THE ANTIOXIDATIVE DEFENCE IN WOMEN WITH EXTERNAL ENDOMETRIOSIS

We studied the indexes of antioxidative defence – the concentration of active form of enzymes ceruloplasmin (CP) and transferin (TF) and NO-capacity of the protein of blood in 60 women with external endometriosis by method spectroscopy. The concentration of active form of ceruloplasmin was increased and the concentration of transferin was decreased in women with external endometriosis; the index CP/TF was increased. The NO-connective capacity of theblood was significant increased in this group of women comparing with their relatives and the control (healthy women) group. These changes are the result of the breach of balance in the system oxidant\antioxidant and the development of oxidative stress in this group of women

THE ROLE OF AROMATASE IN THE DEVELOPMENT OF ENDOMETRIOSIS

The purpose of work – improving the efficiency of treating endometriosis by clarifying some aspects of the pathogenesis of endometriosis.Objectives of the study – determining the expression of aromatase in atopicescom and ectopic endometrium, to identify the relationship of polymorphisms in the aromatase gene and gems of detoksikatsii to optimize the ingenious treatment of patients with endometriosis.Materials and methods. Definition of polymorphic gene variants of CYP19 was assessed by PCR with specific oligoprimers with subsequent restriction analysis.Results: the Expression of aromatase in the studied forms of endometriosis is positively correlated with the stage of disease. The "zero" variant of the gene GSTМ associated with pelvic pain of varying intensity, as well as recurrent forms of the disease (χ2 =of 8.78; p<0.05), which is important in the prediction of the clinical course of the disease. By gene GSTT1 any difference in the groups, as well as links with clinical manifestations of endometriosis was obtained.Conclusion. Detection of positive expression of aromatase in the ectopic foci, and also in the endometrium atopicescom when adenomiose (58%) and external endometriosis (80%), its relationship with stage distribution of the disease and the severity of pain allows us to consider this enzyme as a promising for the diagnosis and development of new approaches to the treatment of endometriosis with aromatase inhibitors. The study of associated gene polymorphisms of the aromatase CYP19 and detoxification GSTM can be recommended as a prognostic test for assessing the risk of development and prognosis the clinical course of endometriosis

Current trends in the pharmacotherapy of uterine myoma, associated with heavy menstrual bleeding and anemia: a literature review

Aim: to summarize up-to-date world data on current opportunities of drug therapy in treatment of symptomatic myoma accompanied with heavy menstrual bleeding and anemia.Materials and Methods. A search of publications was carried out in the main international databases published in Russian and English: PubMed/MEDLINE, The Cochrane Library, Embase, and eLibrary. The analysis included studies published over the last 10 years examining the clinical efficacy and safety of various groups of pharmacological agents used for treatment of uterine myoma combined with heavy menstrual bleeding in women of reproductive age.Results. Currently, treatment of uterine fibroids consists of the three major approaches: surgical, minimally invasive organpreserving methods, and pharmacotherapy. Until now, surgical intervention remains the main method of treatment, unfortunately being often performed in a foem of hysterectomy. However, today it is important to apply a personalized approach to the management of a female patient with symptomatic uterine myoma, taking into account her wish to preserve reproductive function. Advances in drug therapy greatly contributed to optimizing management of such patients.Conclusion. Treatment of symptomatic uterine fibroids globally tends to lowering the number of radical interventions, as well as develop and improve new therapeutic approaches for. Currently, pharmacotherapy of leiomyoma can substantially improve the quality of patients' life, lower number of radical surgical interventions, optimize surgical treatment, and even fully negate, in some cases, a need for surgery

MEDICO-GENETIC ASPECTS OF INFERTILITY

Results of medico-genetic examination of 304 married couples with infertility (608 individuals) are presented in article. Frequency of genetic abnormalities and infertility structure are revealed. Comparative analysis between 2 groups of couples with male as well as combined infertility is performed. The groups were formed according the results of infertility treatment using methods of ART. The factors having had statistically significant impact on fertility were revealed

Small intestinal bacterial overgrowth syndrome and systemic inflammation in pathogenesis of hemodynamic changes at liver cirrhosis

Aim of investigation. To estimate the impact of small intestinal bacterial overgrowth (SIBO) to development of hemodynamic disorders at liver cirrhosis (LC). Material and methods. Original study included 50 LC patients and 15 generally healthy controls. Lactulose hydrogen breath test, serum level of C-reactive protein and cardiac ultrasound with simultaneous blood pressure (BP) and heart rate measurement, estimation of basic hemodynamic scores: mean blood pressure (MBP), cardiac output (CO), total peripheral vascular resistance (TPVR) were investigated in all patients. Results. LC patients with SIBO as compared to LC patients without SIBO had lower mean blood pressure (82.7±9.0 mm Hg vs 92.0±14.0 mm Hg) and TPVR (16.4±4.4 mm Hg × min/l vs 21.3±5.3 mm Hg • min/l), higher CO (5.38±1.41 l/min vs 4.52±1.03 l/ min) and serum C-rp (SIBO - 1.2÷10.5÷16.5 mg/l vs 0.6÷2.8÷9.1 mg/l). The presence of SIBO led to similar changes only at decompensated LC. At the same time no significant hemodynamic disorders were revealed at decompensated LC without SIBO and compensated LC irrespective of SIBO. At LC significant correlation of serum C-rp to TPVR (r=-0.367; p=0.009) and CO (r=0.313; p=0.027) was found, but not to mean BP (r=-0.227; p=0.113). Conclusion. SIBO at LC plays important role in vasodilation, arterial hypotension and hyperdynamic circulation. As these hemodynamic disorders aggravate the course of portal hypertension, the treatment of SIBO may reduce severity of the latter