GRBs Optical follow-up observation at Lulin observatory, Taiwan

The Lulin GRB program, using the Lulin One-meter Telescope (LOT) in Taiwan started in July 2003. Its scientific aims are to discover optical counterparts of XRFs and short and long GRBs, then to quickly observe them in multiple bands. Thirteen follow-up observations were provided by LOT between July 2003 and Feb. 2005. One host galaxy was found at GRB 031203. Two optical afterglows were detected for GRB 040924 and GRB 041006. In addition, the optical observations of GRB 031203 and a discussion of the non-detection of the optical afterglow of GRB 031203 are also reported in this article.Comment: 5 pages, 2 figure. Accepted for publication into "il nuovo cimento". Proceeding of the 4th Rome GRB conference, eds. L. Piro, L. Amati, S. Covino, B. Gendr

Particle acceleration and the origin of gamma-ray emission from Fermi Bubbles

Fermi LAT has discovered two extended gamma-ray bubbles above and below the galactic plane. We propose that their origin is due to the energy release in the Galactic center (GC) as a result of quasi-periodic star accretion onto the central black hole. Shocks generated by these processes propagate into the Galactic halo and accelerate particles there. We show that electrons accelerated up to ~10 TeV may be responsible for the observed gamma-ray emission of the bubbles as a result of inverse Compton (IC) scattering on the relic photons. We also suggest that the Bubble could generate the flux of CR protons at energies > 10^15 eV because the shocks in the Bubble have much larger length scales and longer lifetimes in comparison with those in SNRs. This may explain the the CR spectrum above the knee.Comment: 5 pages, 4 figures. Expanded version of the contribution to the 32nd ICRC, Beijing, #0589. To appear in the proceeding

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD. In AD, the accumulation of β-amyloid (Aβ) in the brain perturbs physiological functions of the brain, including synaptic and neuronal dysfunction, microglial activation, and neuronal loss. Serum levels of soluble ST2 (sST2), a decoy receptor for interleukin (IL)-33, increase in patients with mild cognitive impairment, suggesting that impaired IL-33/ST2 signaling may contribute to the pathogenesis of AD. Therefore, we investigated the potential therapeutic role of IL-33 in AD, using transgenic mouse models. Here we report that IL-33 administration reverses synaptic plasticity impairment and memory deficits in APP/PS1 mice. IL-33 administration reduces soluble Aβ levels and amyloid plaque deposition by promoting the recruitment and Aβ phagocytic activity of microglia; this is mediated by ST2/p38 signaling activation. Furthermore, IL-33 injection modulates the innate immune response by polarizing microglia/macrophages toward an antiinflammatory phenotype and reducing the expression of proinflammatory genes, including IL-1β, IL-6, and NLRP3, in the cortices of APP/PS1 mice. Collectively, our results demonstrate a potential therapeutic role for IL-33 in AD

Optical Afterglow Observations of the Unusual Short-Duration Gamma-Ray Burst 040924

The 1-m telescope at Lulin Observatory and the 0.76-m Katzman Automatic Imaging Telescope at Lick Observatory were used to observe the optical afterglow of the short-duration (1.2--1.5 s) gamma-ray burst (GRB) 040924. This object has a soft high-energy spectrum, thus making it an exceptional case, perhaps actually belonging to the short-duration tail of the long-duration GRBs. Our data, combined with other reported measurements, show that the early R-band light curve can be described by two power laws with index alpha = -0.7 (at t = 16-50 min) and alpha = -1.06 (at later times). The rather small difference in the spectral indices can be more easily explained by an afterglow model invoking a cooling break rather than a jet break.Comment: 13 pages, 3 figures, accepted for publication in ApJ

Systems-Level Comparison of Host-Responses Elicited by Avian H5N1 and Seasonal H1N1 Influenza Viruses in Primary Human Macrophages

Human disease caused by highly pathogenic avian influenza (HPAI) H5N1 can lead to a rapidly progressive viral pneumonia leading to acute respiratory distress syndrome. There is increasing evidence from clinical, animal models and in vitro data, which suggests a role for virus-induced cytokine dysregulation in contributing to the pathogenesis of human H5N1 disease. The key target cells for the virus in the lung are the alveolar epithelium and alveolar macrophages, and we have shown that, compared to seasonal human influenza viruses, equivalent infecting doses of H5N1 viruses markedly up-regulate pro-inflammatory cytokines in both primary cell types in vitro. Whether this H5N1-induced dysregulation of host responses is driven by qualitative (i.e activation of unique host pathways in response to H5N1) or quantitative differences between seasonal influenza viruses is unclear. Here we used microarrays to analyze and compare the gene expression profiles in primary human macrophages at 1, 3, and 6 h after infection with H5N1 virus or low-pathogenic seasonal influenza A (H1N1) virus. We found that host responses to both viruses are qualitatively similar with the activation of nearly identical biological processes and pathways. However, in comparison to seasonal H1N1 virus, H5N1 infection elicits a quantitatively stronger host inflammatory response including type I interferon (IFN) and tumor necrosis factor (TNF)-α genes. A network-based analysis suggests that the synergy between IFN-β and TNF-α results in an enhanced and sustained IFN and pro-inflammatory cytokine response at the early stage of viral infection that may contribute to the viral pathogenesis and this is of relevance to the design of novel therapeutic strategies for H5N1 induced respiratory disease

A redshift determination of the host galaxy

Using the Suprime-Cam on the Subaru telescope, we carried out deep multi band (V,R, I, z) imaging for the host galaxy of GRB980329, which is one of well studied “optically dark” gamma-ray bursts. The host galaxy was detected clearly in all bands. Combining these measurements with published near-infrared data, we determined the photometric redshift of the galaxy as z = 3.56 (3.21–3.79 at 90 range). The implied V -band extinction is rather low, typically ∼ 1 mag. At z = 3.56, the isotropic 40–700 keV total energy of GRB980329 is calculated as (2.1 ± 0.4) × 1054 erg. Assuming that this GRB was emitted by a pair of jets with a total energy of 1051 ergs, their opening angle is calculated as θj = 2.1. The present results disfavor the high-redshift hypothesis and the high extinction scenario of optically dark bursts