7 research outputs found
Age for measles immunization seroconversion after measles vaccination at 6-8 months of age - A randomised controlled trial
The, objective of the study was to compare the
effectiveness of measles vaccine by seroconversion
in vaccinated children with non-vaccinated children
of 6 to 8 months age group in a city slam community
so as to study the feasibility of advancing the age
of immunization. Live attenuated lyophilized
Schwartz strain of measles vaccine was used.
Hemagglutination inhibition (HI) antibody was
estimated. Seroconversion was defined as either the
conversion of negative to positive or a two fold rise
in titre. One hundred and thirty two children
completed the study. There was no difference in
the age, sex and nutritional status between vaccinated
and non-vaccinated groups (p>0.7). The
seroconversion rate in the vaccinated group was
65% and in the non-vaccinated group was 26%.
The age, sex and nutritional status did not significantly
affect the seroconversion. Oar data suggest
that immunization with measles vaccine may be
effective as early as 6 months of age. Immunization
at 6 months may be needed at least for children in
densely populated areas like cities and towns
Unique cellular immune signatures of multisystem inflammatory syndrome in children
The clinical presentation of MIS-C overlaps with other infectious/non-infectious diseases such as acute COVID-19, Kawasaki disease, acute dengue, enteric fever, and systemic lupus erythematosus. We examined the ex-vivo cellular parameters with the aim of distinguishing MIS-C from other syndromes with overlapping clinical presentations. MIS-C children differed from children with non-MIS-C conditions by having increased numbers of naïve CD8(+) T cells, naïve, immature and atypical memory B cells and diminished numbers of transitional memory, stem cell memory, central and effector memory CD4(+) and CD8(+) T cells, classical, activated memory B and plasma cells and monocyte (intermediate and non-classical) and dendritic cell (plasmacytoid and myeloid) subsets. All of the above alterations were significantly reversed at 6–9 months post-recovery in MIS-C. Thus, MIS-C is characterized by a distinct cellular signature that distinguishes it from other syndromes with overlapping clinical presentations. Trial Registration: ClinicalTrials.gov clinicaltrial.gov. No: NCT04844242
Prevalence of placentally transmitted antibodies for measles in infants 3 to 11 months old in an urban slum community
Upto 35% of infants aged between 6 and 11
months are infected with measles in India with its
associated high morbidity and mortality. The
objective of the study is to know the waning pattern
of placentally transmitted antibodies (PTA) for
measles so that the age at which children are likely
to become susceptible to measles infection could be
identified. A cross-sectional serological survey
of children aged 3 to 11 months in one of the Integrated
Child Development Service (ICDS) area in
Madras city slums was done. Venous blood from
376 children was collected and was tested for
Hemagglutination Inhibition (HI) antibodies by
standard microtitration technique. Titre > 1:8
has been considered as protective. The proportion
of children with immune level and the Geometric
Mean Titre (GMT), declined to the least by 5
months which denotes that most of the infants
become susceptible to measles infection from as
early as 5 months of age. There is no significant
difference in the waning pattern between different
age groups, sex and nutritional status. A community
study for effectiveness of measles vaccine
at 6-8 months of age is needed to know the feasibility
of immunization earlier than 9 months of age