Bloat in Ruminants: The Cell Rupture Hypothesis

An alfalfa (Medicago sativa L.) cultivar with a low initial rate of digestion (LIRD), AC Grazeland B, was developed to test the hypothesis that the rate of cell rupture was a cause of frothy bloat in cattle or sheep. The amount of cell wall increases and digestibility declines as plants mature. Thus the cell rupture theory also predicts that the bloat potential of alfalfa is related to maturity. This study compared the digestibility of cell walls (NDF) in LIRD cultivars with that of a standard, Beaver, in relation to maturity and bloat incidence. Fresh alfalfa was fed to wethers during two experiments. NDF was greater (P#.05) in Beaver (43.9%) than the less mature LIRD cultivar (41.1%) during Experiment 1. The digestibility of NDF was greater (P#.05) in the LIRD cultivar (48.4%; Beaver = 44.5%) during Experiment 2, when both cultivars were in vegetative stages of development but NDF digestibility was lower (P#.05) when the cultivars had matured to the bud stage (LIRD=37.1%; Beaver=48.4%). Bloat incidence did not differ between cultivars at the same stage of development. The number of bloats declined as the alfalfa matured, an effect which was attributed to the barrier to microbial invasion created by increasing amounts of cell wall and reduced cell wall digestibility. The cell rupture hypothesis of frothy bloat was supported by these results demonstrating that alfalfa maturity plays a key role in bloat etiology

Bacterial Cholangitis, Cholecystitis, or both in Dogs

BACKGROUND: Bacterial cholangitis and cholecystitis are rarely reported, poorly characterized diseases in the dog. OBJECTIVES: To characterize the clinical features of these conditions. ANIMALS: Twenty‐seven client‐owned dogs with bacterial cholangitis, cholecystitis, or both. METHODS: Multicenter, retrospective cases series of dogs with bacterial cholangitis, cholecystitis, or both, presenting January 2000 to June 2011 to 4 Veterinary Schools in Ireland/United Kingdom. Interrogation of hospital databases identified all cases with the inclusion criteria; histopathologically confirmed cholangitis or cholecystitis and bile culture/cytology results supporting a bacterial etiology. RESULTS: Twenty‐seven dogs met the inclusion criteria with approximately 460 hepatitis cases documented over the same study period. Typical clinical pathology findings were increases in liver enzyme activities (25/26), hyperbilirubinemia (20/26), and an inflammatory leukogram (21/24). Ultrasound findings, although nonspecific, aided decision‐making in 25/26 cases. The most frequent hepatobiliary bacterial isolates were Escherichia coli (n = 17; 16 cases), Enterococcus spp. (n = 8; 6 cases), and Clostridium spp. (n = 5; 5 cases). Antimicrobial resistance was an important feature of aerobic isolates; 10/16 E. coli isolates resistant to 3 or more antimicrobial classes. Biliary tract rupture complicated nearly one third of cases, associated with significant mortality (4/8). Discharged dogs had a guarded to fair prognosis; 17/18 alive at 2 months, although 5/10 re‐evaluated had persistent liver enzyme elevation 2–12 months later. CONCLUSION AND CLINICAL SIGNIFICANCE: Bacterial cholangitis and cholecystitis occur more frequently than suggested by current literature and should be considered in dogs presenting with jaundice and fever, abdominal pain, or an inflammatory leukogram or with ultrasonographic evidence of gallbladder abnormalities

An experimental evaluation of software redundancy as a strategy for improving reliability

The strategy of using multiple versions of independently developed software as a means to tolerate residual software design faults is suggested by the success of hardware redundancy for tolerating hardware failures. Although, as generally accepted, the independence of hardware failures resulting from physical wearout can lead to substantial increases in reliability for redundant hardware structures, a similar conclusion is not immediate for software. The degree to which design faults are manifested as independent failures determines the effectiveness of redundancy as a method for improving software reliability. Interest in multi-version software centers on whether it provides an adequate measure of increased reliability to warrant its use in critical applications. The effectiveness of multi-version software is studied by comparing estimates of the failure probabilities of these systems with the failure probabilities of single versions. The estimates are obtained under a model of dependent failures and compared with estimates obtained when failures are assumed to be independent. The experimental results are based on twenty versions of an aerospace application developed and certified by sixty programmers from four universities. Descriptions of the application, development and certification processes, and operational evaluation are given together with an analysis of the twenty versions

An experimental study of the rearrangements of valence protons and neutrons amongst single-particle orbits during double {\beta} decay in 100Mo

The rearrangements of protons and neutrons amongst the valence single-particle orbitals during double {\beta} decay of 100Mo have been determined by measuring cross sections in (d,p), (p,d), (3He,{\alpha}) and (3He,d) reactions on 98,100Mo and 100,102Ru targets. The deduced nucleon occupancies reveal significant discrepancies when compared with theoretical calculations; the same calculations have previously been used to determine the nuclear matrix element associated with the decay probability of double {\beta} decay of the 100Mo system.Comment: 18 pages, 13 figures, 37 pages of supplemental informatio

The Relationship of Coronal Mass Ejections to Streamers

We have examined images from the Large Angle Spectroscopic Coronagraph (LASCO) to study the relationship of Coronal Mass Ejections (CMEs) to coronal streamers. We wish to test the suggestion (Low 1996) that CMEs arise from flux ropes embedded in a streamer erupting, thus disrupting the streamer. The data span a period of two years near sunspot minimum through a period of increased activity as sunspot numbers increased. We have used LASCO data from the C2 coronagraph which records Thomson scattered white light from coronal electrons at heights between 1.5 and 6R_sun. Maps of the coronal streamers have been constructed from LASCO C2 observations at a height of 2.5R_sun at the east and west limbs. We have superposed the corresponding positions of CMEs observed with the C2 coronagraph onto the synoptic maps. We identified the different kinds of signatures CMEs leave on the streamer structure at this height (2.5R_sun). We find four types of CMEs with respect to their effect on streamers: 1. CMEs that disrupt the streamer 2. CMEs that have no effect on the streamer, even though they are related to it. 3. CMEs that create streamer-like structures 4. CMEs that are latitudinally displaced from the streamer. This is the most extensive observational study of the relation between CMEs and streamers to date. Previous studies using SMM data have made the general statement that CMEs are mostly associated with streamers, and that they frequently disrupt it. However, we find that approximately 35% of the observed CMEs bear no relation to the pre-existing streamer, while 46% have no effect on the observed streamer, even though they appear to be related to it. Our conclusions thus differ considerably from those of previous studies.Comment: Accepted, Journal of Geophysical Research. 8 figs, better versions at http://www.science.gmu.edu/~prasads/streamer.htm

Oscillations in the bispectrum

There exist several models of inflation that produce primordial bispectra that contain a large number of oscillations. In this paper we discuss these models, and aim at finding a method of detecting such bispectra in the data. We explain how the recently proposed method of mode expansion of bispectra might be able to reconstruct these spectra from separable basis functions. Extracting these basis functions from the data might then lead to observational constraints on these models.Comment: 6 pages, 2 figures, submitted to JOP: Conference Series, PASCOS 201

Altered hippocampal function in major depression despite intact structure and resting perfusion

Background: Hippocampal volume reductions in major depression have been frequently reported. However, evidence for functional abnormalities in the same region in depression has been less clear. We investigated hippocampal function in depression using functional magnetic resonance imaging (fMRI) and neuropsychological tasks tapping spatial memory function, with complementing measures of hippocampal volume and resting blood flow to aid interpretation. Method: A total of 20 patients with major depressive disorder (MDD) and a matched group of 20 healthy individuals participated. Participants underwent multimodal magnetic resonance imaging (MRI): fMRI during a spatial memory task, and structural MRI and resting blood flow measurements of the hippocampal region using arterial spin labelling. An offline battery of neuropsychological tests, including several measures of spatial memory, was also completed. Results: The fMRI analysis showed significant group differences in bilateral anterior regions of the hippocampus. While control participants showed task-dependent differences in blood oxygen level-dependent (BOLD) signal, depressed patients did not. No group differences were detected with regard to hippocampal volume or resting blood flow. Patients showed reduced performance in several offline neuropsychological measures. All group differences were independent of differences in hippocampal volume and hippocampal blood flow. Conclusions: Functional abnormalities of the hippocampus can be observed in patients with MDD even when the volume and resting perfusion in the same region appear normal. This suggests that changes in hippocampal function can be observed independently of structural abnormalities of the hippocampus in depression

Only the best? Exploring cross-border investor preferences in US gateway cities

Despite heady growth in cross-border investment into commercial real estate over recent decades, there are few studies that examine differences in investment preferences between domestic and cross-border investors at a micro level. We address the gap by examining the characteristics of assets acquired by cross border investors in six major US metro areas, comparing them with the purchases made by US investors in those same areas. Our study uses data on more than 67 500 transactions recorded by Real Capital Analytics (RCA) over the period from Q1 2003 to Q3 2016. As well as examining cross-border investors in aggregate, we isolate and examine purchases by investors from each of the four principal source nations for cross-border real estate investment in these cities. This is important since treating cross-border investors as a single group may obscure important differences between them. We employ multilevel logit techniques and we find across a number of specifications that cross-border investors prefer larger assets, newer assets and CBD locations regardless of nationality. However, temporal and sectoral patterns of investment, as well as evidence for return chasing behavior, vary with the nationality of investor being studied

An Inflaton Mass Problem in String Inflation from Threshold Corrections to Volume Stabilization

Inflationary models whose vacuum energy arises from a D-term are believed not to suffer from the supergravity eta problem of F-term inflation. That is, D-term models have the desirable property that the inflaton mass can naturally remain much smaller than the Hubble scale. We observe that this advantage is lost in models based on string compactifications whose volume is stabilized by a nonperturbative superpotential: the F-term energy associated with volume stabilization causes the eta problem to reappear. Moreover, any shift symmetries introduced to protect the inflaton mass will typically be lifted by threshold corrections to the volume-stabilizing superpotential. Using threshold corrections computed by Berg, Haack, and Kors, we illustrate this point in the example of the D3-D7 inflationary model, and conclude that inflation is possible, but only for fine-tuned values of the stabilized moduli. More generally, we conclude that inflationary models in stable string compactifications, even D-term models with shift symmetries, will require a certain amount of fine-tuning to avoid this new contribution to the eta problem.Comment: 25 page