9 research outputs found
Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles
- Author
- A Pagano
- AL Rodriguez
- AL Rodriguez
- AM Loening
- Andrew S Felts
- AS Dore
- AS Felts
- Carrie K Jones
- Colleen M Niswender
- Craig W Lindsley
- D Berg
- DF Wong
- DJ Rubins
- H Wu
- HU Shetty
- I Kola
- J Logan
- J Logan
- J Scott Daniels
- JD Andersson
- Jerri M Rook
- JJ Anderson
- JM Rook
- JQ Wang
- KA Emmitte
- KJ Gregory
- KJ Gregory
- KJ Gregory
- Kyle A Emmitte
- L Mu
- M Bergstrom
- M Facklam
- MJ Noetzel
- Mohammad S Ansari
- Mohammed N Tantawy
- ND Cosford
- ND Cosford
- P Jeffrey Conn
- PJ Conn
- PJ Conn
- R Williams
- Robert M Kessler
- S A Castner
- S Jacquemont
- S Patel
- Shaun R Stauffer
- SM Ametamey
- TG Hamill
- VJ Majo
- Y Chen
- Y Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textStrategies to select the best pharmacophore model: a case study in pyrazoloquinazoline class of PLK-1 inhibitors
- Author
- AJ Joshi
- Akshada J. Joshi
- CG Wermuth
- DM Glover
- EA Nigg
- EJ Hanan
- G Wolf
- G Wolf
- Heena R. Bhojwani
- HS Lee
- HY Wang
- I Beria
- I Beria
- I Beria
- J Kirchmair
- K Dietzmann
- KA Emmitte
- KY Cheng
- L He
- M Caruso
- M Cheung
- M Kothe
- MN Drwal
- MO Duffey
- MPA Sanders
- N Takai
- O Dror
- PJ Gray
- R Hamanaka
- R Knecht
- RC Braga
- RV Fucini
- S Chen
- SL Dixon
- Urmila J. Joshi
- W Weichert
- Y Sato
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textStructure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni
- Author
- A Domling
- A Guidi
- A Moody-Davis
- AA Sabah
- AD Aragon
- AG Gilmartin
- AN Kuntz
- B Ramirez
- BE Swierczewski
- BJ Neves
- Brian M. Suzuki
- BT Gjertsen
- C Dissous
- C Doerig
- Chakrapani Kalyanaraman
- CL Valentim
- Colette Dissous
- Conor R. Caffrey
- CR Caffrey
- CR Caffrey
- CR Caffrey
- CR Chong
- D Asarnow
- D Asarnow
- D Cioli
- D Olmos
- D Rudolph
- D Rudolph
- David H. Drewry
- DC Swinney
- DG Colley
- FA Barr
- G de Carcer
- G Patel
- H Lee
- J Dvorak
- J Eder
- J Glaser
- J Yuan
- JA Lee
- James H. McKerrow
- JM Elkins
- K Ingram-Sieber
- K Strebhardt
- K Strebhardt
- KA Emmitte
- KA Emmitte
- KJ Livak
- KU Buhring
- L Cheng
- L Garuti
- L Rojo-Arreola
- LF Andrade
- M Janning
- M Kaiser
- M Morel
- M Steegmaier
- Matthew P. Jacobson
- MH Abdulla
- MH Abdulla
- MJ Doenhoff
- N Takai
- NC Fonseca
- P Andrews
- P Lenart
- P Olliaro
- P Ross-Macdonald
- PF Basch
- R Jain
- R. Jeffrey Neitz
- RA Abdul-Ghani
- RA Paveley
- Rachel Beasley
- Rahul Singh
- RH Duvall
- S Beckmann
- S Beckmann
- S Stefanic
- S Zitouni
- SA Thetiot-Laurent
- SH Xiao
- SN Craig
- T Long
- T Long
- T Meyer
