13 research outputs found
Antimatter from the cosmological baryogenesis and the anisotropies and polarization of the CMB radiation
We discuss the hypotheses that cosmological baryon asymmetry and entropy were
produced in the early Universe by phase transition of the scalar fields in the
framework of spontaneous baryogenesis scenario. We show that annihilation of
the matter-antimatter clouds during the cosmological hydrogen recombination
could distort of the CMB anisotropies and polarization by delay of the
recombination. After recombination the annihilation of the antibaryonic clouds
(ABC) and baryonic matter can produce peak-like reionization at the high
redshifts before formation of quasars and early galaxy formation. We discuss
the constraints on the parameters of spontaneous baryogenesis scenario by the
recent WMAP CMB anisotropy and polarization data and on possible manifestation
of the antimatter clouds in the upcoming PLANCK data.Comment: PRD in press with minor change
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria