Effect of intramuscular tramadol hydrochloride as a labor analgesic in primagravidae

Background: Labour pain is among the most severe pain experienced by women. The need for analgesia to overcome pain in labour is highly requested by women today. In developing nations where availability of facilities is the main limiting factor, intramuscular opioids can be considered.Methods: This study was conducted in teaching. 200 low risk primigravidae who fulfilled the selection criteria with full-term pregnancy with vertex presentation with good uterine contractions and already in active phase of labour were given 100 mg tramadol hydrochloride intramuscularly.Results: 200 primigravidae before giving the drug, no patient had grade-I or no pain, 19% had grade-III and 81% had grade-IV pain. After administration of tramadol hydrochloride IM there was reduction of pain from grade-III and grade IV by 52.49% and all of the patients continued with grade-II pain in 2nd stage and delivered normally and only 6 women had minimal side effects like nausea and vomiting.Conclusions: In low risk primigravidae, IM tramadol hydrochloride appears to be effective with minimal side effects. Hence, in developing nations, where availability of facilities is the main limiting factor, IM opioids can be considered as suitable alternatives

A study on effect of tramadol hydrochloride on both mother and newborn in using labor pain

Background: The analgesic efficacy of intramuscular opioids versus epidural analgesia in labor and concluded that the analgesic efficacy and maternal satisfaction is better with epidural analgesia than with opioids.  Hence in developing nations, where availability of facilities is the main limiting factor, intramuscular opioids can be considered suitable alternatives.Methods: A 200 primigravid women presenting with full term pregnancy at a tertiary care center constituted the study subjects.Results: Birth weights of babies’ shows maximum number (65%) of babies have birth weight of 2.5 to 2.9 Kg.  About 28.5% have birth weight between 3 to 3.4 Kg, 6.5% of babies’ have birth weight of 2-2.4 Kg.Conclusions: This Drug has no adverse effects in the mothers/ on to newborn

Ameliorative Effects of Dimetylthiourea and N-Acetylcysteine on Nanoparticles Induced Cyto-Genotoxicity in Human Lung Cancer Cells-A549

We study the ameliorative potential of dimetylthiourea (DMTU), an OH• radical trapper and N-acetylcysteine (NAC), a glutathione precursor/H2O2 scavenger against titanium dioxide nanoparticles (TiO2-NPs) and multi-walled carbon nanotubes (MWCNTs) induced cyto-genotoxicity in cultured human lung cancer cells-A549. Cytogenotoxicity was induced by exposing the cells to selected concentrations (10 and 50 µg/ml) of either of TiO2-NPs or MWCNTs for 24 h. Anti-cytogenotoxicity effects of DMTU and NAC were studied in two groups, i.e., treatment of 30 minutes prior to toxic insult (short term exposure), while the other group received DMTU and NAC treatment during nanoparticles exposure, i.e., 24 h (long term exposure). Investigations were carried out for cell viability, generation of reactive oxygen species (ROS), micronuclei (MN), and expression of markers of oxidative stress (HSP27, CYP2E1), genotoxicity (P53) and CYP2E1 dependent n- nitrosodimethylamine-demethylase (NDMA-d) activity. In general, the treatment of both DMTU and NAC was found to be effective significantly against TiO2-NPs and MWCNTs induced cytogenotoxicity in A549 cells. Long-term treatment of DMTU and NAC during toxic insults has shown better prevention than short-term pretreatment. Although, cells responded significantly to both DMTU and NAC, but responses were chemical specific. In part, TiO2-NPs induced toxic responses were mediated through OH• radicals generation and reduction in the antioxidant defense system. While in the case of MWCNTs, adverse effects were primarily due to altering/hampering the enzymatic antioxidant system. Data indicate the applicability of human lung cancer cells-A549 as a pre-screening tool to identify the target specific prophylactic and therapeutic potential of drugs candidate molecules against nanoparticles induced cellular damages

3rd National Conference on Image Processing, Computing, Communication, Networking and Data Analytics

This volume contains contributed articles presented in the conference NCICCNDA 2018, organized by the Department of Computer Science and Engineering, GSSS Institute of Engineering and Technology for Women, Mysore, Karnataka (India) on 28th April 2018