Quark energy loss and shadowing in nuclear Drell-Yan process

The energy loss effect in nuclear matter is another nuclear effect apart from the nuclear effects on the parton distribution as in deep inelastic scattering process. The quark energy loss can be measured best by the nuclear dependence of the high energy nuclear Drell-Yan process. By means of three kinds of quark energy loss parameterizations given in literature and the nuclear parton distribution extracted only with lepton-nucleus deep inelastic scattering experimental data, measured Drell-Yan production cross sections are analyzed for 800GeV proton incident on a variety of nuclear targets from FNAL E866. It is shown that our results with considering the energy loss effect are much different from these of the FNAL E866 who analysis the experimental data with the nuclear parton distribution functions obtained by using the deep inelastic lA collisions and pA nuclear Drell-Yan data . Considering the existence of energy loss effect in Drell-Yan lepton pairs production,we suggest that the extraction of nuclear parton distribution functions should not include Drell-Yan experimental data.Comment: 12 page

Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time

10.2147/CIA.S32513Clinical Interventions in Aging7303-31

Changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time

10.2147/CIA.S35202Clinical Interventions in Aging7373-38

Shifting a Quantum Wire through a Disordered Crystal: Observation of Conductance Fluctuations in Real Space

A quantum wire is spatially displaced by suitable electric fields with respect to the scatterers inside a semiconductor crystal. As a function of the wire position, the low-temperature resistance shows reproducible fluctuations. Their characteristic temperature scale is a few hundred millikelvin, indicating a phase-coherent effect. Each fluctuation corresponds to a single scatterer entering or leaving the wire. This way, scattering centers can be counted one by one.Comment: 4 pages, 3 figure

The Leptonic Higgs as a Messenger of Dark Matter

We propose that the leptonic cosmic ray signals seen by PAMELA and ATIC result from the annihilation or decay of dark matter particles via states of a leptonic Higgs doublet to $\tau$ leptons, linking cosmic ray signals of dark matter to LHC signals of the Higgs sector. The states of the leptonic Higgs doublet are lighter than about 200 GeV, yielding large $\bar{\tau} \tau$ and $\bar{\tau} \tau \bar{\tau} \tau$ event rates at the LHC. Simple models are given for the dark matter particle and its interactions with the leptonic Higgs, for cosmic ray signals arising from both annihilations and decays in the galactic halo. For the case of annihilations, cosmic photon and neutrino signals are on the verge of discovery.Comment: 34 pages, 9 figures, minor typos corrected, references adde

Nuclear effects on J/{\psi} production in proton-nucleus collisions

The study of nuclear effects for J/{\psi} production in proton-nucleus collisions is crucial for a correct interpretation of the J/{\psi} suppression patterns experimentally observed in heavy-ion collisions. By means of three representative sets of nuclear parton distribution, the energy loss effect in the initial state and the nuclear absorption effect in the final state are taken into account in the uniform framework of the Glauber model. A leading order phenomenological analysis is performed on J/{\psi} production cross-section ratios RW/Be(xF) for the E866 experimental data. The J/{\psi} suppression is investigated quantitatively due to the different nuclear effects. It is shown that the energy loss effect with resulting in the suppression on RW/Be(xF) is more important than the nuclear effects on parton distributions in high xF region. The E866 data in the small xF keep out the nuclear gluon distribution with a large anti-shadowing effect. However, the new HERA-B measurement is not in support of the anti-shadowing effect in the nuclear gluon distribution. It is found that the J/{\psi}-nucleon inelastic cross section {\sigma} J/{\psi} abs depends on the kinematical variable xF, and increases as xF in the region xF > 0.2. 1 Introductio

Structure-activity investigation of a G protein-biased agonist reveals molecular determinants for biased signaling of the D2 dopamine receptor

