Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx

<p>Abstract</p> <p>Background</p> <p>The aim of this study was to assess the relationship between expression of vascular endothelial growth factor (VEGF) and phosphatase and tensin homolog deleted in chromosome ten (PTEN), angiogenesis and clinicopathological parameters of squamous cell carcinoma of the larynx.</p> <p>Methods</p> <p>We examined immunohistochemical expression of VEGF and PTEN and CD34 for microvessel density (MVD) in sections of formalin-fixed, paraffin embedded tissue blocks of 140 patients with squamous cell carcinoma of the larynx. The intensity of VEGF and PTEN staining and the proportion of cells staining were scored.</p> <p>Results</p> <p>The tumor grade was not significantly related to PTEN expression, but it was to VEGF expression (p = 0.400; p = 0.015, respectively). While there was no significant relationship between PTEN expression and tumor size and cartilage invasion (p = 0.311, p = 0.128), there was a significant relationship between the severity of VEGF expression and tumor size (p = 0.006) and lymph node metastasis (p = 0.048) but not cartilage invasion (p = 0.129). MVD was significantly higher in high-grade tumors (p = 0.003) but had no significant relationship between MVD, lymph node metastasis, and cartilage invasion (p = 0.815, p = 0.204). There was also no significant relationship between PTEN and VEGF expression (p = 0.161) and between PTEN and VEGF expression and the MVD (p = 0.120 and p = 0.175, respectively).</p> <p>Conclusions</p> <p>Increased VEGF expression may play an important role in the outcome of squamous cell carcinoma of the larynx. PTEN expression was not related to VEGF expression and clinicopathological features of squamous cell carcinoma of the larynx.</p

Pigmented Villonodular Synovitis in a Patient who Underwent Hip Arthroplasty

Pigmented villonodular synovitis (PVNS) is a rare, benign, but a locally aggressive tumor. It is characterized by the proliferation of synovial membrane, but it can also be seen in tendon sheaths and bursae. Clinical presentation of solitary lesions include compression and locking of the joint suggesting loose bodies in the joint and a subsequent findings of an effusion, whereas diffuse lesions manifest with pain and chronic swelling. In this article, we presented a curious case of PVNS in a female patient who have been followed up due to an acetabular cystic lesion. She underwent total hip arthroplasty for severe osteoarthritis of the hip joint and associated pain. The diagnosis of PVNS was established intraoperatively. (The Me­di­cal Bul­le­tin of Ha­se­ki 2014; 52: 235-7

Pilomatrixoma localized in the arm and forearm

Pilomatrixoma is a rare benign skin tumor arising from hair follicle stem cells which is also known as calcifying epithelioma of Malharbe. It occurs with a rate of 0.1% among skin tumors. The definite diagnosis is made histopathologically. In treatment, it is recommended that the lesion be excised surgically. In this study, we wished to present two patients who presented with swelling and underwent excisional biopsy as a result of magnetic resonance imaging and whose pathological result was reported to be pilomatrixoma in accompaniment with the literature

Akciğer kanserinin histopatolojik tipi zamanla değişiyor mu?

