90 research outputs found
Plasticity performance of Al0.5CoCrCuFeNi high-entropy alloys under nanoindentation
The statistical and dynamic behaviors of the displacement-load curves of a high-entropy alloy Al0.3CoCrCuFeNi were analyzed for the nanoindentation performed at two temperatures. Critical behavior of serrations at room temperature and chaotic flows at 200 degrees C were detected. These results are attributed to the interaction among a large number of slip hands. For the nanoindentation at room temperature recurrent partial events between slip hands introduce a hierarchy of length scales leading to a critical state. For the nanoindentation at 200 degrees C there is no spatial interference between two slip hands which is corresponding to the evolution of separated trajectory of chaotic behavior
Crackling Noise
Crackling noise arises when a system responds to changing external conditions
through discrete, impulsive events spanning a broad range of sizes. A wide
variety of physical systems exhibiting crackling noise have been studied, from
earthquakes on faults to paper crumpling. Because these systems exhibit regular
behavior over many decades of sizes, their behavior is likely independent of
microscopic and macroscopic details, and progress can be made by the use of
very simple models. The fact that simple models and real systems can share the
same behavior on a wide range of scales is called universality. We illustrate
these ideas using results for our model of crackling noise in magnets,
explaining the use of the renormalization group and scaling collapses. This
field is still developing: we describe a number of continuing challenges
A Ligand Peptide Motif Selected from a Cancer Patient Is a Receptor-Interacting Site within Human Interleukin-11
Interleukin-11 (IL-11) is a pleiotropic cytokine approved by the FDA against chemotherapy-induced thrombocytopenia. From a combinatorial selection in a cancer patient, we isolated an IL-11-like peptide mapping to domain I of the IL-11 (sequence CGRRAGGSC). Although this motif has ligand attributes, it is not within the previously characterized interacting sites. Here we design and validate in-tandem binding assays, site-directed mutagenesis and NMR spectroscopy to show (i) the peptide mimics a receptor-binding site within IL-11, (ii) the binding of CGRRAGGSC to the IL-11Rα is functionally relevant, (iii) Arg4 and Ser8 are the key residues mediating the interaction, and (iv) the IL-11-like motif induces cell proliferation through STAT3 activation. These structural and functional results uncover an as yet unrecognized receptor-binding site in human IL-11. Given that IL-11Rα has been proposed as a target in human cancer, our results provide clues for the rational design of targeted drugs
Deformation behavior of bulk metallic glasses under a mixed-mode (I/II) loading condition
202402 bcchAccepted ManuscriptRGCOthersDepartment of Energy (DOE), Office of Fossil Energy, National Energy Technology Laboratory; U.S. Army Research Office project; National Science FoundationPublishedGreen (AAM
Loading-rate-independent delay of catastrophic avalanches in a bulk metallic glass
2015-2016 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
- …