Sky maps without anisotropies in the cosmic microwave background are a better fit to WMAP's uncalibrated time ordered data than the official sky maps

The purpose of this reanalysis of the WMAP uncalibrated time ordered data (TOD) was two fold. The first was to reassess the reliability of the detection of the anisotropies in the official WMAP sky maps of the cosmic microwave background (CMB). The second was to assess the performance of a proposed criterion in avoiding systematic error in detecting a signal of interest. The criterion was implemented by testing the null hypothesis that the uncalibrated TOD was consistent with no anisotropies when WMAP's hourly calibration parameters were allowed to vary. It was shown independently for all 20 WMAP channels that sky maps with no anisotropies were a better fit to the TOD than those from the official analysis. The recently launched Planck satellite should help sort out this perplexing result.Comment: 11 pages with 1 figure and 2 tables. Extensively rewritten to explain the research bette

Foregrounds in the BOOMERANG-LDB data: a preliminary rms analysis

We present a preliminary analysis of the BOOMERanG LDB maps, focused on foregrounds. BOOMERanG detects dust emission at moderately low galactic latitudes ($b > -20^o$) in bands centered at 90, 150, 240, 410 GHz. At higher Galactic latitudes, we use the BOOMERanG data to set conservative upper limits on the level of contamination at 90 and 150 GHz. We find that the mean square signal correlated with the IRAS/DIRBE dust template is less than 3% of the mean square signal due to CMB anisotropy

Neutrino masses and cosmic radiation density: Combined analysis

We determine the range of neutrino masses and cosmic radiation content allowed by the most recent CMB and large-scale structure data. In contrast to other recent works, we vary these parameters simultaneously and provide likelihood contours in the two-dimensional parameter space of N_eff}, the usual effective number of neutrino species measuring the radiation density, and \sum m_nu. The allowed range of \sum m_nu and N_eff has shrunk significantly compared to previous studies. The previous degeneracy between these parameters has disappeared, largely thanks to the baryon acoustic oscillation data. The likelihood contours differ significantly if \sum m_nu resides in a single species instead of the standard case of being equally distributed among all flavors. For \sum m_nu=0 we find 2.7 < N_eff < 4.6 at 95% CL while \sum m_nu < 0.62 eV at 95% CL for the standard radiation content.Comment: 8 pages, 2 figure

Neutrino mass from cosmology: Impact of high-accuracy measurement of the Hubble constant

Non-zero neutrino mass would affect the evolution of the Universe in observable ways, and a strong constraint on the mass can be achieved using combinations of cosmological data sets. We focus on the power spectrum of cosmic microwave background (CMB) anisotropies, the Hubble constant H_0, and the length scale for baryon acoustic oscillations (BAO) to investigate the constraint on the neutrino mass, m_nu. We analyze data from multiple existing CMB studies (WMAP5, ACBAR, CBI, BOOMERANG, and QUAD), recent measurement of H_0 (SHOES), with about two times lower uncertainty (5%) than previous estimates, and recent treatments of BAO from the Sloan Digital Sky Survey (SDSS). We obtained an upper limit of m_nu < 0.2eV (95% C.L.), for a flat LambdaCDM model. This is a 40% reduction in the limit derived from previous H_0 estimates and one-third lower than can be achieved with extant CMB and BAO data. We also analyze the impact of smaller uncertainty on measurements of H_0 as may be anticipated in the near term, in combination with CMB data from the Planck mission, and BAO data from the SDSS/BOSS program. We demonstrate the possibility of a 5 sigma detection for a fiducial neutrino mass of 0.1eV or a 95% upper limit of 0.04eV for a fiducial of m_nu = 0eV. These constraints are about 50% better than those achieved without external constraint. We further investigate the impact on modeling where the dark-energy equation of state is constant but not necessarily -1, or where a non-flat universe is allowed. In these cases, the next-generation accuracies of Planck, BOSS, and 1% measurement of H_0 would all be required to obtain the limit m_nu < 0.05 - 0.06eV (95% C.L.) for the fiducial of m_nu = 0eV. The independence of systematics argues for pursuit of both BAO and H_0 measurements.Comment: 22 pages, 6 figures, 12 table