Akciğer kanseri, tüm dünyada kansere bağlı ölümlerde ilk sırayı almaktadır. Akciğer kanserinin histopatolojik tip dağılımda, geçen yıllar boyunca değişiklik olduğu bilinmektedir. Bu çalışma Ocak 1998 ile Aralık 2007 tarihleri arasında akciğer kanseri almış 1195 hastanın (%94 erkek, %6 kadın) epidemiyolojik özellikleri ile birlikte, hücre tipi dağılımındaki değişiklikleri retrospektif olarak incelemeyi amaçladık. Akciğer kanseri tanısı konulan hastaların yaş, cinsiyet, sigara içme durumları ve akciğer kanseri hücre tipleri değerlendirildi. Hastalar Ocak 1998 ile Aralık 2002 tarihleri arasında 1. Grup ve Ocak 2003 ile Aralık 2007 tarihleri arasında 2. Grup olarak iki gruba ayrıldı. En sık histopatolojik tip skuamoz hücreli kanser (% 59.1) idi, küçük hücreli akciğer kanseri ikinci en sık (%21.2) ve adenokarsinom (%13.6) idi. ‹ki grub incelendiğinde yıllar içinde skuamoz hücreli kanserde %60.1’den % 57.8’e azaldığı (% değişim % –4, p> 0.05) , küçük hücreli akciğer kanserinde %22.3’den %19.8’e azalma olduğu (% değişim % –11, p 0.05), that of small cell carcinoma decreased from 22.3% to 19.8% (a change of –11%, p< 0.05), and the incidence of adenocarcinoma increased from 11.8% to 15.9% (a change of +30%, p< 0.05). Although squamous cell carcinoma is still the most common type of lung cancer, there has been a significant increase in adenocarcinoma over time that would seem to be due to changes in the characteristics of cigarettes

Effects of intraperitoneal nitroglycerin on the strength and healing attitude of anastomosis of rat intestines with ischemia-reperfusion injury

Background: Ischemic conditions in the intestine result in deterioration of anastomosis healing process. In this study, our aim was to evaluate the possible effects of intraperitoneal nitroglycerin on the intestinal anastomosis healing and anastomosis burst pressures in rats with ischemia and reperfusion injury (I/R). Materials and Methods: Fifty four Wistar albino rats were divided into six groups. In the first two groups, the rats underwent I/R. In the Group 1, the rats had normal saline (S) and in Group 2, the rats had nitroglycerin (N) injection. In the 3 rd and 4 th groups, an intestinal anastomosis was made at the 10 cm proximally to the ileocecal valve. In Group 3, S and in Group 4, N were injected. In Group 5, the rats received I/R, intestinal anastomosis and intraperitoneal S injection. I/R, intestinal anastomosis and intraperitoneal N injection were made in Group 6 rats. All nitroglycerin (50 ΅g/kg) injections were made at postoperative days of 0, 1, 2, 3, 4, 5 consecutively. On the sixth day, all rats were killed. In all rats with anastomosis, anastomotic burst pressure (ABP) was measured. Histopathological specimens were collected from all rats and evaluated under light microscopy. Results: Serious tissue damage was only detected in the Group 1 histopathologically (8 rats had grade 4 damage). In Group 2, there was a decrease in tissue damage according to histopathologic examination (5 rats had grade 1 damage). The effect onto the healing was similar in S and N groups. Nitroglycerin was noted to have a positive effect on collagen production. Nitroglycerin increased the ABP levels in rats both with and without I/R (the means are 17.93, 21.10, 14.67, and 17.63 in Groups 3, 4, 5, and 6, respectively). Conclusion: I/R may weaken the strength of intestinal anastomosis. Intraperitoneal application of nitroglycerin may prevent the histopathologic changes within a limited degree. Intraperitoneal nitroglycerin has also positive effects on the healing of intestinal anastomosis of rats with and without I/R. It may increase the fibroblast proliferation and the strength of the anastomosis

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A 58-year-old male patient with a mass in the left side of the neck for 3 months was admitted to hospital. Physical examination revealed two masses; a mobile, painless, left jugular mass (lymphadenopathy?) and a parapharyngeal mass behind the left tonsilla palatina. Computed tomography examination of the cervical region and pharynx demonstrated two soft tissue masses. Th e fi rst mass was in the left parapharyngeal region and about 3.5x3x3 cm in dimensions. Th is mass was well-circumscribed and showed heterogeneous contrast uptake. Th e second one was 4.5x2.5x2 cm, sharply delineated and homogeneous. It was partly embedded in the caudal region of the left parotid gland. Th e initial clinical diagnosis was a probable metastatic malignant tumor. Fine needle aspiration was done for th