227 research outputs found
Servitising manufacturers:the impact of service complexity and contractual and relational capabilities
Processes of servitisation will lead providers to change their service delivery structures, but they also need to transform broader organisational attributes including contractual and relational capabilities. Based on case studies in the European healthcare sector, we investigate the influence of increasing levels of service complexity on this transformation. Our findings are potentially counter-intuitive, suggesting that contractual capabilities do not increase with service complexity. Instead, we observed increased levels of relational capabilities, manifest in the visibility of the provider on the customer site, the number of ânon-requestedâ site visits and increasingly informal information exchange.</p
Prescribed Fire Alters Structure and Composition of a Mid-Atlantic Oak Forest up to Eight Years After Burning
Background
Prescribed fire in Eastern deciduous forests has been understudied relative to other regions in the United States. In Pennsylvania, USA, prescribed fire use has increased more than five-fold since 2009, yet forest response has not been extensively studied. Due to variations in forest composition and the feedback between vegetation and fire, Pennsylvania deciduous forests may burn and respond differently than forests across the eastern US. We measured changes in forest structure and composition up to eight years after prescribed fire in a hardwood forest of the Ridge and Valley region of the Appalachian Mountains in central Pennsylvania. Results
Within five years post fire, tree seedling density increased more than 72% while sapling density decreased by 90%, midstory density decreased by 46%, and overstory response varied. Following one burn in the mixed-oak unit, overstory tree density decreased by 12%. In the aspenâoak unit, where pre-fire harvesting and two burns occurred, overstory tree density increased by 25%. Not all tree species responded similarly and post-fire shifts in species relative abundance occurred in sapling and seedling size classes. Abundance of red maple and cherry species decreased, whereas abundance of sassafras, quaking aspen, black oak, and hickory species increased. Conclusions
Forest composition plays a key role in the vegetationâfire relationship and localized studies are necessary to measure forest response to prescribed fire. Compositional shifts in tree species were most pronounced in the aspenâoak unit where pre-fire overstory thinning and two prescribed fires were applied and significant structural changes occurred in all stands after just one burn. Increases in fire-tolerant tree species combined with reductions in fire-intolerant species highlight the role of prescribed fire in meeting management objectives such as altering forest structure and composition to improve game habitat in mid-Atlantic hardwood forests
Servitising manufacturers:the impact of service complexity and contractual and relational capabilities
Processes of servitisation will lead providers to change their service delivery structures, but they also need to transform broader organisational attributes including contractual and relational capabilities. Based on case studies in the European healthcare sector, we investigate the influence of increasing levels of service complexity on this transformation. Our findings are potentially counter-intuitive, suggesting that contractual capabilities do not increase with service complexity. Instead, we observed increased levels of relational capabilities, manifest in the visibility of the provider on the customer site, the number of ânon-requestedâ site visits and increasingly informal information exchange.</p
Prescribed fire: Understanding liability, laws and risk
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Human gestational Nâmethylâdâaspartate receptor autoantibodies impair neonatal murine brain function
Objective: Maternal autoantibodies are a risk factor for impaired brain development in offspring. Antibodies (ABs) against the NR1 (GluN1) subunit of the N-methyl-d-aspartate receptor (NMDAR) are among the most frequently diagnosed anti-neuronal surface ABs, yet little is known about effects on fetal development during pregnancy.
Methods: We established a murine model of in utero exposure to human recombinant NR1 and isotype-matched nonreactive control ABs. Pregnant C57BL/6J mice were intraperitoneally injected on embryonic days 13 and 17 each with 240ÎŒg of human monoclonal ABs. Offspring were investigated for acute and chronic effects on NMDAR function, brain development, and behavior.
Results: Transferred NR1 ABs enriched in the fetus and bound to synaptic structures in the fetal brain. Density of NMDAR was considerably reduced (up to -49.2%) and electrophysiological properties were altered, reflected by decreased amplitudes of spontaneous excitatory postsynaptic currents in young neonates (-34.4%). NR1 AB-treated animals displayed increased early postnatal mortality (+27.2%), impaired neurodevelopmental reflexes, altered blood pH, and reduced bodyweight. During adolescence and adulthood, animals showed hyperactivity (+27.8% median activity over 14 days), lower anxiety, and impaired sensorimotor gating. NR1 ABs caused long-lasting neuropathological effects also in aged mice (10 months), such as reduced volumes of cerebellum, midbrain, and brainstem.