The Quintessential CMB, Past & Future

The past, present and future of cosmic microwave background (CMB) anisotropy research is discussed, with emphasis on the Boomerang and Maxima balloon experiments. These data are combined with large scale structure (LSS) information and high redshift supernova (SN1) observations to explore the inflation-based cosmic structure formation paradigm. Here we primarily focus on a simplified inflation parameter set, {omega_b,omega_{cdm},Omega_{tot}, Omega_Q,w_Q, n_s,tau_C, sigma_8}. After marginalizing over the other cosmic and experimental variables, we find the current CMB+LSS+SN1 data gives Omega_{tot}=1.04\pm 0.05, consistent with (non-baroque) inflation theory. Restricting to Omega_{tot}=1, we find a nearly scale invariant spectrum, n_s =1.03 \pm 0.07. The CDM density, omega_{cdm}=0.17\pm 0.02, is in the expected range, but the baryon density, omega_b=0.030\pm 0.004, is slightly larger than the current nucleosynthesis estimate. Substantial dark energy is inferred, Omega_Q\approx 0.68\pm 0.05, and CMB+LSS Omega_Q values are compatible with the independent SN1 estimates. The dark energy equation of state, parameterized by a quintessence-field pressure-to-density ratio w_Q, is not well determined by CMB+LSS (w_Q<-0.3 at 95%CL), but when combined with SN1 the resulting w_Q<-0.7 limit is quite consistent with the w_Q=-1 cosmological constant case. Though forecasts of statistical errors on parameters for current and future experiments are rosy, rooting out systematic errors will define the true progress.Comment: 14 pages, 3 figs., in Proc. CAPP-2000 (AIP), CITA-2000-6

CMB Analysis of Boomerang & Maxima & the Cosmic Parameters {Omega_tot,Omega_b h^2,Omega_cdm h^2,Omega_Lambda,n_s}

We show how estimates of parameters characterizing inflation-based theories of structure formation localized over the past year when large scale structure (LSS) information from galaxy and cluster surveys was combined with the rapidly developing cosmic microwave background (CMB) data, especially from the recent Boomerang and Maxima balloon experiments. All current CMB data plus a relatively weak prior probability on the Hubble constant, age and LSS points to little mean curvature (Omega_{tot} = 1.08\pm 0.06) and nearly scale invariant initial fluctuations (n_s =1.03\pm 0.08), both predictions of (non-baroque) inflation theory. We emphasize the role that degeneracy among parameters in the L_{pk} = 212\pm 7 position of the (first acoustic) peak plays in defining the $\Omega_{tot}$ range upon marginalization over other variables. Though the CDM density is in the expected range (\Omega_{cdm}h^2=0.17\pm 0.02), the baryon density Omega_bh^2=0.030\pm 0.005 is somewhat above the independent 0.019\pm 0.002 nucleosynthesis estimate. CMB+LSS gives independent evidence for dark energy (Omega_\Lambda=0.66\pm 0.06) at the same level as from supernova (SN1) observations, with a phenomenological quintessence equation of state limited by SN1+CMB+LSS to w_Q<-0.7 cf. the w_Q=-1 cosmological constant case.Comment: 11 pages, 3 figs., in Proc. IAU Symposium 201 (PASP), CITA-2000-6

Probing the primordial power spectra with inflationary priors

We investigate constraints on power spectra of the primordial curvature and tensor perturbations with priors based on single-field slow-roll inflation models. We stochastically draw the Hubble slow-roll parameters and generate the primordial power spectra using the inflationary flow equations. Using data from recent observations of CMB and several measurements of geometrical distances in the late Universe, Bayesian parameter estimation and model selection are performed for models that have separate priors on the slow-roll parameters. The same analysis is also performed adopting the standard parameterization of the primordial power spectra. We confirmed that the scale-invariant Harrison-Zel'dovich spectrum is disfavored with increased significance from previous studies. While current observations appear to be optimally modeled with some simple models of single-field slow-roll inflation, data is not enough constraining to distinguish these models.Comment: 23 pages, 3 figures, 7 tables, accepted for publication in JCA

First Estimations of Cosmological Parameters From BOOMERANG

The anisotropy of the cosmic microwave background radiation contains information about the contents and history of the universe. We report new limits on cosmological parameters derived from the angular power spectrum measured in the first Antarctic flight of the BOOMERANG experiment. Within the framework of inflation-motivated adiabatic cold dark matter models, and using only weakly restrictive prior probabilites on the age of the universe and the Hubble expansion parameter $h$, we find that the curvature is consistent with flat and that the primordial fluctuation spectrum is consistent with scale invariant, in agreement with the basic inflation paradigm. We find that the data prefer a baryon density $\Omega_b h^2$ above, though similar to, the estimates from light element abundances and big bang nucleosynthesis. When combined with large scale structure observations, the BOOMERANG data provide clear detections of both dark matter and dark energy contributions to the total energy density $\Omega_{\rm {tot}}$, independent of data from high redshift supernovae.Comment: As submitted to PRD, revised longer version with an additional figur

Early Dark Energy Cosmologies

We propose a novel parameterization of the dark energy density. It is particularly well suited to describe a non-negligible contribution of dark energy at early times and contains only three parameters, which are all physically meaningful: the fractional dark energy density today, the equation of state today and the fractional dark energy density at early times. As we parameterize Omega_d(a) directly instead of the equation of state, we can give analytic expressions for the Hubble parameter, the conformal horizon today and at last scattering, the sound horizon at last scattering, the acoustic scale as well as the luminosity distance. For an equation of state today w_0 < -1, our model crosses the cosmological constant boundary. We perform numerical studies to constrain the parameters of our model by using Cosmic Microwave Background, Large Scale Structure and Supernovae Ia data. At 95% confidence, we find that the fractional dark energy density at early times Omega_early < 0.06. This bound tightens considerably to Omega_early < 0.04 when the latest Boomerang data is included. We find that both the gold sample of Riess et. al. and the SNLS data by Astier et. al. when combined with CMB and LSS data mildly prefer w_0 < -1, but are well compatible with a cosmological constant.Comment: 6 pages, 3 figures; references added, matches published versio

Clinical relevance assessment of animal preclinical research (RAA) tool: development and explanation

Background Only a small proportion of preclinical research (research performed in animal models prior to clinical trials in humans) translates into clinical benefit in humans. Possible reasons for the lack of translation of the results observed in preclinical research into human clinical benefit include the design, conduct, and reporting of preclinical studies. There is currently no formal domain-based assessment of the clinical relevance of preclinical research. To address this issue, we have developed a tool for the assessment of the clinical relevance of preclinical studies, with the intention of assessing the likelihood that therapeutic preclinical findings can be translated into improvement in the management of human diseases. / Methods We searched the EQUATOR network for guidelines that describe the design, conduct, and reporting of preclinical research. We searched the references of these guidelines to identify further relevant publications and developed a set of domains and signalling questions. We then conducted a modified Delphi-consensus to refine and develop the tool. The Delphi panel members included specialists in evidence-based (preclinical) medicine specialists, methodologists, preclinical animal researchers, a veterinarian, and clinical researchers. A total of 20 Delphi-panel members completed the first round and 17 members from five countries completed all three rounds. / Results This tool has eight domains (construct validity, external validity, risk of bias, experimental design and data analysis plan, reproducibility and replicability of methods and results in the same model, research integrity, and research transparency) and a total of 28 signalling questions and provides a framework for researchers, journal editors, grant funders, and regulatory authorities to assess the potential clinical relevance of preclinical animal research. / Conclusion We have developed a tool to assess the clinical relevance of preclinical studies. This tool is currently being piloted