206 research outputs found
Reaching the hydrodynamic regime in a Bose-Einstein condensate by suppression of avalanche
We report the realization of a Bose-Einstein condensate (BEC) in the
hydrodynamic regime. The hydrodynamic regime is reached by evaporative cooling
at a relative low density suppressing the effect of avalanches. With the
suppression of avalanches a BEC containing 120.10^6 atoms is produced. The
collisional opacity can be tuned from the collisionless regime to a collisional
opacity of more than 3 by compressing the trap after condensation. In the
collisional opaque regime a significant heating of the cloud at time scales
shorter than half of the radial trap period is measured. This is direct proof
that the BEC is hydrodynamic.Comment: Article submitted for Phys. Rev. Letters, 6 figure
Large atom number Bose-Einstein condensate of sodium
We describe the setup to create a large Bose-Einstein condensate containing
more than 120x10^6 atoms. In the experiment a thermal beam is slowed by a
Zeeman slower and captured in a dark-spot magneto-optical trap (MOT). A typical
dark-spot MOT in our experiments contains 2.0x10^10 atoms with a temperature of
320 microK and a density of about 1.0x10^11 atoms/cm^3. The sample is spin
polarized in a high magnetic field, before the atoms are loaded in the magnetic
trap. Spin polarizing in a high magnetic field results in an increase in the
transfer efficiency by a factor of 2 compared to experiments without spin
polarizing. In the magnetic trap the cloud is cooled to degeneracy in 50 s by
evaporative cooling. To suppress the 3-body losses at the end of the
evaporation the magnetic trap is decompressed in the axial direction.Comment: 11 pages, 12 figures, submitted to Review Of Scientific Instrument
Excitations of Bose-Einstein condensates in a one-dimensional periodic potential
We report on the experimental investigation of the response of a
three-dimensional Bose-Einstein condensate (BEC) in the presence of a
one-dimensional (1D) optical lattice. By means of Bragg spectroscopy we probe
the band structure of the excitation spectrum in the presence of the periodic
potential. We selectively induce elementary excitations of the BEC choosing the
transferred momentum and we observe different resonances in the energy
transfer, corresponding to the transitions to different bands. The frequency,
the width and the strength of these resonances are investigated as a function
of the amplitude of the 1D optical lattice.Comment: 5 pages, 4 figure
Noise correlation spectroscopy of the broken order of a Mott insulating phase
We use a two-color lattice to break the homogeneous site occupation of an
atomic Mott Insulator of bosonic 87Rb. We detect the disruption of the ordered
Mott domains via noise correlation analysis of the atomic density distribution
after time-of-flight. The appearance of additional correlation peaks evidences
the redistribution of the atoms into a strongly inhomogeneous insulating state,
in quantitative agreement with the predictions
Brachytherapy quality assurance in the PORTEC-4a trial for high-intermediate risk endometrial cancer
Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening
Aims More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). Although its pathophysiology remains incompletely understood, it has been proposed that these comorbidities induce systemic inflammation, coronary microvascular dysfunction, and oxidative stress, leading to myocardial fibrosis, myocyte stiffening and, ultimately, diastolic dysfunction. Here, we tested this hypothesis in a swine model chronically exposed to three common comorbidities. Methods and results DM (induced by streptozotocin), HC (produced by high fat diet), and HT (resulting from renal artery embolization), were produced in 10 female swine, which were followed for 6 months. Eight female healthy swine on normal pig-chow served as controls. The DM + HC + HT group showed hyperglycemia, HC, hypertriglyceridemia, renal dysfunction and HT, which were associated with systemic inflammation. Myocardial superoxide production was markedly increased, due to increased NOX activity and eNOS uncoupling, and associated with reduced NO production, and impaired coronary small artery endothelium-dependent vasodilation. These abnormalities were accompanied by increased myocardial collagen content, reduced capillary/fiber ratio, and elevated passive cardiomyocyte stiffness, resulting in an increased left ventricular end-diastolic stiffness (measured by pressure-volume catheter) and a trend towards a reduced E/A ratio (measured by cardiac MRI), while ejection fraction was maintained. Conclusions The combination of three common comorbidities leads to systemic inflammation, myocardial oxidative stress, and coronary microvascular dysfunction, which associate with myocardial stiffening and LV diastolic dysfunction with preserved ejection fraction
Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening
Aims More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). Although its pathophysiology remains incompletely understood, it has been proposed that these comorbidities induce systemic inflammation, coronary microvascular dysfunction, and oxidative stress, leading to myocardial fibrosis, myocyte stiffening and, ultimately, diastolic dysfunction. Here, we tested this hypothesis in a swine model chronically exposed to three common comorbidities.Methods and results DM (induced by streptozotocin), HC (produced by high fat diet), and HT (resulting from renal artery embolization), were produced in 10 female swine, which were followed for 6 months. Eight female healthy swine on normal pig-chow served as controls. The DM+HC+HT group showed hyperglycemia, HC, hypertriglyceridemia, renal dysfunction and HT, which were associated with systemic inflammation. Myocardial superoxide production was markedly increased, due to increased NOX activity and eNOS uncoupling, and associated with reduced NO production, and impaired coronary small artery endothelium-dependent vasodilation. These abnormalities were accompanied by increased myocardial collagen content, reduced capillary/fiber ratio, and elevated passive cardiomyocyte stiffness, resulting in an increased left ventricular end-diastolic stiffness (measured by pressure-volume catheter) and a trend towards a reduced E/A ratio (measured by cardiac MRI), while ejection fraction was maintained.Conclusions The combination of three common comorbidities leads to systemic inflammation, myocardial oxidative stress, and coronary microvascular dysfunction, which associate with myocardial stiffening and LV diastolic dysfunction with preserved ejection fraction
Health-related physical fitness of adolescents and young adults with myelomeningocele
To assess components of health-related physical fitness in adolescents and young adults with myelomeningocele (MMC), and to study relations between aerobic capacity and other health-related physical fitness components. This cross-sectional study included 50 adolescents and young adults with MMC, aged 16–30 years (25 males). Aerobic capacity was quantified by measuring peak oxygen uptake (peakVO2) during a maximal exercise test on a cycle or arm ergometer depending on the main mode of ambulation. Muscle strength of upper and lower extremity muscles was assessed using a hand-held dynamometer. Regarding flexibility, we assessed mobility of hip, knee and ankle joints. Body composition was assessed by measuring thickness of four skin-folds. Relations were studied using linear regression analyses. Average peakVO2 was 1.48 ± 0.52 l/min, 61% of the participants had subnormal muscle strength, 61% had mobility restrictions in at least one joint and average sum of four skin-folds was 74.8 ± 38.8 mm. PeakVO2 was significantly related to gender, ambulatory status and muscle strength, explaining 55% of its variance. Adolescents and young adults with MMC have poor health-related physical fitness. Gender and ambulatory status are important determinants of peakVO2. In addition, we found a small, but significant relationship between peakVO2 and muscle strength
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