- TG Geary
- Thavy Long
- Timothy G. Geary
- TJ Lansing
- TR Rheault
- U Saha
- V Archambault
- V Archambault
- V Archambault
- W Reindl
- W Reindl
- W Wang
- William J. Zuercher
- Y Degenhardt
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
No full textDissecting the phenotypes of Plk1 inhibition in cancer cells using novel kinase inhibitory chemical CBB2001
- Author
- A Seki
- C Baumann
- CL Morton
- EF Johnson
- F Eckerdt
- F Lu
- F Toyoshima-Morimoto
- FA Barr
- Fei Lu
- Feng Yin
- Guimiao Lin
- H Nakajima
- Hanbing Zhong
- Hui Zhang
- J Pouwels
- Jianxian Gong
- Jing Wang
- JR Bischoff
- Jun Xu
- K Strebhardt
- KA Emmitte
- L Macurek
- LA Higa
- LA Higa
- LA Higa
- M Kothe
- N Keen
- N Oshimori
- O Trott
- P Lenart
- P Meraldi
- P Schoffski
- Q Chen
- R Guan
- RM Golsteyn
- Rongfeng Lan
- S Cooper
- S Kanaji
- S Taylor
- SM Yun
- T Bashir
- T Takahashi
- W Wei
- X Liu
- X Liu
- Xiaoming Zhang
- Y Kurasawa
- Y Moshe
- Y Yamamoto
- Yanchao Wang
- Yuan-Hua Ding
- Zhen Yang
- ZQ Wu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textPartial mGlu5 Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects
- Author
- A Christopoulos
- A Gravius
- A Gravius
- A Pisani
- AJ McGeehan
- AL Rodriguez
- AL Rodriguez
- Alice L Rodriguez
- Analisa D Thompson
- Andrew S Felts
- AS Felts
- B Lee
- C Goudet
- Carrie K Jones
- CK Jones
- CM Niswender
- Colleen M Niswender
- Craig W Lindsley
- CS Busse
- CTH Friedmann
- D Berg
- D Shorter
- EL van der Kam
- F Borsini
- F Gasparini
- F Vorspan
- Frank W Byers
- G Mannaioni
- GG Kinney
- H Homayoun
- HC Yan
- HH Nickols
- Hilary H Nickols
- JC Pecknold
- Jerri M Rook
- JJ Anderson
- JJ Crowley
- JM Rook
- Johannes P Yuh
- John S Daniels
- JR Roppe
- JT Coyle
- K Golembiowska
- K Rutten
- KA Emmitte
- KT Brady
- Kyle A Emmitte
- L Lindemann
- M Bubser
- M Pietraszek
- M Thomsen
- Max E Joffe
- MD Swedberg
- Michael Bubser
- Michael T Nedelcovych
- MJ Marino
- MJ Noetzel
- MK Bird
- ND Cosford
- ND Volkow
- NE Byun
- NE Paterson
- OV Gurkovskaya
- P Backstrom
- P Jeffrey Conn
- PJ Conn
- PJ Kenny
- R Young
- RH Porter
- RJ Amato
- RM Brown
- Robert W Gould
- Russell J Amato
- Ryan D Morrison
- S Fujii
- S Jacquemont
- S Terbeck
- SA Henry
- T Hiranita
- T Kishi
- TJ Moore
- TM Ballard
- TM Keck
- TM Keck
- TM Keck
- V Herzig
- V Kumaresan
- Xiaoyan Zhan
- ZA Hughes
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textPolo-Like Kinases in Colorectal Cancer: Potential for Targeted Therapy
- Author
- A Ahr
- A Jimeno
- A Jimeno
- A Krause
- AD Judge
- AH Sillars-Hardebol
- AJ Holland
- AJ Holland
- B Li
- B Song