Interpretation: The data collectively support a model in which asymptomatic mothers can harbor low-level pathogenic human NR1 ABs that are diaplacentally transferred, causing neurotoxic effects on neonatal development. Thus, AB-mediated network changes may represent a potentially treatable neurodevelopmental congenital brain disorder contributing to lifelong neuropsychiatric morbidity in affected children
KlimafolgenabschĂ€tzungen in der Wasserwirtschaft und deren Nutzen fĂŒr die Praxis
KlimafolgenClimate ImpactsDer globale Klimawandel kann regional unterschiedliche Auswirkungen haben. WĂ€hrend sich die wissenschaftliche Forschung vor allem mit der Analyse der Daten beschĂ€ftigt, ist die fachliche Praxis darum bemĂŒht, die Ergebnisse zu interpretieren und Handlungsempfehlungen daraus abzuleiten. Im Zuge des Projektes KliBiW (Globaler Klimawandel â Wasserwirtschaftliche FolgenabschĂ€tzung fĂŒr das Binnenland) wurden die Auswirkungen des Klimawandels auf die Hochwasser- und NiedrigwasserverhĂ€ltnisse in Niedersachsen untersucht. Hierzu wurden die Daten von zwei regionalen Klimamodellen (WETTREG2006 und REMO), beide angetrieben durch das Globalmodell ECHAM5/MPI-OM, rĂ€umlich interpoliert und die NiederschlĂ€ge zum Teil zeitlich disaggregiert, um hoch aufgelöste Klimainformationen bereitzuhalten. AnschlieĂend erfolgte die Kopplung mit einem hydrologischen Modellsystem (PANTA RHEI), das bereits in der Hochwasservorhersagezentrale des NLWKN im Einsatz ist. Ăber Langzeitsimulationen wurden zukĂŒnftige VerĂ€nderungen in den AbflussverhĂ€ltnissen rĂ€umlich und zeitlich differenziert fĂŒr das Aller-Leine Gebiet identifiziert. Als BetrachtungszeitrĂ€ume dienten eine nahe Zukunftsphase (2021 â 2050) und eine ferne Zukunftsphase (2071 â 2100). Die VerĂ€nderungen verschiedener hydrologischer Hoch- und Niedrigwasser-KenngröĂen wurden gegenĂŒber einem Kontrollzeitraum (1971 â 2000) aufgezeigt. Die Auswertungen an 8 Pegeln in Einzugsgebieten >1.000 kmÂČ auf Tageswertbasis und an 6 Pegeln in Einzugsgebieten <1.000 kmÂČ auf Stundenwertbasis zeigten, dass sich die Hochwassersituation zukĂŒnftig verschĂ€rfen kann. WĂ€hrend kleinere HochwĂ€sser hĂ€ufiger auftreten können, nehmen die ScheitelabflĂŒsse insbesondere in der fernen Zukunft zu. Aussagen zu gröĂeren Ereignissen sind aufgrund der groĂen Bandbreite der Ergebnisse jedoch mit erheblichen Unsicherheiten behaftet. Die NiedrigwasserverhĂ€ltnisse zeigten eine Abnahme der AbflĂŒsse, speziell im Sommer, sowie eine Zunahme der Dauer undnder Volumendefizite bei Trockenperioden. Hierbei erschien die VariabilitĂ€t und AusprĂ€gung der Trockenheit in kleineren Einzugsgebieten etwas gröĂer. Die Nutzung dieser Erkenntnisse stellt die fachliche Praxis vor die Herausforderung, die Ergebnisse zu interpretieren und zu kommunizieren. Unsicherheiten in den Modellketten mĂŒssen berĂŒcksichtigt und, wenn möglich, quantifiziert werden. Die abgeleiteten hydrologischen Konsequenzen des Klimawandels können z.B. Anwendung finden in der gesetzlich geforderten BerĂŒcksichtigung der Auswirkungen des Klimawandels auf die Risikogebiete entsprechend der Hochwasserrisikomanagement-Richtlinie (2007/60/EG). Dieser Beitrag gibt einen Ăberblick ĂŒber wasserwirtschaftlich relevante Auswertungen von Klimamodelldaten auf unterschiedlichen rĂ€umlichen Skalen und zeigt anhand ausgewĂ€hlter Beispiele auf, wie primĂ€r im wissenschaftlichen Kontext erhobene Ergebnisse effektiv fĂŒr praxisrelevante Fragestellungen genutzt werden können
Looking back and moving forward: 50 years of soil and soil fertility management research in sub-Saharan Africa
Article purchased; Published online: 02 Nov 2017Low and declining soil fertility has been recognized for a long time as a major impediment to intensifying agriculture in sub-Saharan Africa (SSA). Consequently, from the inception of international agricultural research, centres operating in SSA have had a research programme focusing on soil and soil fertility management, including the International Institute of Tropical Agriculture (IITA). The scope, content, and approaches of soil and soil fertility management research have changed over the past decades in response to lessons learnt and internal and external drivers and this paper uses IITA as a case study to document and analyse
the consequences of strategic decisions taken on technology development, validation, and ultimately uptake by smallholder farmers in SSA. After an initial section describing the external environment within which soil and soil fertility management research is operating, various dimensions of this research area are covered: (i) âstrategic researchâ, âResearch for Developmentâ, partnerships, and balancing acts, (ii) changing role of characterization due to the expansion in geographical scope and shift from soils to farms and livelihoods, (iii) technology development: changes in vision, content, and scale of intervention, (iv) technology validation and delivery to farming communities, and (v) impact and feedback to the technology development and validation process. Each of the above sections follows a chronological approach, covering the last five decades (from the late 1960s till today). The paper ends with a number of lessons learnt which could be considered for future initiatives aiming at developing and
delivering improved soil and soil fertility management practices to smallholder farming communities in SSA
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