127 research outputs found
Intraluminal Hexadecane Enhances Large Intestinal Excretion of Tissue Hexachlorobenzene in Rats (Liquid paraffins; halogenated hydrocarbons; non-biliary, intestinal excretion).
Intraluminal hexadecane enhances large intestinal excretion of tissue hexachlorobenzene in rats.
In young adult female rats with a cecal stoma, administration of hexadecane into the stomach (750 or 500 mg) and into the ligated colon (250 mg) enhanced 2- to 3-fold the intestinal excretion of [14C]hexachlorobenzene. Apparent sites of increased transferral from the blood into luminal contents were (caudal) ileum, cecum and colon. Presence of nonabsorbed hexadecane in luminal contents seems to be a prerequisite for the effects. Results support previous reports that enhancement of intestinal excretion of lipophilic chemicals by liquid paraffins takes place in the large intestine
Approaches for Using Toxicokinetic Information in Assessing Risk to Deployed U.S. Forces.
Letters to the Editor: This letter concerns the article by Howie et al. in Toxicol.Appl.Pharmacol. 105, 254-263 (1990).
Phase II Enzyme Induction Reduces Body Burden of Heptachlor in Rats (Pesticide; Decontamination; Kinetics; Trans-stilbene Oxide).
Use of Acute Toxicity Data in the Design and Interpretation of Subchronic and Chronic Toxicity Studies.
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