Evidence for Ubiquitous, High-EW Nebular Emission in z~7 Galaxies: Towards a Clean Measurement of the Specific Star Formation Rate using a Sample of Bright, Magnified Galaxies

Growing observational evidence now indicates that nebular line emission has a significant impact on the rest-frame optical fluxes of z~5-7 galaxies observed with Spitzer. This line emission makes z~5-7 galaxies appear more massive, with lower specific star formation rates. However, corrections for this line emission have been very difficult to perform reliably due to huge uncertainties on the overall strength of such emission at z>~5.5. Here, we present the most direct observational evidence yet for ubiquitous high-EW [OIII]+Hbeta line emission in Lyman-break galaxies at z~7, while also presenting a strategy for an improved measurement of the sSFR at z~7. We accomplish this through the selection of bright galaxies in the narrow redshift window z~6.6-7.0 where the IRAC 4.5 micron flux provides a clean measurement of the stellar continuum light. Observed 4.5 micron fluxes in this window contrast with the 3.6 micron fluxes which are contaminated by the prominent [OIII]+Hbeta lines. To ensure a high S/N for our IRAC flux measurements, we consider only the brightest (H_{160}<26 mag) magnified galaxies we have identified in CLASH and other programs targeting galaxy clusters. Remarkably, the mean rest-frame optical color for our bright seven-source sample is very blue, [3.6]-[4.5]=-0.9+/-0.3. Such blue colors cannot be explained by the stellar continuum light and require that the rest-frame EW of [OIII]+Hbeta be greater than 637 Angstroms for the average source. The bluest four sources from our seven-source sample require an even more extreme EW of 1582 Angstroms. Our derived lower limit for the mean [OIII]+Hbeta EW could underestimate the true EW by ~2x based on a simple modeling of the redshift distribution of our sources. We can also set a robust lower limit of >~4 Gyr^-1 on the specific star formation rates based on the mean SED for our seven-source sample. (abridged)Comment: 9 pages, 6 figures, 1 table, submitted to the Astrophysical Journa

The 2017 May 20th^{\rm th} stellar occultation by the elongated centaur (95626) 2002 GZ32_{32}

We predicted a stellar occultation of the bright star Gaia DR1 4332852996360346368 (UCAC4 385-75921) (m$_{\rm V}$= 14.0 mag) by the centaur 2002 GZ$_{32}$ for 2017 May 20$^{\rm th}$. Our latest shadow path prediction was favourable to a large region in Europe. Observations were arranged in a broad region inside the nominal shadow path. Series of images were obtained with 29 telescopes throughout Europe and from six of them (five in Spain and one in Greece) we detected the occultation. This is the fourth centaur, besides Chariklo, Chiron and Bienor, for which a multi-chord stellar occultation is reported. By means of an elliptical fit to the occultation chords we obtained the limb of 2002 GZ$_{32}$ during the occultation, resulting in an ellipse with axes of 305 $\pm$ 17 km $\times$ 146 $\pm$ 8 km. From this limb, thanks to a rotational light curve obtained shortly after the occultation, we derived the geometric albedo of 2002 GZ$_{32}$ ($p_{\rm V}$ = 0.043 $\pm$ 0.007) and a 3-D ellipsoidal shape with axes 366 km $\times$ 306 km $\times$ 120 km. This shape is not fully consistent with a homogeneous body in hydrostatic equilibrium for the known rotation period of 2002 GZ$_{32}$. The size (albedo) obtained from the occultation is respectively smaller (greater) than that derived from the radiometric technique but compatible within error bars. No rings or debris around 2002 GZ$_{32}$ were detected from the occultation, but narrow and thin rings cannot be discarded.Comment: Accepted for publication in MNRAS (8-Dec.-2020), 15 pages, 9 figure

The miniJPAS survey: clusters and galaxy groups detection with AMICO

Samples of galaxy clusters allow us to better understand the physics at play in galaxy formation and to constrain cosmological models once their mass, position (for clustering studies) and redshift are known. In this context, large optical data sets play a crucial role. We investigate the capabilities of the Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS) in detecting and characterizing galaxy groups and clusters. We analyze the data of the miniJPAS survey, obtained with the JPAS-Pathfinder camera and covering $1$ deg$^2$ centered on the AEGIS field to the same depths and with the same 54 narrow band plus 2 broader band near-UV and near-IR filters anticipated for the full J-PAS survey. We use the Adaptive Matched Identifier of Clustered Objects (AMICO) to detect and characterize groups and clusters of galaxies down to $S/N=2.5$ in the redshift range $0.05<z<0.8$. We detect 80, 30 and 11 systems with signal-to-noise ratio larger than 2.5, 3.0 and 3.5, respectively, down to $\sim 10^{13}\,M_{\odot}/h$. We derive mass-proxy scaling relations based on Chandra and XMM-Newton X-ray data for the signal amplitude returned by AMICO, the intrinsic richness and a new proxy that incorporates the galaxies' stellar masses. The latter proxy is made possible thanks to the J-PAS filters and shows a smaller scatter with respect to the richness. We fully characterize the sample and use AMICO to derive a probabilistic membership association of galaxies to the detected groups that we test against spectroscopy. We further show how the narrow band filters of J-PAS provide a gain of up to 100% in signal-to-noise ratio in detection and an uncertainty on the redshift of clusters of only $\sigma_z=0.0037(1+z)$ placing J-PAS in between broadband photometric and spectroscopic surveys. The performances of AMICO and J-PAS with respect to mass sensitivity, mass-proxies qualityComment: 15 pages, 12 figures, 3 tables, submitted to A&

