Tuning the DNA Reactivity of cis-Platinum: Conjugation to a Mismatch-Specific Metallointercalator

A novel bimetallic conjugate combining a rhodium intercalator that selectively binds DNA mismatches and a reactive cis-platinum analogue that targets DNA by coordination has been prepared. The site-selectivity of the bimetallic complex in forming coordination adducts is examined using mismatched and well-matched oligonucleotides of different sequences. The results indicate that through the bifunctional complex, the platinum center can be targeted near mismatched sites. Interestingly, with mismatched, DNA both intrastrand and the less common interstrand cross-linked adducts are formed. The recognition of a DNA mismatch by the bulky Rh intercalator appears to direct the Pt unit, depending upon steric constraints, to react preferentially with mismatched DNA at a site that may or may not be the preferred site of Pt coordination. Thus, the presence of a permanent link to a site-specific intercalator is able to tune the reactivity of the cis-platinum analogue

High resolution study of associated C IV absorption systems in NGC 5548

We present the results of a careful analysis of associated absorption systems toward NGC 5548. Most of the well resolved narrow components in the associated system, defined by the Lyman alpha, C IV and N V profiles, show velocity separation similar (to within 10~\kms) to the C IV doublet splitting. We estimate the chance probability of occurrence of such pairs with velocity separation equal to C IV doublet splitting to be $6\times10^{-3}$. Thus it is more likely that most of the narrow components are line-locked with C IV doublet splitting. This will mean that the radiative acceleration plays an important role in the kinematics of the absorbing clouds. We build grids of photoionization models and estimate the radiative acceleration due to all possible bound-bound transitions. We show that the clouds producing absorption have densities less than $10^9 cm^{-3}$, and are in the outer regions of the broad emission line region (BLR). We note that the clouds which are line-locked cannot produce appreciable optical depths of O VII and O VIII, and hence cannot be responsible for the observed ionized edges, in the soft X-ray. We discuss the implications of the presence of optically thin clouds in the outer regions of the BLR to the models of broad emission lines.Comment: 21 pages, latex (aasms4 style), incluedes 4 ps figures. To appear in Astrophysical Journa

Semiclassical approach to the ac-conductance of chaotic cavities

We address frequency-dependent quantum transport through mesoscopic conductors in the semiclassical limit. By generalizing the trajectory-based semiclassical theory of dc quantum transport to the ac case, we derive the average screened conductance as well as ac weak-localization corrections for chaotic conductors. Thereby we confirm respective random matrix results and generalize them by accounting for Ehrenfest time effects. We consider the case of a cavity connected through many leads to a macroscopic circuit which contains ac-sources. In addition to the reservoir the cavity itself is capacitively coupled to a gate. By incorporating tunnel barriers between cavity and leads we obtain results for arbitrary tunnel rates. Finally, based on our findings we investigate the effect of dephasing on the charge relaxation resistance of a mesoscopic capacitor in the linear low-frequency regime

The Origin of C IV Absorption Systems at Redshifts z<1---Discovery of Extended C IV Envelopes Around Galaxies

(Abridged) We report the discovery of extended CIV gaseous envelopes around galaxies of a wide range of luminosity and morphological type. First, we show that CIV absorption systems are strongly clustered around galaxies on velocity scales of v < 250 km/s and impact parameter scales of rho < 100 h^{-1} kpc but not on larger velocity or impact parameter scales. Next, adopting measurements of galaxy properties presented in previous papers, we examine how properties of the CIV absorption systems depend on properties of the galaxies. On the basis of 14 galaxy and absorber pairs and 36 galaxies that do not produce corresponding CIV absorption lines to within sensitive upper limits, we find that: (1) Galaxies of a range of morphological type and luminosity appear to possess extended CIV gaseous envelopes of radius R ~ 100 h^{-1} kpc, with abrupt boundaries between the CIV absorbing and non-absorbing regions. (2) The extent of CIV-absorbing gas around galaxies scales with galaxy B-band luminosity as R \propto L_B^{0.5 +/- 0.1} but does not depend strongly on galaxy surface brightness, redshift, or morphological type. And (3) the covering factor of CIV clouds within ~ 100 h^{-1} kpc of galaxies is nearly unity, but there is a large scatter in the mean number of clouds encountered along the line of sight. The most significant implication of the study is that galaxies of a wide range of luminosity and morphological type are surrounded by chemically enriched gas that extends for at least ~ 100 h^{-1} kpc. We consider various scenarios that may have produced metals at large galactic distance and conclude that accreting satellites are most likely to be responsible for chemically enriched gas at large galactic distances to regular looking galaxies.Comment: 19 pages, 3 figures, to appear in ApJ, July 20 200

