Malmquist Bias and the Distance to the Virgo Cluster

This paper investigates the impact of Malmquist bias on the distance to the Virgo cluster determined by the H_0 Key Project using M100, and consequently on the derived value of H_0. Malmquist bias is a volume-induced statistical effect which causes the most probable distance to be different from the raw distance measured. Consideration of the bias in the distance to the Virgo cluster raises this distance and lowers the calculated value of H_0. Monte Carlo simulations of the cluster have been run for several possible distributions of spirals within the cluster and of clusters in the local universe. Simulations consistent with known information regarding the cluster and the errors of measurement result in a bias of about 6.5%-8.5%. This corresponds to an unbiased distance of 17.2-17.4 Mpc and a value of H_0 in the range 80-82 km/s/Mpc. The problem of determining the bias to Virgo illustrates several key points regarding Malmquist bias. Essentially all conventional astronomical distance measurements are subject to this bias. In addition, the bias accumulates when an attempt is made to construct "distance ladders" from measurements which are individually biased. As will be shown in the case of Virgo, the magnitude and direction of the bias are sensitive to the spatial distribution of the parent poputation from which the observed object is drawn - a distribution which is often poorly known. This leads to uncertainty in the magnitude of the bias, and adds to the importance of minimizing the number of steps in "distance ladders".Comment: 19 pages, 3 figures, Latex, To appear in Ap

Observation of Parity Nonconservation in Møller Scattering

We report a measurement of the parity-violating asymmetry in fixed target electron-electron (Møller) scattering: A_(PV) = [-175 ± 30(stat)± 20(syst)] X 10^(-9). This first direct observation of parity nonconservation in Møller scattering leads to a measurement of the electron’s weak charge at low energy Q^e_W = -0:053 ± 0:011. This is consistent with the standard model expectation at the current level of precision: sin^2θ_W = (M_Z)_(MS) = 0:2293 ± 0:0024(stat) ± 0:0016(syst) ± 0:0006(theory)

Non-Thermal Continuum toward SGRB2(N-LMH)

An analysis of continuum antenna temperatures observed in the Green Bank Telescope (GBT) spectrometer bandpasses is presented for observations toward SgrB2(N-LMH). Since 2004, we have identified four new prebiotic molecules toward this source by means of rotational transitions between low energy levels; concurrently, we have observed significant continuum in the GBT spectrometer bandpasses centered at 85 different frequencies in the range of 1 to 48 GHz. The continuum heavily influences the molecular spectral features since we have observed far more absorption lines than emission lines for each of these new molecular species. Hence, it is important to understand the nature, distribution, and intensity of the underlying continuum in the GBT bandpasses for the purposes of radiative transfer, i.e. the means by which reliable molecular abundances are estimated. We find that the GBT spectrometer bandpass continuum is consistent with optically-thin, non thermal (synchrotron) emission with a flux density spectral index of -0.7 and a Gaussian source size of ~143" at 1 GHz that decreases with increasing frequency as nu^(-0.52). Some support for this model is provided by high frequency Very Large Array (VLA) observations of SgrB2.Comment: Accepted for Publication in the Astrophysical Journal Letter

Optimal eavesdropping on QKD without quantum memory

We consider the security of the BB84, six-state and SARG04 quantum key distribution protocols when the eavesdropper doesn't have access to a quantum memory. In this case, Eve's most general strategy is to measure her ancilla with an appropriate POVM designed to take advantage of the post-measurement information that will be released during the sifting phase of the protocol. After an optimization on all the parameters accessible to Eve, our method provides us with new bounds for the security of six-state and SARG04 against a memoryless adversary. In particular, for the six-state protocol we show that the maximum QBER for which a secure key can be extracted is increased from 12.6% (for collective attacks) to 20.4% with the memoryless assumption.Comment: 7 pages, 3 figures. Analysis of six-state and SARG04 QKD protocols adde