Synapse Clusters Are Preferentially Formed by Synapses with Large Recycling Pool Sizes

Synapses are distributed heterogeneously in neural networks. The relationship between the spatial arrangement of synapses and an individual synapse's structural and functional features remains to be elucidated. Here, we examined the influence of the number of adjacent synapses on individual synaptic recycling pool sizes. When measuring the discharge of the styryl dye FM1–43 from electrically stimulated synapses in rat hippocampal tissue cultures, a strong positive correlation between the number of neighbouring synapses and recycling vesicle pool sizes was observed. Accordingly, vesicle-rich synapses were found to preferentially reside next to neighbours with large recycling pool sizes. Although these synapses with large recycling pool sizes were rare, they were densely arranged and thus exhibited a high amount of release per volume. To consolidate these findings, functional terminals were marked by live-cell antibody staining with anti-synaptotagmin-1-cypHer or overexpression of synaptopHluorin. Analysis of synapse distributions in these systems confirmed the results obtained with FM 1–43. Our findings support the idea that clustering of synapses with large recycling pool sizes is a distinct developmental feature of newly formed neural networks and may contribute to functional plasticity

Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort

Objectives:We utilized the database of the Defining Antibiotic Levels in Intensive care unit patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and clinical outcomes between prolonged-infusion and intermittent-bolus dosing of piperacillin/tazobactam and meropenem in critically ill patients using inclusion criteria similar to those used in previous prospective studies.Methods: This was a post hoc analysis of a prospective, multicentre pharmacokinetic point-prevalence study (DALI), which recruited a large cohort of critically ill patients from 68 ICUs across 10 countries.Results: Of the 211 patients receiving piperacillin/tazobactam and meropenem in the DALI study, 182 met inclusion criteria. Overall, 89.0% (162/182) of patients achieved the most conservative target of 50% fT(&gt; MIC) (time over which unbound or free drug concentration remains above the MIC). Decreasing creatinine clearance and the use of prolonged infusion significantly increased the PTA for most pharmacokinetic/pharmacodynamic targets. In the subgroup of patients who had respiratory infection, patients receiving beta-lactams via prolonged infusion demonstrated significantly better 30 day survival when compared with intermittent-bolus patients [86.2% (25/29) versus 56.7% (17/30); P=0.012]. Additionally, in patients with a SOFA score of &gt;= 9, administration by prolonged infusion compared with intermittent-bolus dosing demonstrated significantly better clinical cure [73.3% (11/15) versus 35.0% (7/20); P=0.035] and survival rates [73.3% (11/15) versus 25.0% (5/20); P=0.025].Conclusions: Analysis of this large dataset has provided additional data on the niche benefits of administration of piperacillin/tazobactam and meropenem by prolonged infusion in critically ill patients, particularly for patients with respiratory infections

Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies

<p>Abstract</p> <p>Background</p> <p>Rectal administration of artemisinin derivatives has potential for early treatment for severe malaria in remote settings where injectable antimalarial therapy may not be feasible. Preparations available include artesunate, artemisinin, artemether and dihydroartemisinin. However each may have different pharmacokinetic properties and more information is needed to determine optimal dose and comparative efficacy with each another and with conventional parenteral treatments for severe malaria.</p> <p>Methods</p> <p>Individual patient data from 1167 patients in 15 clinical trials of rectal artemisinin derivative therapy (artesunate, artemisinin and artemether) were pooled in order to compare the rapidity of clearance of <it>Plasmodium falciparum </it>parasitaemia and the incidence of reported adverse events with each treatment. Data from patients who received comparator treatment (parenteral artemisinin derivative or quinine) were also included. Primary endpoints included percentage reductions in parasitaemia at 12 and 24 hours. A parasite reduction of >90% at 24 hours was defined as parasitological success.</p> <p>Results</p> <p>Artemisinin and artesunate treatment cleared parasites more rapidly than parenteral quinine during the first 24 hours of treatment. A single higher dose of rectal artesunate treatment was five times more likely to achieve >90% parasite reductions at 24 hours than were multiple lower doses of rectal artesunate, or a single lower dose administration of rectal artemether.</p> <p>Conclusion</p> <p>Artemisinin and artesunate suppositories rapidly eliminate parasites and appear to be safe. There are less data on artemether and dihydroartemisinin suppositories. The more rapid parasite clearance of single high-dose regimens suggests that achieving immediate high drug concentrations may be the optimal strategy.</p

Identification of Novel Functional Inhibitors of Acid Sphingomyelinase

We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to treat diseases associated with enhanced activity of ASM, such as Alzheimer's disease, major depression, radiation- and chemotherapy-induced apoptosis and endotoxic shock syndrome. Residual activity of ASM measured in the presence of 10 µM drug concentration shows a bimodal distribution; thus the tested drugs can be classified into two groups with lower and higher inhibitory activity. All FIASMAs share distinct physicochemical properties in showing lipophilic and weakly basic properties. Hierarchical clustering of Tanimoto coefficients revealed that FIASMAs occur among drugs of various chemical scaffolds. Moreover, FIASMAs more frequently violate Lipinski's Rule-of-Five than compounds without effect on ASM. Inhibition of ASM appears to be associated with good permeability across the blood-brain barrier. In the present investigation, we developed a novel structure-property-activity relationship by using a random forest-based binary classification learner. Virtual screening revealed that only six out of 768 (0.78%) compounds of natural products functionally inhibit ASM, whereas this inhibitory activity occurs in 135 out of 2028 (6.66%) drugs licensed for medical use in humans