Incidence of HI 21-cm absorption in strong FeII systems at 0.5<z<1.50.5<z<1.5

We present the results from our search for HI 21-cm absorption in a sample of 16 strong FeII systems ($W_{\rm r}$(MgII $\lambda2796$) $\ge1.0$ \AA\ and $W_{\rm r}$(FeII $\lambda2600$) or $W_{\rm FeII}$ $\ge1$ \AA) at $0.5<z<1.5$ using the Giant Metrewave Radio Telescope and the Green Bank Telescope. We report six new HI 21-cm absorption detections from our sample, which have increased the known number of detections in strong MgII systems at this redshift range by $\sim50$%. Combining our measurements with those in the literature, we find that the detection rate of HI 21-cm absorption increases with $W_{\rm FeII}$, being four times higher in systems with $W_{\rm FeII}$ $\ge1$ \AA\ compared to systems with $W_{\rm FeII}$ $<1$ \AA. The $N$(HI) associated with the HI 21-cm absorbers would be $\ge 2 \times 10^{20}$ cm$^{-2}$, assuming a spin temperature of $\sim500$ K (based on HI 21-cm absorption measurements of damped Lyman-$\alpha$ systems at this redshift range) and unit covering factor. We find that HI 21-cm absorption arises on an average in systems with stronger metal absorption. We also find that quasars with HI 21-cm absorption detected towards them have systematically higher $E(B-V)$ values than those which do not. Further, by comparing the velocity widths of HI 21-cm absorption lines detected in absorption- and galaxy-selected samples, we find that they show an increasing trend (significant at $3.8\sigma$) with redshift at $z<3.5$, which could imply that the absorption originates from more massive galaxy haloes at high-$z$. Increasing the number of HI 21-cm absorption detections at these redshifts is important to confirm various trends noted here with higher statistical significance.Comment: 17 pages, 10 figures, 8 tables, accepted for publication in MNRA

The Advantage of Increased Resolution in the Study of Quasar Absorption Systems

We compare a new R = 120,000 spectrum of PG1634+706 (z_QSO = 1.337,m_V = 14.9) obtained with the HDS instrument on Subaru to a R = 45, 000 spectrum obtained previously with HIRES/Keck. In the strong MgII system at z = 0.9902 and the multiple cloud, weak MgII system at z = 1.0414, we find that at the higher resolution, additional components are resolved in a blended profile. We find that two single-cloud weak MgII absorbers were already resolved at R = 45,000, to have b = 2 - 4 km/s. The narrowest line that we measure in the R = 120, 000 spectrum is a component of the Galactic NaI absorption, with b = 0.90+/-0.20 km/s. We discuss expectations of similarly narrow lines in various applications, including studies of DLAs, the MgI phases of strong MgII absorbers, and high velocity clouds. By applying Voigt profile fitting to synthetic lines, we compare the consistency with which line profile parameters can be accurately recovered at R = 45,000 and R = 120,000. We estimate the improvement gained from superhigh resolution in resolving narrowly separated velocity components in absorption profiles. We also explore the influence of isotope line shifts and hyperfine splitting in measurements of line profile parameters, and the spectral resolution needed to identify these effects. Super high resolution spectra of quasars, which will be routinely possible with 20-meter class telescopes, will lead to greater sensitivity for absorption line surveys, and to determination of more accurate physical conditions for cold phases of gas in various environments.Comment: To appear in AJ. Paper with better resolution images available at http://www.astro.psu.edu/users/anand/superhigh.AJ.pd

The Ucsd/Keck Damped Lya Abundance Database: A Decade of High Resolution Spectroscopy

