Bite the apple, get driven out of the garden: A risky story telling at the ASME town meeting

Risk, the all-encompassing four-letter word became a widely used household cliche and an institutional mantra in the nineties. Risk analysis models from the Garden of Eden to the Capitol Hill lawn have made a number of sharp paradigm shifts to evolve itself as a decision-making tool from individual risk perception to societal risk-based regulatory media. Risk always coexists with benefit and is arbitrated by costs. Risk-benefit analysis has been in use in business and industry in economic ventures for a long time. Only recently risk management in its current state of development, evolved as a regulatory tool for controlling large technological systems that have potential impacts on the health and safety of the public and on the sustainability of the ecology and the environment. This paper summarizes the evolution of the risk management concepts and models in industry and the regulatory agencies in the US over the last three decades. It also discusses the benefits and limitations of this evolving discipline as it is applied to high-risk technologies from the nuclear power plant and petrochemical industry, etc. to nuclear weapons technology

Development of a guidance document for lightning protection of DOE facilities

The purpose of this guidance document is to introduce Lighting Hazard Management, a unified approach that combines hazard identification and facility categorization (not discussed in this paper) with a new concept -- the Lighting Safety System. We do not intend to develop a brand new lightning code or standard, but rather reference other codes, standards and guides that we determine to be applicable. Using the graded approach to systematic risk management allows for in-depth protection and aids in ensuring personnel safety and optimizing resource protection

On reactor type comparisons for the next generation of reactors

In this paper, we present a broad comparison of studies for a selected set of parameters for different nuclear reactor types including the next generation. This serves as an overview of key parameters which provide a semi-quantitative decision basis for selecting nuclear strategies. Out of a number of advanced reactor designs of the LWR type, gas cooled type, and FBR type, currently on the drawing board, the Advanced Light Water Reactors (ALWR) seem to have some edge over other types of the next generation of reactors for the near-term application. This is based on a number of attributes related to the benefit of the vast operating experience with LWRs coupled with an estimated low risk profile, economics of scale, degree of utilization of passive systems, simplification in the plant design and layout, modular fabrication and manufacturing. 32 refs., 1 fig., 3 tabs

Systems reliability analysis for the national ignition facility

A Reliability, Availability and Maintainability (RAM) analysis was initiated for the National Ignition Facility (NIF). The NIF is an inertial confinement fusion research facility designed to achieve controlled thermonuclear reaction; the preferred site for the NIF is the Lawrence Livermore National Laboratory (LLNL). The NIF RAM analysis has three purposes: (1) to allocate top level reliability and availability goals for the systems, (2) to develop an operability model for optimum maintainability, and (3) to determine the achievability of the allocated goals of the RAM parameters for the NIF systems and the facility operation as a whole. An allocation model assigns the reliability and availability goals for front line and support systems by a top-down approach; reliability analysis uses a bottom-up approach to determine the system reliability and availability from component level to system level

Binding interaction of phosphorus heterocycles with bovine serum albumin: A biochemical study

Interaction between bovine serum albumin (BSA) and phosphorus heterocycles (PHs) was studied using multi-spectroscopic techniques. The results indicated the high binding affinity of PHs to BSA as it quenches the intrinsic fluorescence of BSA. The experimental data suggested the fluorescence quenching mechanism between PHs and BSA as a dynamic quenching. From the UV–vis studies, the apparent association constant (Kapp) was found to be 9.25×102, 1.27×104 and 9.01×102 L/mol for the interaction of BSA with PH-1, PH-2 and PH-3 respectively. According to the Förster's non-radiation energy transfer (FRET) theory, the binding distances between BSA and PHs were calculated. The binding distances (r) of PH-1, PH-2 and PH-3 were found to be 2.86, 3.03, and 5.12 nm, respectively, indicating energy transfer occurs between BSA and PHs. The binding constants of the PHs obtained from the fluorescence quenching data were found to be decreased with increase of temperature. The negative values of the thermodynamic parameters ΔH, ΔS and ΔG at different temperatures revealed that the binding process is spontaneous; hydrogen bonds and van der Waals interaction were the main force to stabilize the complex. The microenvironment of the protein-binding site was studied by synchronous fluorescence and circular dichroism (CD) techniques and data indicated that the conformation of BSA changed in the presence of PHs. Finally, we studied the BSA-PHs docking using Autodock and results suggest that PHs is located in the cleft between the domains of BSA