Mismatch-based delayed thrombolysis: a meta-analysis

<p><b>Background and Purpose</b>: Clinical benefit from thrombolysis is reduced as stroke onset to treatment time increases. The use of "mismatch" imaging to identify patients for delayed treatment has face validity and has been used in case series and clinical trials. We undertook a meta-analysis of relevant trials to examine whether present evidence supports delayed thrombolysis among patients selected according to mismatch criteria.</p> <p><b>Methods</b>: We collated outcome data for patients who were enrolled after 3 hours of stroke onset in thrombolysis trials and had mismatch on pretreatment imaging. We selected the trials on the basis of a systematic search of the Web of Knowledge. We compared favorable outcome, reperfusion and/or recanalization, mortality, and symptomatic intracerebral hemorrhage between the thrombolyzed and nonthrombolyzed groups of patients and the probability of a favorable outcome among patients with successful reperfusion and clinical findings for 3 to 6 versus 6 to 9 hours from poststroke onset. Results are expressed as adjusted odds ratios (a-ORs) with 95% CIs. Heterogeneity was explored by test statistics for clinical heterogeneity, I2 (inconsistency), and L’Abbé plot.</p> <p><b>Results</b>: We identified articles describing the DIAS, DIAS II, DEDAS, DEFUSE, and EPITHET trials, giving a total of 502 mismatch patients thrombolyzed beyond 3 hours. The combined a-ORs for favorable outcomes were greater for patients who had successful reperfusion (a-OR=5.2; 95% CI, 3 to 9; I2=0%). Favorable clinical outcome was not significantly improved by thrombolysis (a-OR=1.3; 95% CI, 0.8 to 2.0; I2=20.9%). Odds for reperfusion/recanalization were increased among patients who received thrombolytic therapy (a-OR=3.0; 95% CI, 1.6 to 5.8; I2=25.7%). The combined data showed a significant increase in mortality after thrombolysis (a-OR=2.4; 95% CI, 1.2 to 4.9; I2=0%), but this was not confirmed when we excluded data from desmoteplase doses that were abandoned in clinical development (a-OR=1.6; 95% CI, 0.7 to 3.7; I2=0%). Symptomatic intracerebral hemorrhage was significantly increased after thrombolysis (a-OR=6.5; 95% CI, 1.2 to 35.4; I2=0%) but not significant after exclusion of abandoned doses of desmoteplase (a-OR=5.4; 95% CI, 0.9 to 31.8; I2=0%).</p> <p><b>Conclusions</b>: Delayed thrombolysis amongst patients selected according to mismatch imaging is associated with increased reperfusion/recanalization. Recanalization/reperfusion is associated with improved outcomes. However, delayed thrombolysis in mismatch patients was not confirmed to improve clinical outcome, although a useful clinical benefit remains possible. Thrombolysis carries a significant risk of symptomatic intracerebral hemorrhage and possibly increased mortality. Criteria to diagnose mismatch are still evolving. Validation of the mismatch selection paradigm is required with a phase III trial. Pending these results, delayed treatment, even according to mismatch selection, cannot be recommended as part of routine care.</p&gt

Cosmic microwave background anisotropies in the CDM model: a covariant and gauge-invariant approach

We present a fully covariant and gauge-invariant calculation of the evolution of anisotropies in the cosmic microwave background (CMB) radiation. We use the physically appealing covariant approach to cosmological perturbations, which ensures that all variables are gauge-invariant and have a clear physical interpretation. We derive the complete set of frame-independent, linearised equations describing the (Boltzmann) evolution of anisotropy and inhomogeneity in an almost Friedmann-Robertson-Walker (FRW) cold dark matter (CDM) universe. These equations include the contributions of scalar, vector and tensor modes in a unified manner. Frame-independent equations for scalar and tensor perturbations, which are valid for any value of the background curvature, are obtained straightforwardly from the complete set of equations. We discuss the scalar equations in detail, including the integral solution and relation with the line of sight approach, analytic solutions in the early radiation dominated era, and the numerical solution in the standard CDM model. Our results confirm those obtained by other groups, who have worked carefully with non-covariant methods in specific gauges, but are derived here in a completely transparent fashion.Comment: Two new sections added to earlier version. To appear in Astrophys.

Light Assisted Collisional Loss in a 85/87^{85/87}Rb Ultracold Optical Trap

We have studied hetero- and homonuclear excited state/ground state collisions by loading both $^{85}$Rb and $^{87}$Rb into a far off resonant trap (FORT). Because of the relatively weak confinement of the FORT, we expect the hyperfine structure of the different isotopes to play a crucial role in the collision rates. This dependence on hyperfine structure allows us to measure collisions associated with long range interatomic potentials of different structure: such as long and short ranged; or such as purely attractive, purely repulsive, or mixed attractive and repulsive. We observe significantly different loss rates for different excited state potentials. Additionally, we observe that some collisional channels' loss rates are saturated at our operating intensities (~15 mW/cm$^{2}$). These losses are important limitations in loading dual isotope optical traps.Comment: about 8 pages, 5 figure