in children. We believe that, although they do not ensurea clear differentiation, Hb, MPV, NLR and PLR may be useful to clinicians in differentiatingbetween FS types, particularly in patients with an unclear seizure history

A case of acute myeloid leukemia presenting with deep venous thrombosis

Çocuklarda görülen venöz tromboz çoğunlukla kateterizasyon, enfeksiyöz hastalıklar, kalıtsal trombofili ve metabolik hastalıklar gibi altta yatan bir risk faktörü ile ilişkilidir. Kanser çocukluk çağında görülen primer venöz trombozların önemli bir nedenidir ve çocukluk çağı venöz tromboz olgularının beşte birinden sorumludur. Bu yazıda ilk başvuru bulgusu derin ven trombozu olan ve takibinde akut myeloid lösemi (AML) tanısı konulan 13 yaşında kız hasta sunulmuştur.Deep venous thrombosis is mostly associated with an underlying risk factor such as venous catheter, infectious diseases, hereditary thrombophilia and metabolic diseases. Cancer is one of the most common primary disorders in pediatric venous thrombosis, accounting for one-fifth of children with thrombotic events. Here we report a 13-year-old female patient who is diagnosed as deep vein thrombosis due to acute myeloid leukemia

Comparison of Hemogram Parameters in Febrile Seizures Types

Aim: Febrile seizures (FS) are among the most common neurological emergencies duringchildhood and clinically classified into two types, being simple febrile seizures (SFS) andcomplicated febrile seizures (CFS). The differentiation between FS types is important, in thatthey are associated with different morbidity and mortality risks and it is based on the clinicalcharacteristics of each seizure, however there is currently no laboratory test that can guide thisdifferentiation. In this study, the relationship between FS types and hemogram parameters wasevaluated and potential use of these parameters in differential diagnosis was investigated.Material and Methods: This retrospective study included a total of 133 patients whose firstFS met the criteria of an FS, and whose hemogram results were available. The AmericanAcademy of Pediatrics criteria were used to confirm the diagnosis. The patients were dividedinto two groups as SFS and CFS.Results: Hemoglobin (Hb), hematocrit (HCT), mean platelet volume (MPV), neutrophillymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) differed significantly betweentwo groups (p<0.001, p=0.002, p=0.033, p<0.001, p<0.001, respectively), while no significantdifference was identified in total blood count parameters. Moreover, MPV was significantlyhigher in CFS group than in SFS group.Conclusion: This is one of the few studies investigating the potential relationship betweenhemogram parameters and FS types in children. We believe that, although they do not ensurea clear differentiation, Hb, MPV, NLR and PLR may be useful to clinicians in differentiatingbetween FS types, particularly in patients with an unclear seizure history