We publish the Keck/HIRES and Keck/ESI spectra that we have obtained during the first 10 years of Keck observatory operations. Our full sample includes 42 HIRES spectra and 39 ESI spectra along 65 unique sightlines providing abundance measurements on ~85 damped Lya systems. The normalized data can be downloaded from the journal or from our supporting website: http://www.ucolick.org/~xavier/DLA/. The database includes all of the sightlines that have been included in our papers on the chemical abundances, kinematics, and metallicities of the damped Lya systems. This data has also been used to argue for variations in the fine-structure constant. We present new chemical abundance measurements for 10 damped Lya systems and a summary table of high-resolution metallicity measurements (including values from the literature) for 153 damped Lya systems at z>1.6. We caution, however, that this metallicity sample (and all previous ones) is biased to higher N(HI) values than a random sample.Comment: 55 pages, 11 figures. Accepted to ApJS. See http://www.ucolick.org/~xavier/DLA/ for the dat

The X-ray nebula around the Seyfert 2 galaxy NGC4388

We report on X-ray emission from the Seyfert 2 galaxy NGC4388 observed with the Chandra X-ray Observatory. A hard X-ray peak is found at the position of the active nucleus suggested by optical and radio observations. Extended soft X-ray emission correlates well with the ionization cone found in optical line emission. A large soft X-ray extension is found up to 16 kpc to the north of the galaxy. Photoionized gas with low ionization parameters (xi<3) appears to be the likely explanation of this emission. The same ionized gas clouds could be responsible for the optical [OIII] emission. Fe K line emission from cold material is found to be extended by a few kpc.Comment: 12 pages, one colour figure included, MNRAS in pres

Broad P V Absorption in the BALQSO, PG 1254+047: Column Densities, Ionizations and Metal Abundances in BAL Winds

This paper discusses the detection of P V 1118,1128 and other broad absorption lines (BALs) in archival HST spectra of the low-redshift BALQSO, PG 1254+047. The P V identification is secured by excellent redshift and profile coincidences with the other BALs, such as C IV 1548,1550 and Si IV 1393,1403, and by photoionization calculations showing that other lines near this wavelength, e.g. Fe III 1123, should be much weaker than P V. The observed BAL strengths imply that either 1) there are extreme abundance ratios such as [C/H] >~ +1.0, [Si/H] >~ +1.8 and [P/C] >~ +2.2, or 2) at least some of the lines are much more optically thick than they appear. I argue that the significant presence of P V absorption indicates severe line saturation, which is disguised in the observed (moderate-strength) BALs because the absorber does not fully cover the continuum source(s) along our line(s) of sight. Computed optical depths for all UV resonance lines show that the observed BALs are consistent with solar abundances if 1) the ionization parameter is at least moderately high, log U >~ -0.6, 2) the total hydrogen column density is log N_H(cm-2) >~ 22.0, and 3) the optical depths in strong lines like C IV and O VI 1032,1038 are >~25 and >~80, respectively. These optical depths and column densities are at least an order of magnitude larger than expected from the residual intensities in the BAL troughs, but they are consistent with the large absorbing columns derived from X-ray observations of BALQSOs. The outflowing BALR, at velocities from -15,000 to -27,000 km/s in PG 1254+047, is therefore a strong candidate for the X-ray absorber in BALQSOs.Comment: 16 pages (LaTeX) plus 8 pages of figures in one file (pg1254_figs.ps.gz), in press with Ap

Cosmological Bounds on Spatial Variations of Physical Constants

We derive strong observational limits on any possible large-scale spatial variation in the values of physical 'constants' whose space-time evolution is driven by a scalar field. The limits are imposed by the isotropy of the microwave background on large angular scales in theories which describe space and time variations in the fine structure constant, the electron-proton mass ratio, and the Newtonian gravitational constant, G. Large-scale spatial fluctuations in the fine structure constant are bounded by 2x10^-9 and 1.2x10^-8 in the BSBM and VSL theories respectively, fluctuations in the electron-proton mass ratio by 9x10^-5 in the BM theory and fluctuations in G by 3.6x10^-10 in Brans-Dicke theory. These derived bounds are significantly stronger than any obtainable by direct observations of astrophysical objects at the present time.Comment: 13 pages, 1 table, typos corrected, refs added. Published versio