The dopamine D2 receptor (D2R) is known to elicit effects through activating two major signaling pathways mediated by either G proteins (Gi/o) or β-arrestins. However, the specific role of each pathway in physiological or therapeutic activities is not known with certainty. One approach to the dissection of these pathways is through the use of drugs that can selectively modulate one pathway vs. the other through a mechanism known as functional selectivity or biased signaling. Our laboratory has previously described a G protein signaling-biased agonist, MLS1547, for the D2R using a variety of in vitro functional assays. To further evaluate the biased signaling activity of this compound, we investigated its ability to promote D2R internalization, a process known to be mediated by β-arrestin. Using multiple cellular systems and techniques, we found that MLS1547 promotes little D2R internalization, which is consistent with its inability to recruit β-arrestin. Importantly, we validated these results in primary striatal neurons where the D2R is most highly expressed suggesting that MLS1547 will exhibit biased signaling activity in vivo. In an effort to optimize and further explore structure-activity relationships (SAR) for this scaffold, we conducted an iterative chemistry campaign to synthesize and characterize novel analogs of MLS1547. The resulting analysis confirmed previously described SAR requirements for G protein-biased agonist activity and, importantly, elucidated new structural features that are critical for agonist efficacy and signaling bias of the MLS1547 scaffold. One of the most important determinants for G protein-biased signaling is the interaction of a hydrophobic moiety of the compound with a defined pocket formed by residues within transmembrane five and extracellular loop two of the D2R. These results shed new light on the mechanism of biased signaling of the D2R and may lead to improved functionally-selective molecules

PAMELA/ATIC anomaly from the meta-stable extra dark matter component and the leptophilic Yukawa interaction

We present a supersymmetric model with two dark matter (DM) components explaining the galactic positron excess observed by PAMELA/HEAT and ATIC/PPB-BETS: One is the conventional (bino-like) lightest supersymmetric particle (LSP) \chi, and the other is a TeV scale meta-stable neutral singlet N_D, which is a Dirac fermion (N,N^c). In this model, N_D decays dominantly into \chi e^+e^- through an R parity preserving dimension 6 operator with the life time \tau_N\sim 10^{26} sec. We introduce a pair of vector-like superheavy SU(2) lepton doublets (L,L^c) and lepton singlets (E,E^c). The dimension 6 operator leading to the N_D decay is generated from the leptophilic Yukawa interactions by W\supset Ne^cE+Lh_dE^c+m_{3/2}l_1L^c with the dimensionless couplings of order unity, and the gauge interaction by {\cal L}\supset \sqrt{2} g'\tilde{e}^{c*}e^c\chi + h.c. The superheavy masses of the vector-like leptons (M_L, M_E\sim 10^{16} GeV) are responsible for the longevity of N_D. The low energy field spectrum in this model is just the MSSM fields and N_D. Even for the case that the portion of N_D is much smaller than that of \chi in the total DM density [{\cal O}(10^{-10}) \lesssim n_{N_D}/n_\chi], the observed positron excess can be explained by adopting relatively lighter masses of the vector-like leptons (10^{13} GeV \lesssim M_{L,E} \lesssim 10^{16} GeV). The smallness of the electron mass is also explained. This model is easily embedded in the flipped SU(5) grand unification, which is a leptophilic unified theory.Comment: 12 pages, published versio

Dark matter and collider phenomenology of split-UED

We explicitly show that split-universal extra dimension (split-UED), a recently suggested extension of universal extra dimension (UED) model, can nicely explain recent anomalies in cosmic-ray positrons and electrons observed by PAMELA and ATIC/PPB-BETS. Kaluza-Klein (KK) dark matters mainly annihilate into leptons because the hadronic branching fraction is highly suppressed by large KK quark masses and the antiproton flux agrees very well with the observation where no excess is found . The flux of cosmic gamma-rays from pion decay is also highly suppressed and hardly detected in low energy region (E<20 GeV). Collider signatures of colored KK particles at the LHC, especially q_1 q_1 production, are studied in detail. Due to the large split in masses of KK quarks and other particles, hard p_T jets and missing E_T are generated, which make it possible to suppress the standard model background and discover the signals.Comment: 32 pages, 15 figure

Impact of chronic obstructive pulmonary disease and dyspnoea on clinical outcomes in ticagrelor treated patients undergoing percutaneous coronary intervention in the randomized GLOBAL LEADERS trial

AIMS: To evaluate long-term safety and efficacy of ticagrelor monotherapy in patients undergoing percutaneous coronary interventions (PCIs) in relation to chronic obstructive pulmonary disease (COPD) at baseline and the occurrence of dyspnoea reported as adverse event (AE) that may lead to treatment non-adherence. METHODS AND RESULTS: This is a non-prespecified, post hoc analysis of the randomized GLOBAL LEADERS trial (n = 15 991), comparing the experimental strategy of 23-month ticagrelor monotherapy following 1-mo