Formulation and evaluation of pulsatile drug delivery system for chronobiological disorder: Asthma

The objective of the present study was to develop and evaluate an oral pulsatile drug delivery system to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 6 h (± 0.25 h). The basic design of the system consisted of a rapid release tableted core and a controlled release tableted coat. A combination of Isopropyl Alcohol (70%) and Acetone (30%) was used as solvent for Eudragit S100 coating. An in vitro dissolution study of the prepared tablet was conducted initially for 2 h in simulated gastric fluid and after that medium was changed to intestinal fluid pH 7.4.Keywords: Pulsatile drug delivery system, Lag time, Circadian rhythm, Eudragit S100