290 research outputs found
Empathy among the members of isolated culture
This article presents a look at the resocialization, as a cultural offer, which were presented for imprisoned persons. Perceiving the phenomenon of the prison subculture, as a threat to the future readaptation, a program with using elements of drama was suggested and presented whether and what scope he can contribute to the increase in the level of empathy in
Why place matters in residential care: the mediating role of place attachment in the relation between adolescents’ rights and psychological well-being
Little evidence exists on the relationship between rights’ perceptions and well-being outcomes during the adolescence, and particularly in care, as well as on the mediating role of place attachment. Young people in residential care are psychologically and socially vulnerable, showing greater difficulties than their peers do in the family. Youth’s rights fulfilment in residential care may positively affect their psychological functioning together with positive attachments to this place. A sample of 365 adolescents in residential care settings (M = 14.71, SD = 1.81) completed a set of self-reported measures, specifically, the Rights perceptions scale, the Place attachment scale and Scales of psychological well-being. Results revealed significant mediating effects of place attachment (Global scale and subscales of Friends Bonding and Place Dependence) on the relationship between Participation and Protection rights in residential care and Psychological well-being (Positive Relations with others, Personal Growth and Self-Acceptance). The positive role of rights fulfilment in residential care, specifically participation opportunities, as well as the role of youth’s attachment to the care setting are discussed based on previous evidence and theoretical assumptions. A set of practical implications is described.info:eu-repo/semantics/acceptedVersio
Existence and stability of viscoelastic shock profiles
We investigate existence and stability of viscoelastic shock profiles for a
class of planar models including the incompressible shear case studied by
Antman and Malek-Madani. We establish that the resulting equations fall into
the class of symmetrizable hyperbolic--parabolic systems, hence spectral
stability implies linearized and nonlinear stability with sharp rates of decay.
The new contributions are treatment of the compressible case, formulation of a
rigorous nonlinear stability theory, including verification of stability of
small-amplitude Lax shocks, and the systematic incorporation in our
investigations of numerical Evans function computations determining stability
of large-amplitude and or nonclassical type shock profiles.Comment: 43 pages, 12 figure
Prediction studies of environment-friendly biodegradable polymeric packaging based on PLA. Influence of specimens’ thickness on the hydrolytic degradation profile
Application of new biodegradable polymer packaging based on polylactide (PLA), susceptible to organic recycling, can help in the waste reduction in landfills. In this paper, the results of the study on abiotic degradation of PLA and its blend containing 15 mol% of poly[(R,S)-3-hydroxybutyrate], as a model for the first step of organic recycling were presented. The samples used for this study have different shapes and thicknesses: rigid films and cuboid-bars. Particular emphasis was placed on determining the pattern of degradation products released into the medium. Originally, the results of present study revealed that the application of electrospray ionization mass spectrometry supported by high performance liquid chromatography allowed envisaging the differences in the degradation products pattern released from the studied PLA-based samples differing in thickness. The significant differences in degradation products pattern were predominately observed in the first steps of incubation process and are caused by an autocatalytic effect, which occurs mainly during degradation of the large size PLA samples. Although, the thickness of PLA-based packaging changes the degradation product patterns, however this does not increase the total amounts of acids released to the medium. Thus, it may be concluded that thickness should not affect significantly organic recycling of the packaging
Chasing Graphene-Based Anticancer Drugs: Where are We Now on the Biomedical Graphene Roadmap?