- B Spankuch
- B Spankuch-Schmitt
- B Spankuch-Schmitt
- B Valsasina
- BT Gjertsen
- C Fode
- Carol J. Swallow
- CH Park
- CO Rosario
- CW Conn
- D Kong
- D Olmos
- D Rudolph
- D Rudolph
- D Xu
- David Berger-Richardson
- DL Myer
- DL Simmons
- DW Bowles
- E Hatzimichael
- E Villegas
- E Viron de
- EF Johnson
- F Eckerdt
- F Rodel
- F Toyoshima-Morimoto
- F Valenti
- Francis S. W. Zih
- G Carcer de
- G Wolf
- G Wolf
- GV Glinsky
- H Dohner
- H Tanaka
- HA Lane
- HJ Nam
- I Beria
- I Steinhauser
- I Sumara
- IM Steinhauser
- J Chang
- J Kleylein-Sohn
- J Li
- J Wang
- J Yuan
- JC Macmillan
- JE Sillibourne
- Jennifer Macmillan
- JM Mason
- JM Vose
- JP Cogswell
- JW Hudson
- K Ando
- K Dietzmann
- K Gumireddy
- K Mito
- K Mross
- K Mross
- K Strebhardt
- KA Emmitte
- KA Emmitte
- Karina Pacholczyk
- Karineh Kazazian
- L Benetatos
- L Kneisel
- L Liu
- LB Tan
- LJ Ahonen
- LL Garland
- LS Schwartzberg
- LY Lu
- M Bahassi el
- M Bettencourt-Dias
- M Casenghi
- M Janning
- M Nishino
- M Raab
- M Sebastian
- M Steegmaier
- M Takagi
- MA Ko
- ME Burkard
- MR Smith
- N Jiang
- N Syed
- N Syed
- N Takai
- N Takai
- N Takai
- O Cizmecioglu
- Olga Brashavitskaya
- P Finetti
- P Schoffski
- P Schoffski
- P Smith
- PA Coelho
- PJ Donohue
- PJ Gray Jr
- PM Ellis
- Q Wang
- R Agarwal
- R Basto
- R Guan
- R Habedanck
- R Hiremath
- R Knecht
- R Knecht
- R Pellegrino
- RD Hofheinz
- RM Golsteyn
- RM Harris
- Roland S. Z. Xu
- RS Komrokji
- S Ma
- S Reagan-Shaw
- S Warnke
- S Xie
- S Xie
- S Yamada
- S Zitouni
- T Fujiwara
- T Ohnuma
- T Takahashi
- TF Burns
- V Baran
- V Heinemann
- V Joukov
- V Marthiens
- W Dai
- W Ju
- W Reindl
- W Weichert
- W Weichert
- W Weichert
- W Weichert
- W Weichert
- WC Zimmerman
- WL Lingle
- WM Stadler
- WW Ma
- X Liu
- X Liu
- X Liu
- Y Feng
- Y Tokumitsu
- Y Yang
- YH Kang
- YW Qian
- Z Andrysik
- Z Li
- ZQ Wu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textModulating Polo-Like Kinase 1 as a Means for Cancer Chemoprevention
- Author
- A Santamaria
- A Seki
- AE Elia
- AG Gilmartin
- AK Roshak
- C Agarwal
- C McInnes
- CD Mann
- CE Sunkel
- CH Cheung
- CK Taylor
- CL Randall
- CM Sorrels
- CS Stevenson
- D Rudolph
- DV Hansen
- EH Chan
- EH Walker
- EJ Noh
- F Eckerdt
- F Garcia-Pichel
- F Toyoshima-Morimoto
- G Eisenbrand
- GJ Brunn
- GJ Kops
- GY Kang
- H Gali-Muhtasib
- IA Ismail
- JD Reimann
- JM Peters
- JS Lee
- K Ho
- K Mross
- K Ramasamy
- K Strebhardt
- K Strebhardt
- KA Emmitte
- KS Lee
- L Kneisel
- L Macurek
- LL Parker
- LM De
- M Johansson
- M Kaur
- M Nogawa
- M Steegmaier
- M Yoshida
- Mark C. Ledesma
- ME Burkard