Katarzyna Uzdrowska,1 Narcyz Knap,1 Jacek Gulczynski,2 Alicja Kuban-Jankowska,1 Wiktoria Struck-Lewicka,3 Michal J Markuszewski,3 Tomasz Bączek,3 Ewa Izycka-Swieszewska,2 Magdalena Gorska-Ponikowska1 1Department of Medical Chemistry, Medical University of Gdansk, Gdansk, 80-211, Poland; 2Faculty of Health Sciences with the Institute of Maritime and Tropical Medicine, Medical University of Gdansk, Gdansk, 80-211, Poland; 3Faculty of Pharmacy, Medical University of Gdansk, Gdansk, 80-416, PolandCorrespondence: Magdalena Gorska-Ponikowska, Department of Medical Chemistry, Medical University of Gdansk, 1 Debinki St, Gdansk, 80-211, Poland, Tel +48 58 349 14 50, Fax +48 58 349 14 56, Email [email protected]: Graphene and graphene-based materials have attracted growing interest for potential applications in medicine because of their good biocompatibility, cargo capability and possible surface functionalizations. In parallel, prototypic graphene-based devices have been developed to diagnose, imaging and track tumor growth in cancer patients. There is a growing number of reports on the use of graphene and its functionalized derivatives in the design of innovative drugs delivery systems, photothermal and photodynamic cancer therapy, and as a platform to combine multiple therapies. The aim of this review is to introduce the latest scientific achievements in the field of innovative composite graphene materials as potentially applied in cancer therapy. The “Technology and Innovation Roadmap” published in the Graphene Flagship indicates, that the first anti-cancer drugs using graphene and graphene-derived materials will have appeared on the market by 2030. However, it is necessary to broaden understanding of graphene-based material interactions with cellular metabolism and signaling at the functional level, as well as toxicity. The main aspects of further research should elucidate how treatment methods (e.g., photothermal therapy, photodynamic therapy, combination therapy) and the physicochemical properties of graphene materials influence their ability to modulate autophagy and kill cancer cells. Interestingly, recent scientific reports also prove that graphene nanocomposites modulate cancer cell death by inducing precise autophagy dysfunctions caused by lysosome damage. It turns out as well that developing photothermal oncological treatments, it should be taken into account that near-infrared-II radiation (1000– 1500 nm) is a better option than NIR-I (750– 1000 nm) because it can penetrate deeper into tissues due to less scattering at longer wavelengths radiation.Keywords: graphene-based materials, oncological therapies, cancer treatment, biomedical innovations, drugs delivery system
Discovery of mating in the major African livestock pathogen Trypanosoma congolense
The protozoan parasite, Trypanosoma congolense, is one of the most economically important pathogens of livestock in Africa and, through its impact on cattle health and productivity, has a significant effect on human health and well being. Despite the importance of this parasite our knowledge of some of the fundamental biological processes is limited. For example, it is unknown whether mating takes place. In this paper we have taken a population genetics based approach to address this question. The availability of genome sequence of the parasite allowed us to identify polymorphic microsatellite markers, which were used to genotype T. congolense isolates from livestock in a discrete geographical area of The Gambia. The data showed a high level of diversity with a large number of distinct genotypes, but a deficit in heterozygotes. Further analysis identified cryptic genetic subdivision into four sub-populations. In one of these, parasite genotypic diversity could only be explained by the occurrence of frequent mating in T. congolense. These data are completely inconsistent with previous suggestions that the parasite expands asexually in the absence of mating. The discovery of mating in this species of trypanosome has significant consequences for the spread of critical traits, such as drug resistance, as well as for fundamental aspects of the biology and epidemiology of this neglected but economically important pathogen
Micrometeorological methods for greenhouse gas measurement
Micrometeorological techniques are useful if greenhouse gas (GHG) emissions from larger areas (i.e. entire fields) should be integrated. The theory and the various techniques such as flux-gradient, aerodynamic, and Bowen ratio as well as Eddy correlationmethods are described and discussed. Alternativemethods also used areEddy correlation, mass balance techniques, and tracer-based methods.The analytical techniques with current state-of-the-art approaches as well as the calculation procedures are presented
Greenhouse gases from agriculture
The rapidly changing global climate due to increased emission of anthropogenic greenhouse gases (GHGs) is leading to an increased occurrence of extreme weather events such as droughts, floods, and heatwaves. The three major GHGs are carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O). The major natural sources of CO2 include ocean-atmosphere exchange, respiration of animals, soils (microbial respiration) and plants, and volcanic eruption; while the anthropogenic sources include burning of fossil fuel (coal, natural gas, and oil), deforestation, and the cultivation of land that increases the decomposition of soil organic matter and crop and animal residues. Natural sources of CH4 emission include wetlands, termite activities, and oceans. Paddy fields used for rice production, livestock production systems (enteric emission from ruminants), landfills, and the production and use of fossil fuels are the main anthropogenic sources of CH4. Nitrous oxide, in addition to being a major GHG, is also an ozone-depleting gas. N2O is emitted by natural processes from oceans and terrestrial ecosystems. Anthropogenic N2O emissions occur mostly through agricultural and other land-use activities and are associated with the intensification of agricultural and other human activities such as increased use of synthetic fertiliser (119.4 million tonnes of N worldwide in 2019), inefficient use of irrigation water, deposition of animal excreta (urine and dung) from grazing animals, excessive and inefficient application of farm effluents and animal manure to croplands and pastures, and management practices that enhance soil organic N mineralisation and C decomposition. Agriculture could act as a source and a sink of GHGs. Besides direct sources, GHGs also come from various indirect sources, including upstream and downstream emissions in agricultural systems and ammonia (NH3) deposition from fertiliser and animal manure
Shape programming for narrow ribbons of nematic elastomers
Using the theory of Γ-convergence, we derive from three-dimensional elasticity new one-dimensional models for non-Euclidean elastic ribbons, i.e., ribbons exhibiting spontaneous curvature and twist. We apply the models to shape-selection problems for thin films of nematic elastomers with twist and splay-bend texture of the nematic director. For the former, we discuss the possibility of helicoid-like shapes as an alternative to spiral ribbons
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