- ME Burkard
- MP Wymann
- MR Smith
- MS Coumar
- N Takai
- N Tsuji
- N Watanabe
- Nihal Ahmad
- P Schoffski
- P Vuorelaa
- PR Mueller
- R Hoessel
- R Leuken van
- S Lapenna
- S Leclerc
- S Llamazares
- S Nam
- S Simizu
- S Yamada
- SA Kim
- SA Kim
- SE Kulling
- SH Kim
- T Berg
- T Ikezoe
- TL Schmit
- TL Schmit
- TL Schmit
- Travis L. Schmit
- V Archambault
- W Cui
- W Reindl
- W Weichert
- W Weichert
- W Weichert
- W Weichert
- W Weichert
- W Weichert
- WY Cheng
- Y Liu
- Y Liu
- Y Moshe
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textOpportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders
- Author
- A Christopoulos
- A Goshal
- A Levoye
- A Satoh
- AC Kruse
- AE Brady
- AE Davey
- AL Rodriguez
- AL Rodriguez
- AS Doré
- BJ Melancon
- BJ Melancon
- C Romano
- C Sur
- C Valant
- C Valant
- CI Wang
- CJ Langmead
- CJ Wenthur
- CJ Wenthur
- CK Jones
- CK Jones
- CM Niswender
- CM Niswender
- CM Niswender
- CM Reichel
- Colleen M. Niswender
- CR Hopkins
- Craig W. Lindsley
- CW Lindsley
- D Balschun
- D Ortuno
- D Wootten
- DJ Foster
- DJ Sheffler
- DJ Sheffler
- DT Chalmers
- E Doumazane
- E Kostenis
- E Le Poul
- ED Nguyen
- EL Maillet
- EP Lebois
- F Gasparini
- F Gastambide
- F Gastambide
- F Liu
- FS Menniti
- FV Yang
- G Lebon
- G Milligan
- G Milligan
- GJ Digby
- GJ Digby
- GJ Digby
- GJ Macdonald
- H Annoura
- H Brauner-Osborne
- H Lavreysen
- H Möhler
- H Sanger
- H Wu
- HH Nickols
- I Kola
- J Kniazeff
- J Shirey
- J Xu
- JA O'Brien
- JE Ayala
- JE Marlo
- Jens Meiler
- JK Archbold
- JK Shirey
- JK Shirey
- JM Darrah
- JM Mathiesen
- JM Rook
- JP Changeux
- JP Overington
- JP Pin
- JP Rocher
- JS Lindberg
- K Hemstapat
- K Hollenstein
- K Leach
- K Leach
- K Leach
- KA Emmitte
- KE Bennouar
- KH Ahn
- KJ Gregory
- KJ Gregory
- KJ Gregory
- KJ Gregory
- KM Huber
- L Lecourtier
- L Lundstrom
- L Ma
- LB Knudsen
- LT May
- M Canals
- M Kalinichev
- M López De Jesús
- MA Ayoub
- MA Ayoub
- MA Varney
- MC Lagerström
- MF Bear
- MJ Marino
- MJ Noetzel
- MJ Noetzel
- MP Bokoch
- MR Price
- MR Wood
- NE Byun
- O Valenti
- P Dorr
- P Malherbe
- P. Jeffrey Conn
- PE Harrington
- PJ Conn
- PJ Jones
- PJ Kammermeier
- R Rozenfeld
- RK Wong
- RO Dror
- S AbdAlla
- S Ferre
- S Ferre
- S Litschig
- S Mukherjee
- S Parmentier-Batteur
- S Parmentier-Batteur
- S Schann
- S Sharma
- S Sharma
- S Suratman
- S Urwyler
- S Yin
- SN Mistry
- SR Hoare
- T Gjoni
- T Kenakin
- T Kenakin
- TA Spalding
- TM Bridges
- V Hlavackova
- V Katritch
- VA Avlani
- WY Chan
- X Li
- X Wang
- Y Chen
- Y Zhang
- Z Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full text
